Inflammation is a common feature of aging tissues,being involved in most,if not all,age-related diseases.The origin of a low-grade inflammation state in aging(inflammaging)is multifactorial and may involve changes in ...Inflammation is a common feature of aging tissues,being involved in most,if not all,age-related diseases.The origin of a low-grade inflammation state in aging(inflammaging)is multifactorial and may involve changes in body composition,immunosenescence,autophagy,microbiota modification and loss of proteostasis.The heat shock response pathway(HSR,and HSP70 expression)plays an important role as a mechanism of resolution of inflammation and proteostasis control.In this review,we sought to discuss the mechanisms that may lead to inflammaging,and the importance of the HSP70 in this process.Besides,we also discuss how physical exercise,particularly resistance training,can improve the HSR and the inflammatory balance of elderly people.展开更多
基金supported by FAPERGS and CNPq.Mauricio Krause received grant support from FAPERGS(Edital FAPERGS/Decit/SCTIE/MS/CNPq/SESRS n.03/2017-PPSUS#17/2551-0001424-3).
文摘Inflammation is a common feature of aging tissues,being involved in most,if not all,age-related diseases.The origin of a low-grade inflammation state in aging(inflammaging)is multifactorial and may involve changes in body composition,immunosenescence,autophagy,microbiota modification and loss of proteostasis.The heat shock response pathway(HSR,and HSP70 expression)plays an important role as a mechanism of resolution of inflammation and proteostasis control.In this review,we sought to discuss the mechanisms that may lead to inflammaging,and the importance of the HSP70 in this process.Besides,we also discuss how physical exercise,particularly resistance training,can improve the HSR and the inflammatory balance of elderly people.
