Although several considerations have been raised suggesting a beneficial effect of N-acetyl cysteine(NAC)for the treatment of severe acute respiratory syndrome coronavirus 2 infection,there is currently no clinical ev...Although several considerations have been raised suggesting a beneficial effect of N-acetyl cysteine(NAC)for the treatment of severe acute respiratory syndrome coronavirus 2 infection,there is currently no clinical evidence that NAC truly prevents coronavirus disease 2019(COVID-19),reduces the severity of the disease,or improves the outcome.Appropriately designed clinical trials are warranted to prove or disprove a therapeutic effect of NAC for COVID-19 patients.展开更多
We read with interest the case report by Ban et al. about a 17-year-old male with myoclonic epilepsy with ragged red fibers （MERRF） syndrome being attributed to the mitochondrial tRNA glutamic acid （tRNA [Glu]） va...We read with interest the case report by Ban et al. about a 17-year-old male with myoclonic epilepsy with ragged red fibers （MERRF） syndrome being attributed to the mitochondrial tRNA glutamic acid （tRNA [Glu]） variant mitochondrial 14709T〉C. The authors claimed that the variant occurred sporadically and has not been reported in association with a MERRF phenotype so far. We have the following comments and concerns.展开更多
文摘Although several considerations have been raised suggesting a beneficial effect of N-acetyl cysteine(NAC)for the treatment of severe acute respiratory syndrome coronavirus 2 infection,there is currently no clinical evidence that NAC truly prevents coronavirus disease 2019(COVID-19),reduces the severity of the disease,or improves the outcome.Appropriately designed clinical trials are warranted to prove or disprove a therapeutic effect of NAC for COVID-19 patients.
文摘We read with interest the case report by Ban et al. about a 17-year-old male with myoclonic epilepsy with ragged red fibers （MERRF） syndrome being attributed to the mitochondrial tRNA glutamic acid （tRNA [Glu]） variant mitochondrial 14709T〉C. The authors claimed that the variant occurred sporadically and has not been reported in association with a MERRF phenotype so far. We have the following comments and concerns.
