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深松铲工作载荷测试与载荷谱编制 被引量:2
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作者 李敏通 马甜 +3 位作者 刘志杰 朱盟盟 查峥 王翔 《中国农机化学报》 北大核心 2019年第11期1-8,19,共9页
深松铲在旱地农作物、甘蔗、牧草种植等作业中得到广泛应用。深松铲载荷谱是合理设计深松铲的重要依据,可为深松铲的优化设计与可靠性分析提供数据支撑。利用三维建模与有限元分析方法,建立深松铲的应力分析模型,确定结构损伤点;在大田... 深松铲在旱地农作物、甘蔗、牧草种植等作业中得到广泛应用。深松铲载荷谱是合理设计深松铲的重要依据,可为深松铲的优化设计与可靠性分析提供数据支撑。利用三维建模与有限元分析方法,建立深松铲的应力分析模型,确定结构损伤点;在大田条件下进行深松铲的载荷测试试验,对测试信号进行分析处理,应用雨流计数法等编制深松铲的一维载荷谱,得出:正向弯曲载荷谱、侧向弯曲载荷谱、侧向拉伸载荷谱的波动中心分别为3516 MPa、30 MPa、45 MPa,其各自的载荷循环累积频次分别为277671次、247565次、289693次,其各自的最大幅值为8744 MPa、264 MPa、392 MPa,将最大幅值按非等间隔法处理得到8个等级,实验室程序加载时可将幅值按等级叠加在不变的波动中心上。 展开更多
关键词 深松铲 有限元分析 载荷测试 雨流计数法 载荷谱
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A new discovered ABCA1 gene polymorphisms and the association of ABCA1 SNPs with coronary artery disease and plasma lipids in Chinese population 被引量:1
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作者 Guo Zhigang Wu Pingsheng +6 位作者 Xie Di Wang Qiguang Liu Yayang cha zheng Li Peng Lai Wenyan Tu Yan 《Journal of Medical Colleges of PLA(China)》 CAS 2011年第4期179-190,共12页
Single nucleotide polymorphisms (SNP) of ATP-binding cassette transporter A1 (ABCA1) gene are related to plasma lipid and susceptibility to coronary artery disease (CAD). Our first goal was to screen all 50 codi... Single nucleotide polymorphisms (SNP) of ATP-binding cassette transporter A1 (ABCA1) gene are related to plasma lipid and susceptibility to coronary artery disease (CAD). Our first goal was to screen all 50 coding regions of ABCA1 to find new SNPs. Our second goal was to investigate the frequency distribution of R1587K and M883I polymorphisms of ABCA1 gene, which are the variant occurred most frequently, in Chinese people and to evaluate their association with the CAD phenotype and plasma lipids. Methods: Single-strand conformation polymorphism (SSCP) and DNA sequence were used for confirming new SNP of ABCA1, and restriction fragment length polymorphism (RFLP) were applied for confirming genotypes of R1587K and M883I in 112 CAD cases and 108 healthy people. Results: We discovered a new ABCA1 SNP in Chinese population, which converse 233 amino acids from Methionine to Valine (M233V). This new ABCA1 SNP located in exon7, and might potentially modulate the biological function of lipid metabolism. For R1587K and M883I SNPs, the K allele and I allele frequency was 28.9% and 31.1%, respectively. The K allele at R1587K conferred lower mean values of HDL-C in a dose-dependent manner in both CAD patients and healthy people. However, 883I allele was not associated with plasma lipid level. Neither 1587KK nor 883II associated with increased risk of CAD. Conclusion: Our study finds a potential functional ABCA1 SNPs and revealed K allele of R1587K associated decreased HDL-C level in Chinese population. 展开更多
关键词 ATP binding cassette transporter A1 Single nucleotide polymorphism Plasma lipid Coronary artery disease
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