Our gut microbiome is constituted by trillions of microorganisms including bacteria,archaea and eukaryotic microbes.Nowadays,gut microbiome has been gradually recognized as a new organ system that systemically and bio...Our gut microbiome is constituted by trillions of microorganisms including bacteria,archaea and eukaryotic microbes.Nowadays,gut microbiome has been gradually recognized as a new organ system that systemically and biochemically interact with the host.Accumulating evidence suggests that the imbalanced gut microbiome contributes to the dysregulation of immune system and the disruption of cardiovascular homeostasis.Specific microbiome profiles and altered intestinal permeability are often observed in the pathophysiology of cardiovascular diseases.Gut-derived metabolites,toxins,peptides and immune cell-derived cytokines play pivotal roles in the induction of inflammation and the pathogenesis of dysfunction of heart and vasculature.Impaired crosstalk between gut microbiome and multiple organ systems,such as gut-vascular,heart-gut,gut-liver and brain-gut axes,are associated with higher cardiovascular risks.Medications and strategies that restore healthy gut microbiome might therefore represent novel therapeutic options to lower the incidence of cardiovascular and metabolic disorders.展开更多
Our oral cavity houses various types of microbesincluding bacteria, protozoa, fungi and viruses, harboringover 700 bacterial species. Oral dysbiosis refers to theimbalance between symbionts and pathobionts in the oral...Our oral cavity houses various types of microbesincluding bacteria, protozoa, fungi and viruses, harboringover 700 bacterial species. Oral dysbiosis refers to theimbalance between symbionts and pathobionts in the oralcavity, posing potential threats to host cardiovascularhealth. Importantly, oral dysbiosis promotes cardiovascular pathophysiology through different mechanisms.Although overgrowth of certain pathogenic bacteria havebeen indicated in some cardiometabolic diseases, it is stillpremature to consider oral microbiome as a suitable predictor for non-invasive diagnostic purpose. However, targeting oral microbiome might still provide preventive andtherapeutic insights on cardiovascular diseases. Furtherextensive efforts are needed to deepen our understandingon oral-cardiovascular connection in the context of diagnostic and therapeutic perspectives.展开更多
基金supported by Hong Kong RGC-Senior Research Fellow Scheme(SRFS2021-4S04)National Natural Science Foundation of China(91939302).
文摘Our gut microbiome is constituted by trillions of microorganisms including bacteria,archaea and eukaryotic microbes.Nowadays,gut microbiome has been gradually recognized as a new organ system that systemically and biochemically interact with the host.Accumulating evidence suggests that the imbalanced gut microbiome contributes to the dysregulation of immune system and the disruption of cardiovascular homeostasis.Specific microbiome profiles and altered intestinal permeability are often observed in the pathophysiology of cardiovascular diseases.Gut-derived metabolites,toxins,peptides and immune cell-derived cytokines play pivotal roles in the induction of inflammation and the pathogenesis of dysfunction of heart and vasculature.Impaired crosstalk between gut microbiome and multiple organ systems,such as gut-vascular,heart-gut,gut-liver and brain-gut axes,are associated with higher cardiovascular risks.Medications and strategies that restore healthy gut microbiome might therefore represent novel therapeutic options to lower the incidence of cardiovascular and metabolic disorders.
基金Research Grants Council of Hong Kong(PDFS 2022/23)Health and Medical Research Fund(08190776)and CityU Start-up Fund.
文摘Our oral cavity houses various types of microbesincluding bacteria, protozoa, fungi and viruses, harboringover 700 bacterial species. Oral dysbiosis refers to theimbalance between symbionts and pathobionts in the oralcavity, posing potential threats to host cardiovascularhealth. Importantly, oral dysbiosis promotes cardiovascular pathophysiology through different mechanisms.Although overgrowth of certain pathogenic bacteria havebeen indicated in some cardiometabolic diseases, it is stillpremature to consider oral microbiome as a suitable predictor for non-invasive diagnostic purpose. However, targeting oral microbiome might still provide preventive andtherapeutic insights on cardiovascular diseases. Furtherextensive efforts are needed to deepen our understandingon oral-cardiovascular connection in the context of diagnostic and therapeutic perspectives.
