In the advancing landscape of technology and novel material development,additive manufacturing(AM)is steadily making strides within the biomedical sector.Moving away from traditional,one-sizefits-all implant solutions...In the advancing landscape of technology and novel material development,additive manufacturing(AM)is steadily making strides within the biomedical sector.Moving away from traditional,one-sizefits-all implant solutions,the advent of AM technology allows for patient-specific scaffolds that could improve integration and enhance wound healing.These scaffolds,meticulously designed with a myriad of geometries,mechanical properties,and biological responses,are made possible through the vast selection of materials and fabrication methods at our disposal.Recognizing the importance of precision in the treatment of bone defects,which display variability from macroscopic to microscopic scales in each case,a tailored treatment strategy is required.A patient-specific AM bone scaffold perfectly addresses this necessity.This review elucidates the pivotal role that customized AM bone scaffolds play in bone defect treatment,while offering comprehensive guidelines for their customization.This includes aspects such as bone defect imaging,material selection,topography design,and fabrication methodology.Additionally,we propose a cooperative model involving the patient,clinician,and engineer,thereby underscoring the interdisciplinary approach necessary for the effective design and clinical application of these customized AM bone scaffolds.This collaboration promises to usher in a new era of bioactive medical materials,responsive to individualized needs and capable of pushing boundaries in personalized medicine beyond those set by traditional medical materials.展开更多
Bone is a unique tissue that is capable of repairing itself after damage.However,there are certain instances of fractures and defects that require clinical intervention for proper alignment and healing.As with any imp...Bone is a unique tissue that is capable of repairing itself after damage.However,there are certain instances of fractures and defects that require clinical intervention for proper alignment and healing.As with any implant,careful consideration of the material used to create the implants to treat these problems is needed.If the incorrect material is chosen,the implants themselves can lead to bone fractures or defects,or bone healing may not take place at all.All three classes of biomaterials-metals,ceramics,and polymers-have been used in the treatment of both bone fractures and bone defects,and each has its own unique benefits and limitations for its applications.Furthermore,composites of these different materials have also been created to try to take advantage of all the different benefits offered by each different material.This review highlights different materials that have been used for the development of internal fixators and bone graft substitutes to treat fracture and bone defects as well as their limitations and needed future research.展开更多
Hernia repair for primary and incisional hernia is the most commonly performed abdominal surgery done with extremely high costs.Treatment for hernia requires surgery to close the defect;however,there are post-operativ...Hernia repair for primary and incisional hernia is the most commonly performed abdominal surgery done with extremely high costs.Treatment for hernia requires surgery to close the defect;however,there are post-operative complications like chronic pain,adhesion,and infection that are common.Hernia repair involves two types of biomaterials:a fixation biomaterial and a mesh biomaterial to close the defect.Synthetic meshes,mostly made from different polymers,provide adequate mechanical support but are associated with postoperative complications like infection.Biological meshes are derived from allografts and xenografts that are prone to less infection;however,their mechanical strength may be too weak depending the characteristics of the hernia defect.Novel meshes being developed try to combat the post-operative complications of current surgical meshes.Composite meshes that have two different surfaces have shown to have less adhesion effects but still produce varying inflammatory responses.Drug-loaded meshes are also a novel mesh that is designed to reduce infection with antibiotics.This review will highlight the different fixation methods as well as the pros and cons of different mesh options.Possible future improvements will be highlighted as well.展开更多
The authors regret that interpretation of the work of Holmdahl et al.1 was misinterpreted in section“5.2 Biological Meshes for Abdominal Repair”.The correct interpretation is that there is no statistical difference ...The authors regret that interpretation of the work of Holmdahl et al.1 was misinterpreted in section“5.2 Biological Meshes for Abdominal Repair”.The correct interpretation is that there is no statistical difference in hernia recurrence rate for both groups in the study.The corrected work does not change the conclusion that biological meshes perform the same or worst then synthetic meshes.The authors would like to apologise for any inconvenience caused.展开更多
文摘In the advancing landscape of technology and novel material development,additive manufacturing(AM)is steadily making strides within the biomedical sector.Moving away from traditional,one-sizefits-all implant solutions,the advent of AM technology allows for patient-specific scaffolds that could improve integration and enhance wound healing.These scaffolds,meticulously designed with a myriad of geometries,mechanical properties,and biological responses,are made possible through the vast selection of materials and fabrication methods at our disposal.Recognizing the importance of precision in the treatment of bone defects,which display variability from macroscopic to microscopic scales in each case,a tailored treatment strategy is required.A patient-specific AM bone scaffold perfectly addresses this necessity.This review elucidates the pivotal role that customized AM bone scaffolds play in bone defect treatment,while offering comprehensive guidelines for their customization.This includes aspects such as bone defect imaging,material selection,topography design,and fabrication methodology.Additionally,we propose a cooperative model involving the patient,clinician,and engineer,thereby underscoring the interdisciplinary approach necessary for the effective design and clinical application of these customized AM bone scaffolds.This collaboration promises to usher in a new era of bioactive medical materials,responsive to individualized needs and capable of pushing boundaries in personalized medicine beyond those set by traditional medical materials.
文摘Bone is a unique tissue that is capable of repairing itself after damage.However,there are certain instances of fractures and defects that require clinical intervention for proper alignment and healing.As with any implant,careful consideration of the material used to create the implants to treat these problems is needed.If the incorrect material is chosen,the implants themselves can lead to bone fractures or defects,or bone healing may not take place at all.All three classes of biomaterials-metals,ceramics,and polymers-have been used in the treatment of both bone fractures and bone defects,and each has its own unique benefits and limitations for its applications.Furthermore,composites of these different materials have also been created to try to take advantage of all the different benefits offered by each different material.This review highlights different materials that have been used for the development of internal fixators and bone graft substitutes to treat fracture and bone defects as well as their limitations and needed future research.
文摘Hernia repair for primary and incisional hernia is the most commonly performed abdominal surgery done with extremely high costs.Treatment for hernia requires surgery to close the defect;however,there are post-operative complications like chronic pain,adhesion,and infection that are common.Hernia repair involves two types of biomaterials:a fixation biomaterial and a mesh biomaterial to close the defect.Synthetic meshes,mostly made from different polymers,provide adequate mechanical support but are associated with postoperative complications like infection.Biological meshes are derived from allografts and xenografts that are prone to less infection;however,their mechanical strength may be too weak depending the characteristics of the hernia defect.Novel meshes being developed try to combat the post-operative complications of current surgical meshes.Composite meshes that have two different surfaces have shown to have less adhesion effects but still produce varying inflammatory responses.Drug-loaded meshes are also a novel mesh that is designed to reduce infection with antibiotics.This review will highlight the different fixation methods as well as the pros and cons of different mesh options.Possible future improvements will be highlighted as well.
文摘The authors regret that interpretation of the work of Holmdahl et al.1 was misinterpreted in section“5.2 Biological Meshes for Abdominal Repair”.The correct interpretation is that there is no statistical difference in hernia recurrence rate for both groups in the study.The corrected work does not change the conclusion that biological meshes perform the same or worst then synthetic meshes.The authors would like to apologise for any inconvenience caused.
