Normal brain function requires continuous supply of oxygen and glucose in a strict manner.The close spatial and temporal relationship between neural activity and cerebral bloodflow(CBF)is termed as neurovascular coupli...Normal brain function requires continuous supply of oxygen and glucose in a strict manner.The close spatial and temporal relationship between neural activity and cerebral bloodflow(CBF)is termed as neurovascular coupling,which is dependent or not dependent on astrocytes.The increase inflow evoked by brain activity is mediated by the concerted action of multiple mediators that originate from different cells and act at different levels of the cerebral vasculature.More studies are needed for further understanding the precise mechanisms underlying neurovascular coupling,espe-cially the implications of astrocytes.展开更多
文摘Normal brain function requires continuous supply of oxygen and glucose in a strict manner.The close spatial and temporal relationship between neural activity and cerebral bloodflow(CBF)is termed as neurovascular coupling,which is dependent or not dependent on astrocytes.The increase inflow evoked by brain activity is mediated by the concerted action of multiple mediators that originate from different cells and act at different levels of the cerebral vasculature.More studies are needed for further understanding the precise mechanisms underlying neurovascular coupling,espe-cially the implications of astrocytes.
