The complement system plays a key role in the pathogenesis of autoimmune diseases,which usually injures the kidney.More and more studies have shown the pathogenic role and indicated that abnormal activation of the com...The complement system plays a key role in the pathogenesis of autoimmune diseases,which usually injures the kidney.More and more studies have shown the pathogenic role and indicated that abnormal activation of the complement system was highly involved in the outbreak of autoimmune diseases.This review mainly introduced recent studies of complement system activation contributing to the pathogenesis of autoimmune diseases,including systemic lupus erythematosus,antiphospholipid syndrome,antineutrophil cytoplasmic antibody-associated vasculitides,and so on.Understanding the pathogenic roles of complement activation in various autoimmune diseases will identify potential novel therapeutic targets on complement systems.展开更多
基金National Natural Science Foundation of China(Grant/Award Number:81870479)Beijing Natural Science Foundation(Grant/Award Number:7192207)Chinese Academy of Medical Sciences Research(Grant/Award Number:2019RU023)。
文摘The complement system plays a key role in the pathogenesis of autoimmune diseases,which usually injures the kidney.More and more studies have shown the pathogenic role and indicated that abnormal activation of the complement system was highly involved in the outbreak of autoimmune diseases.This review mainly introduced recent studies of complement system activation contributing to the pathogenesis of autoimmune diseases,including systemic lupus erythematosus,antiphospholipid syndrome,antineutrophil cytoplasmic antibody-associated vasculitides,and so on.Understanding the pathogenic roles of complement activation in various autoimmune diseases will identify potential novel therapeutic targets on complement systems.
