Ypsiyunnosides A-E,Five New Cholestanol Glycosides from Ypsilandra yunnanensis

Phytochemicalinvestigation onthe whole plants of Ypsilandra yunnanensiswas carried out forthe firsttime andledtothe isolation of five new cholestanol glycosides,ypsiyunnosides A–E(1–5),and one known analogue.Their structures were determined mainly by detailed spectroscopic analysis,including extensive 1D and 2D NMR,MS and UV,as well as chemical methods.Among them,compound 1 possessed a rare 6/6/6/5/5 fused-rings cholestanol sketelon,which was identified as(23R,25R)-3β,16α,26-triol-16,23-cyclocholest-5,17(20)-dien-22-one.Their induced platelet aggregation activities and cytotoxicities were evaluated.Graphical Abstract Five new cholestanol glycosides,ypsiyunnosides A–E(1–5),were isolated from the whole plants of Ypsilandra yunnanensis.Compound 1 possessed a rare 6/6/6/5/5 fused-rings cholestanol sketelon.Their structures were elucidated by a combination of 1D and 2D NMR,MS and chemical analysis.

Steroidal and pregnane glycosides from Ypsilandra thibetica

The whole plants of Ypsilandra thibetica have been analyzed as part of a systematic study on saponin constituents of medicinal plants.This has resulted in the isolation of two new bisdesmosidic furostanol saponins,named ypsilandroside P(1)and ypsilandroside Q(2),and one new pregnane glycoside,named ypsilandroside R(3),together with nine known steroidal glycosides.Their structures were elucidated on the basis of extensive spectroscopic analysis,including that of 2D NMR data,and the results of acidic hydrolysis.Ypsilandroside P(1)was cytotoxicity against two human tumor cell lines.

Untiring Researches for Alternative Resources of Rhizoma Paridis

Rhizoma Paridis(RP,M®),a traditional Chinese medicine,is the rhizoma of Paris polyphylla var.yunnanensis(PPY)or P.polyphylla var.chinensis which are widely used as important raw materials for several Chinese patent drugs.However,the wild resources of these herbs have become less and less due to their slow-growing characteristics and previously excessive excavation.This review covers untiring investigations on alternative resources of RP by our research group over the past decades,including non-medicinal parts of PPY as well as other plants of Liliaceae and Liliflorae families.The arial parts of PPY and the whole plants of Trillium kamtschaticum might be alternative resources for RP based on the fact that they shared the same or similar saponins and bioactivities.

Effect of visual training on cognitive function in stroke patients

Objective:To observe the effect of visual training on cognitive function in stoke patients.Methods:Eighty stroke patients with cognitive dysfunction were divided into two groups(n?40 in each group).The control group received conventional rehabilitation therapies.The experimental group received visual training in addition to the conventional therapies.This training was administered for 30 min once a day,five times a week,for four weeks.All patients were screened with the Montreal Cognitive Assessment(MoCA)both before and after the four weeks of intervention.Results:After the four-week intervention,patients in the experimental group increased their scores for attention and concentration,executive function,memory,visual skills,abstract thinking,calculation,and directional force,as well as their total standard score(p<0.01).The patients in the control group also increased their scores in the executive function,visual skills and abstract thinking,as well as their total standard score(p<0.05).However,the experimental group scored higher than the control group for both the individual and total standard scores(p<0.05).Conclusion:Visual training could improve cognitive function of patients with stroke.

The correlation between socioeconomic status and health self-management in the elderly

Purpose:To determine the correlation between socioeconomic status and health selfmanagement in the elderly and to provide a scientific basis for the promotion of healthy ageing.Methods:We recruited 6173 people aged
60 years from three regions in Hebei Province using the multi-stage stratified cluster sampling method.The participants were surveyed using questionnaires.Results:The health self-management behaviours of elderly people differed with the area of residence,education level,and personal monthly income.An ordered probit model showed that behaviours were better in elderly people who lived in urban areas,who were educated to college level or higher,and with higher monthly incomes(p<0.05).Conclusion:Socioeconomic status plays a decisive role in health self-management in the elderly.We suggest appropriate measures for promoting health self-management among the elderly.