Bismuth selenide nanosheet layer materials with peroxidase activity for antimicrobial applications

A new type of bismuth selenide nanosheet layer material was synthesized by solvent thermal method,which is harmless to human body and can be used in combination with hydrogen peroxide solution as a new type of modern insecticide.The particle size of the bismuth selenide nanosheet material is about 80 nm,and it has good dispersion in water.In this experiment,the antibacterial ability of the material was investigated using Escherichia coli and Staphylococcus aureus as bacterial models and plant pathogens such as strawberry gray mold and tomato gray mold as fungal models.In addition,the in vivo bioassay indicated that Bi_(2)Se_(3)tH_(2)O_(2)possessed effective control against Pepper Anthrax Disease.The biocompatibility of this material was also investigated using human umbilical vein endothelial cells(HUVEC)as a model,and the results showed that the bismuth selenide nanosheet material has good antibacterial ability and biocompatibility.

Novel quinoxalinone-1,2,3-triazole derivatives as potential antifungal agents for plant anthrax disease:Design,synthesis,antifungal activity and SAR study

A series of quinoxalinone-1,2,3-triazole derivatives have been synthesized and tested for antifungal activity against phytopathogenic fungus through mycelial growth inhibition in vitro,spore germination inhibition in vitro and control effect in vivo.The results showed that the pharmacophore quinoxalinone and 1,2,3-triazole displayed promising antifungal activity.The EC50 value against C.gloeosporioides of 6a-1 was 1.17μg/mL and the compound 6c-1 showed the good bioactivity against C.fragariae Brooks and P.oryzae Cav.,displaying EC50 values of 5.56,4.62μg/mL,respectively.The inhibitory of spore germination by 6a-1 was performed with EC50 value of 1.91μg/mL.In addition,the in vivo bioassay indicated that 6a-1 possessed effective control against Pepper Anthrax Disease in protective treatment.For given activity data of target compounds,structure-activity relationship(SAR)study was operated,hoping for optimizing the target structure to find lead compound with higher activity.

Reducing pesticide use:Synthesis and application of ROS-SPC as an efficient nanocarrier and scavenger of reactive oxygen species in plants

There is an increasing need to reduce the use of pesticides to reduce their potential threat to food/environmental safety.At the same time,an increase in reactive oxygen species(ROS)induced by abiotic stresses in plants can lead to an increase in ROS in the plant and affect yield.In this paper,ROS-SPC was synthesised by two reactions and used as an efficient pesticide nanocarrier/adjuvant and scavenger of reactive oxygen species(ROS)in plants.By hydrophobic interaction,ROS-SPC spontaneously conjugated tofluazinam with a pesticide loading capacity(PLC)of 15.1%.Afterfluazinam was conjugated to ROS-SPC,the particle size offluazinam was reduced from 64.70 nm reduced to 19.82 nm,and the contact angle of pesticide droplets on plant leaves was significantly reduced from 59.44°to 26.76°.ROS-SPC as a carrier was tested to inhibit phytopathogenic fungi by 200%more than conventional delivery methods.In addition,we also learned that ROS-SPC with endocytosis capability can indeed remove reactive oxygen species from plants.Tests using HUVEC cells showed that ROS-SPC has low cytotoxicity within a reasonable range of applications,and ROS-SPC was tested to have low toxicity to pollinating bees.