-765G > C COX-2 polymorphism may be a susceptibility marker for gastric adenocarcinoma in patients with atrophy or intestinal metaplasia

AIM: To investigate the relationship between the -765G > C COX-2 polymorphism and the development of different gastric lesions: atrophy or intestinal metaplasia and gastric adenocarcinoma. METHODS: A cross-sectional study was performed involving 320 Portuguese individuals (210 without evidence of neoplastic disease, 73 patients with gastric adenocarcinomas and 37 with atrophy or intestinal metaplasia) using a PCR-RFLP method. RESULTS: -765C allele was overrepresented in the patients with gastric adenocarcinoma (51%) when compared either with the control group (38%) or patients with atrophy or intestinal metaplasia (27%). Callele was found to be very common in our population (0.22), and a multivariate logistic regression analysis revealed nearly 3-fold increased risk for the progression to gastric adenocarcinoma in patients with atrophy or intestinal metaplasia carrying the -765C allele (OR = 2.67, 95% CI = 1.03-6.93; P = 0.04).considered as another susceptibility marker for gastric adenocarcinoma development in patients with atrophy or intestinal metaplasia.

Gastric cancer in a Caucasian population: Role of pepsinogen C genetic variants

瞄准：在胃蛋白酶原 C (PGC ) 基因学习插入 / 删除多型性的角色，为胃粘膜的终端区别的一个有效标记，在到胃的损害的开发的危险性。方法：没有肿瘤的疾病的证据，学习与已知的胃的损害的 99 件样品和 127 件样品被执行。PCR 被采用， 6 多态的等位基因被放大：等位基因 1 (510 bp ) ，等位基因 2 (480 bp ) ，等位基因 3/4 (450/460 bp ) ，等位基因 5 (400 bp ) 并且等位基因 6 (310 bp ) 。结果：我们的结果表明等位基因 6 搬运人似乎对任何胃的损害的发展有保护(或 = 0.34；P【0.001 ) ，与象萎缩或肠的组织变形那样的胃的腺癌联系的 non-dysplastic 损害(或 = 0.28；P【0.001 ) 或侵略 GC (或 = 0.39；P = 0.004 ) 。结论：我们的学习表明等位基因 6 搬运人地位在胃的损害的发展有一个保护的角色，可能由于它有 PGC 的更高的表示的协会。而且，在控制组的等位基因 6 搬运人的频率比在亚洲人口获得了高是远的，它可能代表在白种人和亚洲人口之间的基因差距。