The paraventricular nucleus of the hypothalamus(PVH)acts as a cohesive functional unit that regulates neuroendocrine and autonomic function,complex behavior,and negative emotions after stress.However,how the PVH integ...The paraventricular nucleus of the hypothalamus(PVH)acts as a cohesive functional unit that regulates neuroendocrine and autonomic function,complex behavior,and negative emotions after stress.However,how the PVH integrates arousal with these biological functions has only recently been explored.Clinical reports,combined with neurotoxic lesioning,immunochemistry,neuronal activity recordings,and the polysomnographic analyses of genetically modified animals,have revealed that the PVH is important for the control of wakefulness.Here,we review emerging anatomical and neural mechanisms for sleep–wake regulation in the PVH to support its essential role in the promotion and maintenance of wakefulness.展开更多
基金partly supported by the National Major Project of China Science and Technology Innovation 2030 for Brain Science and BrainInspired Technology(Grant No.2021ZD0203400 to Z.-L.H.)the National Natural Science Foundation of China(Grant Nos.82020108014 and 32070984 to Z.-L.H.)+3 种基金the Shanghai Science and Technology Innovation Action Plan Laboratory Animal Research Project(Grant No.201409001800 to Z.-L.H.)Program for Shanghai Outstanding Academic Leaders(to Z.-L.H.)the Shanghai Municipal Science and Technology Major ProjectZJLab(Grant No.2018SHZDZX01 to Z-.L.H.)。
文摘The paraventricular nucleus of the hypothalamus(PVH)acts as a cohesive functional unit that regulates neuroendocrine and autonomic function,complex behavior,and negative emotions after stress.However,how the PVH integrates arousal with these biological functions has only recently been explored.Clinical reports,combined with neurotoxic lesioning,immunochemistry,neuronal activity recordings,and the polysomnographic analyses of genetically modified animals,have revealed that the PVH is important for the control of wakefulness.Here,we review emerging anatomical and neural mechanisms for sleep–wake regulation in the PVH to support its essential role in the promotion and maintenance of wakefulness.
