Epilepsy is a complex neurologic condition which affects over 50 million people worldwide.Pharmacotherapy,primarily involving the use of anti-seizure drugs(ASDs),is an essential part of controlling seizures.However,ne...Epilepsy is a complex neurologic condition which affects over 50 million people worldwide.Pharmacotherapy,primarily involving the use of anti-seizure drugs(ASDs),is an essential part of controlling seizures.However,nearly 30%of patients develop drug-resistant epilepsy,clinically defined as the persistence of seizure following trials of two ASDs(Kwan et al.,2010).Although several hypotheses have been proposed to explain this phenomenon,the mechanism of drug-resistant epilepsy still remains unclear.展开更多
The ongoing COVID-19 pandemic has impacted the entire globe on all fronts,and vector-borne diseases are not an exception.There are certain similarities between dengue and COVID-19 since both diseases are positive-sens...The ongoing COVID-19 pandemic has impacted the entire globe on all fronts,and vector-borne diseases are not an exception.There are certain similarities between dengue and COVID-19 since both diseases are positive-sense single-stranded RNA virus and have animal origin linkages.Interestingly,both the diseases present over 80%asymptomatic cases.Dengue is the most prevalent and fast-emerging viral infection worldwide.The dengue virus(DENV)has four serotypes,namely DENV-1,DENV-2,DENV-3 and DENV-4,and it is possible that the same person can be infected four times before full immunity is established[1];whereas,COVID-19 is an air-borne respiratory disease caused by the severe acute respiratory syndrome coronavirus 2,and several variants have emerged over time.In late 2020,the variants posed an increased risk to global public health emergency,which prompted the characterisation of specific Variants of Interest and Variants of Concern to mitigate the COVID-19 pandemic[2].DENV is transmitted by several species of day-biting Aedes mosquitoes.They are highly adaptive and invasive species and are predominantly found in the tropical and subtropical regions.In recent decades,these mosquitoes have been discovered in all continents except Antarctica.Aedes aegypti and Aedes albopictus are two major vectors of dengue.This means wherever these mosquitoes make their footprints,dengue creeps in.展开更多
基金The present work is supported in part by the National Institute of Neurological Disorders and Stroke/National Institutes of Health grants R01NS095825(to CG).
文摘Epilepsy is a complex neurologic condition which affects over 50 million people worldwide.Pharmacotherapy,primarily involving the use of anti-seizure drugs(ASDs),is an essential part of controlling seizures.However,nearly 30%of patients develop drug-resistant epilepsy,clinically defined as the persistence of seizure following trials of two ASDs(Kwan et al.,2010).Although several hypotheses have been proposed to explain this phenomenon,the mechanism of drug-resistant epilepsy still remains unclear.
文摘The ongoing COVID-19 pandemic has impacted the entire globe on all fronts,and vector-borne diseases are not an exception.There are certain similarities between dengue and COVID-19 since both diseases are positive-sense single-stranded RNA virus and have animal origin linkages.Interestingly,both the diseases present over 80%asymptomatic cases.Dengue is the most prevalent and fast-emerging viral infection worldwide.The dengue virus(DENV)has four serotypes,namely DENV-1,DENV-2,DENV-3 and DENV-4,and it is possible that the same person can be infected four times before full immunity is established[1];whereas,COVID-19 is an air-borne respiratory disease caused by the severe acute respiratory syndrome coronavirus 2,and several variants have emerged over time.In late 2020,the variants posed an increased risk to global public health emergency,which prompted the characterisation of specific Variants of Interest and Variants of Concern to mitigate the COVID-19 pandemic[2].DENV is transmitted by several species of day-biting Aedes mosquitoes.They are highly adaptive and invasive species and are predominantly found in the tropical and subtropical regions.In recent decades,these mosquitoes have been discovered in all continents except Antarctica.Aedes aegypti and Aedes albopictus are two major vectors of dengue.This means wherever these mosquitoes make their footprints,dengue creeps in.
