Ovo-like transcriptional repressor 1(OVOL1)is a key mediator of epithelial lineage determination and mesenchymal–epithelial transition(MET).The cytokines transforming growth factor-β(TGF-β)and bone morphogenetic pr...Ovo-like transcriptional repressor 1(OVOL1)is a key mediator of epithelial lineage determination and mesenchymal–epithelial transition(MET).The cytokines transforming growth factor-β(TGF-β)and bone morphogenetic proteins(BMP)control the epithelial–mesenchymal plasticity(EMP)of cancer cells,but whether this occurs through interplay with OVOL1 is not known.Here,we show that OVOL1 is inversely correlated with the epithelial–mesenchymal transition(EMT)signature,and is an indicator of a favorable prognosis for breast cancer patients.OVOL1 suppresses EMT.展开更多
基金We acknowledge the support of the Chinese Scholarship Council(CSC)to Chuannan Fan and Qian Wang,and the Cancer Genomics Centre in the Netherlands(CGC,NL)and the ZonMW grant(09120012010061)to Peter ten Dijke.We thank Maarten van Dinther and Martijn Rabelink for excellent technical assistance and Slobodan Vukicevic(University of Zagreb,Croatia),and Andrew Hinck(University of Pittsburgh,USA)for generously providing human recombinant BMP6 and TGF-β3,respectively.We acknowledge A.G.Jochemsen for providing the FH1tUTG vector.We are grateful to Midory Thorikay for help with testing effect of compounds on OVOL1 expression and checking the expression of OVOL1 in breast cancer cell lines,Jing Zhang for the help with GSEA,Sijia Liu for instructions on how to perform the zebrafish xenograft assay,and all other members in ten Dijke’s laboratory and Yuva Oz for their kind support.
文摘Ovo-like transcriptional repressor 1(OVOL1)is a key mediator of epithelial lineage determination and mesenchymal–epithelial transition(MET).The cytokines transforming growth factor-β(TGF-β)and bone morphogenetic proteins(BMP)control the epithelial–mesenchymal plasticity(EMP)of cancer cells,but whether this occurs through interplay with OVOL1 is not known.Here,we show that OVOL1 is inversely correlated with the epithelial–mesenchymal transition(EMT)signature,and is an indicator of a favorable prognosis for breast cancer patients.OVOL1 suppresses EMT.
