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免疫及靶向药物联合肝动脉灌注化疗治疗晚期肝癌的回顾性分析 被引量:11
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作者 刘东明 穆瀚 +3 位作者 刘长富 邢文阁 宋天强 李慧锴 《中国肿瘤临床》 CAS CSCD 北大核心 2023年第17期888-892,共5页
目的:探讨免疫及靶向药物联合肝动脉灌注化疗术(hepatic arterial infusion chemotherapy,HAIC)治疗晚期肝细胞癌(hepatocellular carcinoma,HCC)的疗效与安全性。方法:回顾性分析2021年4月至2022年4月天津医科大学肿瘤医院收治的34例行... 目的:探讨免疫及靶向药物联合肝动脉灌注化疗术(hepatic arterial infusion chemotherapy,HAIC)治疗晚期肝细胞癌(hepatocellular carcinoma,HCC)的疗效与安全性。方法:回顾性分析2021年4月至2022年4月天津医科大学肿瘤医院收治的34例行HAIC联合信迪利单抗及贝伐珠单抗生物类似物治疗的晚期HCC患者,以首次治疗为起点,以患者死亡、疾病进展及不可耐受的不良反应为终点,按照实体肿瘤的疗效评价(mRECIST)1.1标准进行疗效评估,随访截至2023年4月。主要研究终点为客观缓解率(objective response rate,ORR),次要研究终点为疾病控制率(disease control rate,DCR)、总生存期(overall survival,OS)、无复发生存期(disease-free survival,DFS)、手术转化率及安全性。结果:ORR为52.9%,DCR可达到85.3%,手术转化利率为41.1%。部分缓解(partial response,PR)组1年OS及DFS分别为94.4%、50.0%;病变稳定(stable disease,SD)+病变进展(progressive disease,PD)组患者1年OS及DFS分别为66.7%、25.0%,两组差距均有统计学意义(P=0.002及P=0.013)。常见的不良反应有恶心呕吐(38.2%)、高血压(32.4%)及血小板减少(29.4%)等,无治疗相关死亡事件发生。结论:HAIC联合信迪利单抗及贝伐珠单抗生物类似物治疗晚期HCC的客观缓解率高,安全性良好,为后续临床试验的开展奠定了基础。 展开更多
关键词 晚期肝癌 肝动脉灌注化疗 免疫治疗 靶向治疗 不良反应
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Using machine learning algorithms to estimate stand volume growth of Larix and Quercus forests based on national-scale Forest Inventory data in China 被引量:2
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作者 Huiling Tian Jianhua Zhu +8 位作者 Xiao He Xinyun Chen Zunji Jian Chenyu Li Qiangxin Ou Qi Li Guosheng Huang changfu liu Wenfa Xiao 《Forest Ecosystems》 SCIE CSCD 2022年第3期396-406,共11页
Estimating the volume growth of forest ecosystems accurately is important for understanding carbon sequestration and achieving carbon neutrality goals.However,the key environmental factors affecting volume growth diff... Estimating the volume growth of forest ecosystems accurately is important for understanding carbon sequestration and achieving carbon neutrality goals.However,the key environmental factors affecting volume growth differ across various scales and plant functional types.This study was,therefore,conducted to estimate the volume growth of Larix and Quercus forests based on national-scale forestry inventory data in China and its influencing factors using random forest algorithms.The results showed that the model performances of volume growth in natural forests(R^(2)=0.65 for Larix and 0.66 for Quercus,respectively)were better than those in planted forests(R^(2)=0.44 for Larix and 0.40 for Quercus,respectively).In both natural and planted forests,the stand age showed a strong relative importance for volume growth(8.6%–66.2%),while the edaphic and climatic variables had a limited relative importance(<6.0%).The relationship between stand age and volume growth was unimodal in natural forests and linear increase in planted Quercus forests.And the specific locations(i.e.,altitude and aspect)of sampling plots exhibited high relative importance for volume growth in planted forests(4.1%–18.2%).Altitude positively affected volume growth in planted Larix forests but controlled volume growth negatively in planted Quercus forests.Similarly,the effects of other environmental factors on volume growth also differed in both stand origins(planted versus natural)and plant functional types(Larix versus Quercus).These results highlighted that the stand age was the most important predictor for volume growth and there were diverse effects of environmental factors on volume growth among stand origins and plant functional types.Our findings will provide a good framework for site-specific recommendations regarding the management practices necessary to maintain the volume growth in China's forest ecosystems. 展开更多
关键词 Stand volume growth Stand origin Plant functional type National forest inventory data Random forest algorithms
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On-line Chatter Detection Using an Improved Support Vector Machine 被引量:1
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作者 changfu liu Wenxiang ZHANG 《Instrumentation》 2019年第2期2-7,共6页
On-line chatter detection can avoid unstable cutting through monitoring the machining process.In order to identify chatter in a timely manner,an improved Support Vector Machine(SVM)is developed in this paper,based on ... On-line chatter detection can avoid unstable cutting through monitoring the machining process.In order to identify chatter in a timely manner,an improved Support Vector Machine(SVM)is developed in this paper,based on extracted features.In the SVM model,the penalty factor(e)and the core parameter(g)have important influence on the classification,more than from Kernel Functions(KFs).Hence,first the classification results are conducted using different KFs.Then two methods are presented for exploring the best parameters.The chatter identification results show that the Genetic Algorithm(GA)approach is more suitable for deciding the parameters than the Grid Explore(GE)approach. 展开更多
关键词 ON-LINE Chatter DETECTION Support VECTOR MACHINE PARAMETER Optimization GENETIC Algorithms
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