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人类生命早期暴露组(HELIX):项目理念与设计(续完)
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作者 Martine Vrijheid Rémy Slama +36 位作者 Oliver Robinson Leda Chatzi Muireann Coen Peter van den Hazel cathrine thomsen John Wright Toby J.Athersuch Narcis Avellana Xavier Basagana Celine Brochot Luca Bucchini Mariona Bustamante Angel Carracedo Maribel Casas Xavier Estivill Lesley Fairley Diana van Gent Juan R.Gonzalez Berit Granum Regina Grazuleviiene Kristine B.Gutzkow Jordi Julvez Hector C.Keun Manolis Kogevinas Rosemary R.C.McEachan Helle Margrete Meltzer Eduard Sabidó Per E.Schwarze Valérie Siroux Jordi Sunyer Elizabeth J.Want Florence Zeman Mark J.Nieuwenhuijsen 何蓉 操仪 汪源 金泰廙 《环境与职业医学》 CAS CSCD 北大核心 2015年第2期186-190,共5页
3.2研究2:室外暴露 传统h基于居住区评估的暴露,如室外空气污染、噪声、建筑环境,可以通过收集时间一空间活动以及(就空气污染而言)个人吸入空气量的信息,改善暴露评估和减小测量误差。例如,可替代吸入率(Kawahara等,2011)... 3.2研究2:室外暴露 传统h基于居住区评估的暴露,如室外空气污染、噪声、建筑环境,可以通过收集时间一空间活动以及(就空气污染而言)个人吸入空气量的信息,改善暴露评估和减小测量误差。例如,可替代吸入率(Kawahara等,2011)的体力活动方面的信息与个人空气污染测量结合来评估吸入剂量。基于暴露评估的新一代地理信息系统(GIS)(Beelen等,2013;Eeflens等,2012)、遥感(Dadvand等,2012)和智能手机技术(deNazelle等,2013)使评估室外暴露和整合个人活动范围及体力活动数据变得更容易。 展开更多
关键词 早期暴露 人类生命 地理信息系统 设计 空气污染 测量误差 体力活动 建筑环境
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人类生命早期暴露组(HELIX):项目理念与设计(待续)
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作者 Martine Vrijheid Rémy Slama +36 位作者 Oliver Robinson Leda Chatzi Muireann Coen Peter van den Hazel cathrine thomsen John Wright Toby J.Athersuch Narcis Avellana Xavier Basagana Celine Brochot Luca Bucchini Mariona Bustamante Angel Carracedo Maribel Casas Xavier Estivill Lesley Fairley Diana van Gent Juan R.Gonzalez Berit Granum Regina Grazuleviiene Kristine B.Gutzkow Jordi Julvez Hector C.Keun Manolis Kogevinas Rosemary R.C.McEachan Helle Margrete Meltzer Eduard Sabidó PerE.Schwarze Valérie Siroux Jordi Sunyer Elizabeth J.Want Florence Zeman Mark J.Nieuwenhuijsen 何蓉 操仪 汪源 金泰廙 《环境与职业医学》 CAS CSCD 北大核心 2015年第1期90-95,共6页
[背景]人类在生命早期的发育期间可能特别容易受到环境暴露的影响。有关这一主题的人体研究一般集中在单一暴露与健康效应之间的关系。而"暴露组"的概念涵盖了从受孕开始的的全部暴露,完善了基因组。[目的]人类生命早期暴露组... [背景]人类在生命早期的发育期间可能特别容易受到环境暴露的影响。有关这一主题的人体研究一般集中在单一暴露与健康效应之间的关系。而"暴露组"的概念涵盖了从受孕开始的的全部暴露,完善了基因组。[目的]人类生命早期暴露组(HELIX)项目是一个新的合作研究项目,目的是为了采用新的暴露评估和生物标志分析方法来描述生命早期多种环境因素的暴露,并将这些与生物标志组学和儿童健康结局相关联,从而刻画"生命早期暴露组"。本文描述了该项目的总体设计。[方法]HELIX将利用欧洲现有的6个出生队列研究来估计产前、产后暴露的一系列化学和物理暴露。建立全部队列中总共32 000对母亲和儿童的暴露模型,并在一个包含1 200对母亲和儿童的子队列中测量生物标志。嵌套重复采样的定组研究(n=150)将收集生物标志的变化数据,利用智能手机来评估流动性和体力活动,并监测个体暴露。采用组学技术确定与暴露相关的分子学特征(代谢组、蛋白质组、转录组和表观基因组)。对于多次暴露,采用统计方法估计胎儿和儿童的成长、肥胖、神经发育和呼吸系统结局中的暴露-效应关系。项目还将进行一项健康效应评估测试,以评价组合暴露的风险和收益。[结论]HELIX是描述欧洲人群生命早期暴露组并解开它与组学标志物和儿童健康之间关联的首次尝试之一。作为对暴露组学这一概念的验证,该项目向生命过程中暴露组迈出了重要的第一步。 展开更多
关键词 人类生命 早期暴露 设计 出生队列研究 儿童健康 生物标志 效应评估 生命早期
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Sampling strategy for estimating human exposure pathways to consumer chemicals
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作者 Eleni Papadopoulou Juan A.Padilla-Sanchez +8 位作者 Chris D.Collins Ian T.Cousins Adrian Covaci Cynthia A.de Wit Pim E.G.Leonards Stefan Voorspoels cathrine thomsen Stuart Harrad Line S.Haug 《Emerging Contaminants》 2016年第1期26-36,共11页
Human exposure to consumer chemicals has become a worldwide concern.In this work,a comprehensive sampling strategy is presented,to our knowledge being the first to study all relevant exposure pathways in a single coho... Human exposure to consumer chemicals has become a worldwide concern.In this work,a comprehensive sampling strategy is presented,to our knowledge being the first to study all relevant exposure pathways in a single cohort using multiple methods for assessment of exposure from each exposure pathway.The selected groups of chemicals to be studied are consumer chemicals whose production and use are currently in a state of transition and are;per-and polyfluorinated alkyl substances(PFASs),traditional and“emerging”brominated flame retardants(BFRs and EBFRs),organophosphate esters(OPEs)and phthalate esters(PEs).Information about human exposure to these contaminants is needed due to existing data gaps on human exposure intakes from multiple exposure pathways and relationships between internal and external exposure.Indoor environment,food and biological samples were collected from 61 participants and their households in the Oslo area(Norway)on two consecutive days,during winter 2013-14.Air,dust,hand wipes,and duplicate diet(food and drink)samples were collected as indicators of external exposure,and blood,urine,blood spots,hair,nails and saliva as indicators of internal exposure.A food diary,food frequency questionnaire(FFQ)and indoor environment questionnaire were also implemented.Approximately 2000 samples were collected in total and participant views on their experiences of this campaign were collected via questionnaire.While 91%of our participants were positive about future participation in a similar project,some tasks were viewed as problematic.Completing the food diary and collection of duplicate food/drink portions were the tasksmost frequent reported as“hard”/“very hard”.Nevertheless,a strong positive correlation between the reported total mass of food/drinks in the food record and the total weight of the food/drinks in the collection bottles was observed,being an indication of accurate performance of the participants despite the challenges of the sampling campaign. 展开更多
关键词 BIOMONITORING Indoor environment Consumer products DIET DUST Non-invasive samples
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