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Electrochemical and biological performance of hierarchical platinum-iridium electrodes structured by a femtosecond laser 被引量:1
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作者 Linze Li Changqing Jiang +5 位作者 Wanru Duan Zhiyan Wang Feng Zhang changgeng he Tiangang Long Luming Li 《Microsystems & Nanoengineering》 SCIE EI CSCD 2022年第5期161-170,共10页
Neural electrode interfaces are essential to the stimulation safety and recording quality of various bioelectronic therapies.The recently proposed hierarchical platinum-iridium(Pt-Ir)electrodes produced by femtosecond... Neural electrode interfaces are essential to the stimulation safety and recording quality of various bioelectronic therapies.The recently proposed hierarchical platinum-iridium(Pt-Ir)electrodes produced by femtosecond lasers have exhibited superior electrochemical performance in vitro,but their in vivo performance is still unclear.In this study,we explored the electrochemical performance,biological response,and tissue adhesion of hierarchical Pt-Ir electrodes by implantation in adult rat brains for 1,8,and 16 weeks.Regular smooth Pt-Ir electrodes were used as a control.The results showed that the electrochemical performance of both electrodes decreased and leveled off during implantation.However,after 16 weeks,the charge storage capacity of hierarchical electrodes stabilized at~16.8 mC/cm^(2),which was 15 times that of the smooth control electrodes(1.1 mC/cm^(2)).Moreover,the highly structured electrodes had lower impedance amplitude and cutoff frequency values.The similar histological response to smooth electrodes indicated good biocompatibility of the hierarchically structured Pt-Ir electrodes.Given their superior in vivo performance,the femtosecond laser-treated Pt-Ir electrode showed great potential for neuromodulation applications. 展开更多
关键词 PLATINUM PERFORMANCE electrode
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