We proposed a periodic mid-infrared broadband chiral structure. Its unit cell consists of four indium tin oxide(ITO) helix subunits with different radii. The simulation results show that the flat-topped broadband circ...We proposed a periodic mid-infrared broadband chiral structure. Its unit cell consists of four indium tin oxide(ITO) helix subunits with different radii. The simulation results show that the flat-topped broadband circular dichroism(CD) can be achieved in the mid-infrared band by optimizing the parameters of helix structures. The simulation results also show that compared with the metallic(Ag and Au) helix structures, the ITO helix structure proposed exhibits evidently better broadband CD and optical activity, which provides a new idea for the design of broadband polarization state control devices in the mid-infrared band.展开更多
Highly sensitive and reliable detection of multiple myeloma remains a major challenge in liquid biopsy. Herein, for the first time, quantum dot-molecular beacon (QD-MB) functionalized MoS_(2) (QD-MB @MoS_(2)) fluoresc...Highly sensitive and reliable detection of multiple myeloma remains a major challenge in liquid biopsy. Herein, for the first time, quantum dot-molecular beacon (QD-MB) functionalized MoS_(2) (QD-MB @MoS_(2)) fluorescent probes were designed for the dual detection of multiple myeloma (MM)-related miRNA-155 and miRNA-150. The results indicate that the two probes can effectively detect miRNA-155 and miRNA-150 simultaneously with satisfactory recovery rates, and the limit of detections (LODs) of miRNA-155 and miRNA-150 in human serum are low to 7.19 fM and 5.84 fM, respectively. These results indicate that our method is the most sensitive detection so far reported and that the designed fluorescent probes with signal amplification strategies can achieve highly sensitive detection of MM-related miRNAs for MM diagnosis.展开更多
We studied Goos–H？nchen（GH） shifts on a reflective phase-gradient-produced metasurface. Their analytical solutions were achieved for both TE and TM polarizations utilizing the generalized Snell＇s law. The calcula...We studied Goos–H？nchen（GH） shifts on a reflective phase-gradient-produced metasurface. Their analytical solutions were achieved for both TE and TM polarizations utilizing the generalized Snell＇s law. The calculated results show that the GH shifts are evidently affected by phase gradients and incident angles, which means that a certain range of GH shifts can be realized as long as an incident angle, phase gradient, and frequency are properly chosen. This offers an effective method for the control of GH shifts.展开更多
基金This work was supported by the National Natural Science Foundation of China(Nos.61771227 and 62071208)the Priority Academic Program Development of Jiangsu Higher Education Institutions(PAPD)。
文摘We proposed a periodic mid-infrared broadband chiral structure. Its unit cell consists of four indium tin oxide(ITO) helix subunits with different radii. The simulation results show that the flat-topped broadband circular dichroism(CD) can be achieved in the mid-infrared band by optimizing the parameters of helix structures. The simulation results also show that compared with the metallic(Ag and Au) helix structures, the ITO helix structure proposed exhibits evidently better broadband CD and optical activity, which provides a new idea for the design of broadband polarization state control devices in the mid-infrared band.
基金The authors acknowledge the generous financial support from the National Natural Science Foundation of China(61971207,61975070,51902143,61775088)Priority Academic Program Development of Jiangsu Higher Education Institutions(PAPD),Key Research and Development Project of Jiangsu Province(BE2018062,BE2019033)+6 种基金Natural Science Foundation of Jiangsu Province(BK20191467)Post-graduate Research&Practice Innovation Program of Jiangsu Province(KYCX20_2229)International S&T Cooperation Program of Jiangsu Province(BZ2019063,BZ2020045,BZ2020030)Natural Science Foundation of the Jiangsu Higher Education Institutes of China(19KJB430018,20KJA430003)Special Project for Technology Innovation of Xuzhou City(KC19250,KC20201,KC20244)Open Project of State Key Laboratory of Advanced Materials and Electronic Components(FHR-JS-202011017)We also thank Dr.Zhiling Yan for his help and support on the collection of blood samples.WC would like to thank the support from Solgro Inc.,Guangxi Jialouyuan Medical Inc.and UT Arlington distinguished award.
文摘Highly sensitive and reliable detection of multiple myeloma remains a major challenge in liquid biopsy. Herein, for the first time, quantum dot-molecular beacon (QD-MB) functionalized MoS_(2) (QD-MB @MoS_(2)) fluorescent probes were designed for the dual detection of multiple myeloma (MM)-related miRNA-155 and miRNA-150. The results indicate that the two probes can effectively detect miRNA-155 and miRNA-150 simultaneously with satisfactory recovery rates, and the limit of detections (LODs) of miRNA-155 and miRNA-150 in human serum are low to 7.19 fM and 5.84 fM, respectively. These results indicate that our method is the most sensitive detection so far reported and that the designed fluorescent probes with signal amplification strategies can achieve highly sensitive detection of MM-related miRNAs for MM diagnosis.
基金supported by the National Natural Science Foundation of China(Nos.11674132,61771227,61575087,and 11704162)the Natural Science Foundation(No.BK20151164)the Priority Academic Program Development of Jiangsu Higher Education Institutions(PAPD)of Jiangsu Province
文摘We studied Goos–H？nchen（GH） shifts on a reflective phase-gradient-produced metasurface. Their analytical solutions were achieved for both TE and TM polarizations utilizing the generalized Snell＇s law. The calculated results show that the GH shifts are evidently affected by phase gradients and incident angles, which means that a certain range of GH shifts can be realized as long as an incident angle, phase gradient, and frequency are properly chosen. This offers an effective method for the control of GH shifts.
