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基于HPLC指纹图谱与主成分分析相结合的四黄烧伤膏提取工艺研究 被引量:1
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作者 刘长河 菅单单 +3 位作者 陈胜虎 李华妮 王艳艳 张雪侠 《中国药师》 CAS 2023年第12期374-381,共8页
目的利用正交试验优选四黄烧伤膏的提取工艺,并建立四黄烧伤膏HPLC指纹图谱,为该制剂的质量评价提供参考。方法以四黄烧伤膏复方为模型药物,采用HPLC法建立指纹图谱,对指纹图谱共有峰峰面积进行主成分分析,以总因子得分为评价指标,采用... 目的利用正交试验优选四黄烧伤膏的提取工艺,并建立四黄烧伤膏HPLC指纹图谱,为该制剂的质量评价提供参考。方法以四黄烧伤膏复方为模型药物,采用HPLC法建立指纹图谱,对指纹图谱共有峰峰面积进行主成分分析,以总因子得分为评价指标,采用正交试验法,对提取次数、提取时间、溶剂倍量等条件进行优化,筛选出最优提取工艺参数。结果在特征图谱研究中,共确定了12个共有峰。利用主成分分析法提取的2个主成分累计方差贡献率达到84.751%,计算9个样本的综合得分指标。正交试验得出的最佳提取工艺为加水10倍量,提取3次,每次2 h。结论该研究所建立的方法简单有效,适合四黄烧伤膏复方的提取,可以为四黄烧伤膏提取工艺优化提供参考。 展开更多
关键词 四黄烧伤膏 正交设计 主成分分析 指纹图谱 提取工艺
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A New Infeasible-Interior-Point Algorithm for Linear Programming over Symmetric Cones
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作者 chang-he liu You-lin SHANG Ping HAN 《Acta Mathematicae Applicatae Sinica》 SCIE CSCD 2017年第3期771-788,共18页
In this paper we present an infeasible-interior-point algorithm, based on a new wide neighbourhood N( t1, t2, η), for linear programming over symmetric cones. We treat the classical Newton direction as the sum of t... In this paper we present an infeasible-interior-point algorithm, based on a new wide neighbourhood N( t1, t2, η), for linear programming over symmetric cones. We treat the classical Newton direction as the sum of two other directions. We prove that if these two directions are equipped with different and appropriate step sizes, then the new algorithm has a polynomial convergence for the commutative class of search directions. In particular, the complexity bound is O(r1.5 log ε-1) for the Nesterov-Todd (NT) direction, and O(r2 log ε-1) for the xs and sx directions, where r is the rank of the associated Euclidean Jordan algebra and ε 〉 0 is the required precision. If starting with a feasible point (x0, y0, s0) in N(t1, t2, η), the complexity bound is O( √ r log ε-1) for the NT direction, and O(r log ε-1) for the xs and sx directions. When the NT search direction is used, we get the best complexity bound of wide neighborhood interior-point algorithm for linear programming over symmetric cones. 展开更多
关键词 symmetric cone Euclidean Jordan algebra interior-point methods linear programming polynomial complexity
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Polynomial Convergence of Primal-Dual Path-Following Algorithms for Symmetric Cone Programming Based on Wide Neighborhoods and a New Class of Directions
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作者 chang-he liu Yuan-Yuan Huang You-Lin Shang 《Journal of the Operations Research Society of China》 EI CSCD 2017年第3期333-346,共14页
This paper presents a class of primal-dual path-following interior-point algorithms for symmetric cone programming(SCP)based on wide neighborhoods and new directions with a parameterθ.When the parameterθ=1,the direc... This paper presents a class of primal-dual path-following interior-point algorithms for symmetric cone programming(SCP)based on wide neighborhoods and new directions with a parameterθ.When the parameterθ=1,the direction is exactly the classical Newton direction.When the parameterθis independent of the rank of the associated Euclidean Jordan algebra,the algorithm terminates in at most O(κr logε−1)iterations,which coincides with the best known iteration bound for the classical wide neighborhood algorithms.When the parameterθ=√n/βτand Nesterov–Todd search direction is used,the algorithm has O(√r logε−1)iteration complexity,the best iteration complexity obtained so far by any interior-point method for solving SCP.To our knowledge,this is the first time that a class of interior-point algorithms including the classical wide neighborhood path-following algorithm is proposed and analyzed over symmetric cone. 展开更多
关键词 Path-following interior-point algorithm Wide neighborhood Symmetric cone programming Euclidean Jordan algebra Polynomial complexity
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A New Infeasible-Interior-Point Algorithm Based on Wide Neighborhoods for Symmetric Cone Programming
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作者 chang-he liu Dan Wu You-Lin Shang 《Journal of the Operations Research Society of China》 EI CSCD 2016年第2期147-165,共19页
In this paper,we present an infeasible-interior-point algorithm,based on a new wide neighborhood for symmetric cone programming.We treat the classical Newton direction as the sum of two other directions,and equip them... In this paper,we present an infeasible-interior-point algorithm,based on a new wide neighborhood for symmetric cone programming.We treat the classical Newton direction as the sum of two other directions,and equip them with different step sizes.We prove the complexity bound of the new algorithm for the Nesterov-Todd(NT)direction,and the xs and sx directions.The complexity bounds obtained here are the same as small neighborhood infeasible-interior-point algorithms over symmetric cones. 展开更多
关键词 Infeasible-interior-point algorithm Wide neighborhood Symmetric cone programming Euclidean Jordan algebra Polynomial complexity
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Inexact Operator Splitting Method for Monotone Inclusion Problems
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作者 Yuan-Yuan Huang chang-he liu You-Lin Shang 《Journal of the Operations Research Society of China》 EI CSCD 2021年第2期273-306,共34页
The Douglas–Peaceman–Rachford–Varga operator splitting methods are a class ofefficient methods for finding a zero of the sum of two maximal monotone operatorsin a real Hilbert space;however, they are sometimes diff... The Douglas–Peaceman–Rachford–Varga operator splitting methods are a class ofefficient methods for finding a zero of the sum of two maximal monotone operatorsin a real Hilbert space;however, they are sometimes difficult or even impossible tosolve the subproblems exactly. In this paper, we suggest an inexact version in whichsome relative error criterion is discussed. The corresponding convergence propertiesare established, and some preliminary numerical experiments are reported to illustrateits efficiency. 展开更多
关键词 Monotone operator Splitting methods Convergence properties Error criterion
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A Feasible Decomposition Method for Constrained Equations and Its Application to Complementarity Problems
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作者 Xiang-li Li Hong-wei liu chang-he liu 《Acta Mathematicae Applicatae Sinica》 SCIE CSCD 2011年第3期535-548,共14页
关键词 convex quadratic programming nonnegative constraints feasible decomposition method
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