Two new flavone glycosides, isoetin-7-O-β-D-glucopyranosyl-2′-O-α-L-arabinopyranoside (1) and isoetin-7-O-β-D-glucopyranosyl-2′-O-α-D-glucopyranoside (2), a new lignan, mongolicumin A (3), and a new guaian...Two new flavone glycosides, isoetin-7-O-β-D-glucopyranosyl-2′-O-α-L-arabinopyranoside (1) and isoetin-7-O-β-D-glucopyranosyl-2′-O-α-D-glucopyranoside (2), a new lignan, mongolicumin A (3), and a new guaianolide, mongolicumin B (4) were isolated from the aerial part of Taraxacum mongolicum. Their structures were elucidated mainly by spectral analyses.展开更多
From Ligularia atroviolacea, four new eremophilendiolides, 81$-hydroxy-eremophil-3,7 (11)-dien-12,8α(14,6α)-diolide (1), 8β-methoxy-eremophil-3,7(11)-dien-12,8α(14,6α)-diolide (2), 8α-hydroxy-eremoph...From Ligularia atroviolacea, four new eremophilendiolides, 81$-hydroxy-eremophil-3,7 (11)-dien-12,8α(14,6α)-diolide (1), 8β-methoxy-eremophil-3,7(11)-dien-12,8α(14,6α)-diolide (2), 8α-hydroxy-eremophil-3,7(11)-dien-12,8lβ(14,6α)-diolide (3) and eremophil-3,7(11),8-trien-12,8 (14,6α)-diolide (4), as well as a known diolide (5) were isolated. Their structures were elucidated on the basis of 1D and 2D NMR as well as ESI-MS spectral data.展开更多
Three new diarylheptanoids, i.e., sodium(5S,2E)- 1,7-bis(4-hydroxyphenyl)- 1-hydroxy-2-hepten-5 -sulfonate (1), sodium(5R,2E)-1,7-bis(4-hydroxyphenyl)-1-hydroxy-2-hepten-5-sulfonate (2) and 3,5-diacetoxy-1...Three new diarylheptanoids, i.e., sodium(5S,2E)- 1,7-bis(4-hydroxyphenyl)- 1-hydroxy-2-hepten-5 -sulfonate (1), sodium(5R,2E)-1,7-bis(4-hydroxyphenyl)-1-hydroxy-2-hepten-5-sulfonate (2) and 3,5-diacetoxy-1-(3-methoxy-4,5-dihydroxyphenyl)-7-(4-hydroxy-3-methoxyphenyl)heptane (3) were isolated from the rhizomes of Zingiber officinale. The structures of the new compounds were elucidated on the basis of spectroscopic methods. The antioxidant activities of 3 were assayed by in vitro models involving DPPH free radicals and superoxide anion radicals.展开更多
23 compounds containing pyranone pharmacophore of territrem B were designed and synthesized. Some of the analogues showed IC50 values of AChE inhibition at 10^-5 mol/L.
文摘Two new flavone glycosides, isoetin-7-O-β-D-glucopyranosyl-2′-O-α-L-arabinopyranoside (1) and isoetin-7-O-β-D-glucopyranosyl-2′-O-α-D-glucopyranoside (2), a new lignan, mongolicumin A (3), and a new guaianolide, mongolicumin B (4) were isolated from the aerial part of Taraxacum mongolicum. Their structures were elucidated mainly by spectral analyses.
文摘From Ligularia atroviolacea, four new eremophilendiolides, 81$-hydroxy-eremophil-3,7 (11)-dien-12,8α(14,6α)-diolide (1), 8β-methoxy-eremophil-3,7(11)-dien-12,8α(14,6α)-diolide (2), 8α-hydroxy-eremophil-3,7(11)-dien-12,8lβ(14,6α)-diolide (3) and eremophil-3,7(11),8-trien-12,8 (14,6α)-diolide (4), as well as a known diolide (5) were isolated. Their structures were elucidated on the basis of 1D and 2D NMR as well as ESI-MS spectral data.
文摘Three new diarylheptanoids, i.e., sodium(5S,2E)- 1,7-bis(4-hydroxyphenyl)- 1-hydroxy-2-hepten-5 -sulfonate (1), sodium(5R,2E)-1,7-bis(4-hydroxyphenyl)-1-hydroxy-2-hepten-5-sulfonate (2) and 3,5-diacetoxy-1-(3-methoxy-4,5-dihydroxyphenyl)-7-(4-hydroxy-3-methoxyphenyl)heptane (3) were isolated from the rhizomes of Zingiber officinale. The structures of the new compounds were elucidated on the basis of spectroscopic methods. The antioxidant activities of 3 were assayed by in vitro models involving DPPH free radicals and superoxide anion radicals.
文摘23 compounds containing pyranone pharmacophore of territrem B were designed and synthesized. Some of the analogues showed IC50 values of AChE inhibition at 10^-5 mol/L.
基金supported by the National Natural Science Foundation of China(No30801429)Zhejiang Provincial Administration of Traditional Chinese Medicine Project(No2012ZZ009)Traditional Chinese Medicine Administration of Zhejiang Province(2010ZQ004)