Two new eudesmane-type sesquiterpenoid lactones,named chlorelactone A(1)and chlorelactone B(2),and one new labdane-type diterpenoid,named elatiorlabdane(3),along with seven known sesquiterpenoids and one known disesqu...Two new eudesmane-type sesquiterpenoid lactones,named chlorelactone A(1)and chlorelactone B(2),and one new labdane-type diterpenoid,named elatiorlabdane(3),along with seven known sesquiterpenoids and one known disesquiterpenoid were isolated from the whole plants of Chloranthus elatior.Their structures and relative configurations were established on the basis of extensive spectroscopic analysis.展开更多
Sixteen tropinone derivatives were prepared,and their antitumor activities against five human cancer cells(HL-60,A-549,SMMC-7721,MCF-7 and SW480)were evaluated with MTS[3-(4,5-dimethylthiazol-2-yl)-5-(3-carboxy methox...Sixteen tropinone derivatives were prepared,and their antitumor activities against five human cancer cells(HL-60,A-549,SMMC-7721,MCF-7 and SW480)were evaluated with MTS[3-(4,5-dimethylthiazol-2-yl)-5-(3-carboxy methoxyphenyl)-2-(4-sulfopheny)-2H-tetrazolium]assay.Most of the derivatives exhibited better activities compared with tropinone at the concentration of 40 pM.Particularly,derivative 6 showed significant activities with IC50 values of 3.39,13.59,6.65,13.09 and 12.38 pM respectively against HL-60,A-549,SMMC-7721,MCF-7 and SW480 cells,which suggested more potent activities than that of cis-dichlorodiamineplatinum(DDP).展开更多
基金supported by National Natural Science Funding of China(No.81072543)the Key Project of Knowledge Innovation Project of CAS(No.KSCX2-EW-Q-10)funds(No.P2009-KF04)from the State Key Laboratory of Phytochemistry and Plant Resources in West China.
文摘Two new eudesmane-type sesquiterpenoid lactones,named chlorelactone A(1)and chlorelactone B(2),and one new labdane-type diterpenoid,named elatiorlabdane(3),along with seven known sesquiterpenoids and one known disesquiterpenoid were isolated from the whole plants of Chloranthus elatior.Their structures and relative configurations were established on the basis of extensive spectroscopic analysis.
基金supported by the Hundred Talents Program of the Chinese Academy of Sciences(CAS),the Youth Innovation Promotion Association,CAS and the Program of Yunling Scholarship.
文摘Sixteen tropinone derivatives were prepared,and their antitumor activities against five human cancer cells(HL-60,A-549,SMMC-7721,MCF-7 and SW480)were evaluated with MTS[3-(4,5-dimethylthiazol-2-yl)-5-(3-carboxy methoxyphenyl)-2-(4-sulfopheny)-2H-tetrazolium]assay.Most of the derivatives exhibited better activities compared with tropinone at the concentration of 40 pM.Particularly,derivative 6 showed significant activities with IC50 values of 3.39,13.59,6.65,13.09 and 12.38 pM respectively against HL-60,A-549,SMMC-7721,MCF-7 and SW480 cells,which suggested more potent activities than that of cis-dichlorodiamineplatinum(DDP).
