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Chemical Synthesis of Globo H and Mannobiose Glycopolymers and their Immunological Stimulation
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作者 Zhi Zhang ce-ce xue +1 位作者 Ying-Le Feng Guo-Song Chen 《Chinese Journal of Polymer Science》 SCIE EI CAS CSCD 2024年第11期1661-1667,I0007,共8页
Tumor-associated carbohydrate antigens(TACAs)provide a special class of tumor-specific antigens that show promising applications in cancer immunotherapy.However,the weak immunogenicity and structural complexity of TAC... Tumor-associated carbohydrate antigens(TACAs)provide a special class of tumor-specific antigens that show promising applications in cancer immunotherapy.However,the weak immunogenicity and structural complexity of TACAs are obstacles to their clinical application.Here,based on a fast and low-cost purification strategy for oligosaccharide synthesis,the synthesis of tumour-associated carbohydrate antigens Globo H and mannobiose which resembles repeat unit of mannan was achieved.To enhance the immunogenicity and multivalent effect,Globo H and mannobiose were covalently attached to degradable polymer backbones.2D spindle-like lamellar micelle and globular micelle were obtained from glycopolymer through a solvent-exchange method of self-assembly.The glyconanoparticle showed good biocompatibility and degradability.Immunological functions of these glyconanoparticles such as stimulation of BMDC to cause upregulation of inflammatory factors were preliminarily explored. 展开更多
关键词 Globo-H Mannobiose GLYCOPOLYMER Convergent Synthesis Tumor-associated carbohydrate antigens
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