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Stereotactic body radiotherapy in pancreatic adenocarcinoma 被引量:1
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作者 carolina de la pinta 《Hepatobiliary & Pancreatic Diseases International》 SCIE CAS CSCD 2024年第1期14-19,共6页
Background:Stereotactic body radiotherapy(SBRT)in pancreatic cancer allows high delivery of radiation doses on tumors without affecting surrounding tissue.This review aimed at the SBRT application in the treatment of ... Background:Stereotactic body radiotherapy(SBRT)in pancreatic cancer allows high delivery of radiation doses on tumors without affecting surrounding tissue.This review aimed at the SBRT application in the treatment of pancreatic cancer.Data sources:We retrieved articles published in MEDLINE/PubMed from January 2017 to December 2022.Keywords used in the search included:“pancreatic adenocarcinoma”OR“pancreatic cancer”AND“stereotactic ablative radiotherapy(SABR)”OR“stereotactic body radiotherapy(SBRT)”OR“chemoradiotherapy(CRT)”.English language articles with information on technical characteristics,doses and fractionation,indications,recurrence patterns,local control and toxicities of SBRT in pancreatic tumors were included.All articles were assessed for validity and relevant content.Results:Optimal doses and fractionation have not yet been defined.However,SBRT could be the standard treatment in patients with pancreatic adenocarcinoma in addition to CRT.Furthermore,the combination of SBRT with chemotherapy may have additive or synergic effect on pancreatic adenocarcinoma.Conclusions:SBRT is an effective modality for patients with pancreatic cancer,supported by clinical practice guidelines as it has demonstrated good tolerance and good disease control.SBRT opens a possibility of improving outcomes for these patients,both in neoadjuvant treatment and with radical intent. 展开更多
关键词 CHEMORADIOTHERAPY Pancreatic adenocarcinoma RADIOTHERAPY Stereotactic body radiotherapy Stereotactic ablative radiotherapy
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GOECP/SEOR radiotherapy guidelines for small-cell lung cancer 被引量:1
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作者 Felipe Couñago carolina de la pinta +10 位作者 Susana Gonzalo Castalia Fernández Piedad Almendros Patricia Calvo Begoña Taboada Antonio Gómez-Caamaño JoséLuis López Guerra Marisa Chust JoséAntonio GonzálezFerreira AnaÁlvarez González Francesc Casas 《World Journal of Clinical Oncology》 CAS 2021年第3期115-143,共29页
Small cell lung cancer(SCLC)accounts for approximately 20%of all lung cancers.The main treatment is chemotherapy(Ch).However,the addition of radiotherapy significantly improves overall survival(OS)in patients with non... Small cell lung cancer(SCLC)accounts for approximately 20%of all lung cancers.The main treatment is chemotherapy(Ch).However,the addition of radiotherapy significantly improves overall survival(OS)in patients with non-metastatic SCLC and in those with metastatic SCLC who respond to Ch.Prophylactic cranial irradiation reduces the risk of brain metastases and improves OS in both metastatic and non-metastatic patients.The 5-year OS rate in patients with limited-stage disease(non-metastatic)is slightly higher than 30%,but less than 5%in patients with extensive-stage disease(metastatic).The present clinical guidelines were developed by Spanish radiation oncologists on behalf of the Oncologic Group for the Study of Lung Cancer/Spanish Society of Radiation Oncology to provide a current review of the diagnosis,planning,and treatment of SCLC.These guidelines emphasise treatment fields,radiation techniques,fractionation,concomitant treatment,and the optimal timing of Ch and radiotherapy.Finally,we discuss the main indications for reirradiation in local recurrence. 展开更多
关键词 Small cell lung cancer CHEMOTHERAPY Hyperfractionated radiation therapy Prophylactic brain irradiation Brain metastases REIRRADIATION
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Radiomics in pancreatic cancer for oncologist:Present and future 被引量:2
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作者 carolina de la pinta 《Hepatobiliary & Pancreatic Diseases International》 SCIE CAS CSCD 2022年第4期356-361,共6页
Radiomics is changing the world of medicine and more specifically the world of oncology.Early diagnosis and treatment improve the prognosis of patients with cancer.After treatment,the evaluation of the response will d... Radiomics is changing the world of medicine and more specifically the world of oncology.Early diagnosis and treatment improve the prognosis of patients with cancer.After treatment,the evaluation of the response will determine future treatments.In oncology,every change in treatment means a loss of therapeutic options and this is key in pancreatic cancer.Radiomics has been developed in oncology in the early diagnosis and differential diagnosis of benign and malignant lesions,in the evaluation of response,in the prediction of possible side effects,marking the risk of recurrence,survival and prognosis of the disease.Some studies have validated its use to differentiate normal tissues from tumor tissues with high sensitivity and specificity,and to differentiate cystic lesions and pancreatic neuroendocrine tumor grades with texture parameters.In addition,these parameters have been related to survival in patients with pancreatic cancer and to response to radiotherapy and chemotherapy.This review aimed to establish the current status of the use of radiomics in pancreatic cancer and future perspectives. 展开更多
关键词 Pancreatic cancer Radiomics Radiogenomics
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Advances and controversies in the management of early stage nonsmall cell lung cancer 被引量:1
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作者 Angel Cilleruelo-Ramos Esther Cladellas-Gutiérrez +5 位作者 carolina de la pinta laura Quintana-Cortés Paloma Sosa-Fajardo Felipe Couñago Xabier Mielgo-Rubio Juan Carlos Trujillo-Reyes 《World Journal of Clinical Oncology》 CAS 2021年第12期1089-1100,共12页
Complete resection continues to be the gold standard for the treatment of earlystage lung cancer.The landmark Lung Cancer Study Group trial in 1995 established lobectomy as the minimum intervention necessary for the m... Complete resection continues to be the gold standard for the treatment of earlystage lung cancer.The landmark Lung Cancer Study Group trial in 1995 established lobectomy as the minimum intervention necessary for the management of early-stage non-small cell lung cancer,as it was associated with lower recurrence and metastasis rates than sublobar resection and lower postoperative morbidity and mortality than pneumonectomy.There is a growing tendency to perform sublobar resection in selected cases,as,depending on factors such as tumor size,histologic subtype,lymph node involvement,and resection margins,it can produce similar oncological results to lobectomy.Alternative treatments such as stereotactic body radiotherapy and radiofrequency ablation can also produce good outcomes in inoperable patients or patients who refuse surgery. 展开更多
关键词 Video-assisted thoracoscopic surgery Sublobar resection Radiofrequency ablation Stereotactic radiosurgery Early stage Lung cancer
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