Wnt/β-catenin signaling has been broadly implicated in human cancers and experimental cancer models of animals.Aberrant activation of Wnt/β-catenin signaling is tightly linked with the increment of prevalence,advanc...Wnt/β-catenin signaling has been broadly implicated in human cancers and experimental cancer models of animals.Aberrant activation of Wnt/β-catenin signaling is tightly linked with the increment of prevalence,advancement of malignant progression,development of poor prognostics,and even ascendence of the cancer-associated mortality.Early experimental investigations have proposed the theoretical potential that efficient repression of this signaling might provide promising therapeutic choices in managing various types of cancers.Up to date,many therapies targeting Wnt/β-catenin signaling in cancers have been developed,which is assumed to endow clinicians with new opportunities of developing more satisfactory and precise remedies for cancer patients with aberrant Wnt/β-catenin signaling.展开更多
Seizures or epilepsy is one of the common serious complications in patients with advanced human immunodeficiency virus(HIV)infection or diagnosed with immune deficiency syndrome,with higher incidence and prevalence th...Seizures or epilepsy is one of the common serious complications in patients with advanced human immunodeficiency virus(HIV)infection or diagnosed with immune deficiency syndrome,with higher incidence and prevalence than in the general population.Generalized seizures are the most common type in the patients.Opportunistic infections are a stereotypical predisposing factor for seizures in HIV patients,but a variety of pathogenic factors can also be found in these patients,such as metabolic perturbation and drug-drug interactions.The diagnostic criteria for seizures in these patients are the same as those in the general population.As HIV patients with seizures need to take both antivirals and antiepileptic drugs,the risk of drug-drug interactions is greatly increased,and the side effects of drugs may also become more prominent.At present,most experience in antiepileptic drug usage has come from the general population,and there is still a lack of guidance of antiepileptic drug use in special groups such as the HIV-infected people.Unlike the old-generation drugs that involve metabolisms through CYP450,the first-line antiepileptic drugs usually bypass CYP450,thus having less drug-drug interactions.In this review,we summarize the recent research progress on the above-mentioned widely discussed topics and make a prospect on future research direction.展开更多
基金The work is supported by the National Natural Science Foundation of China 81825005State Key Laboratory of Oral Diseases SKLOD202007(L.Y.).
文摘Wnt/β-catenin signaling has been broadly implicated in human cancers and experimental cancer models of animals.Aberrant activation of Wnt/β-catenin signaling is tightly linked with the increment of prevalence,advancement of malignant progression,development of poor prognostics,and even ascendence of the cancer-associated mortality.Early experimental investigations have proposed the theoretical potential that efficient repression of this signaling might provide promising therapeutic choices in managing various types of cancers.Up to date,many therapies targeting Wnt/β-catenin signaling in cancers have been developed,which is assumed to endow clinicians with new opportunities of developing more satisfactory and precise remedies for cancer patients with aberrant Wnt/β-catenin signaling.
基金West China Hospital 135 Talent ExcellenceDevelopment Project(NO.ZYGD20011)Sichuan University PostdoctoralInterdisciplinary Innovation Startup Foundation,and Science and TechnologyActivities for overseas Returnees in Sichuan Province in 2020.
文摘Seizures or epilepsy is one of the common serious complications in patients with advanced human immunodeficiency virus(HIV)infection or diagnosed with immune deficiency syndrome,with higher incidence and prevalence than in the general population.Generalized seizures are the most common type in the patients.Opportunistic infections are a stereotypical predisposing factor for seizures in HIV patients,but a variety of pathogenic factors can also be found in these patients,such as metabolic perturbation and drug-drug interactions.The diagnostic criteria for seizures in these patients are the same as those in the general population.As HIV patients with seizures need to take both antivirals and antiepileptic drugs,the risk of drug-drug interactions is greatly increased,and the side effects of drugs may also become more prominent.At present,most experience in antiepileptic drug usage has come from the general population,and there is still a lack of guidance of antiepileptic drug use in special groups such as the HIV-infected people.Unlike the old-generation drugs that involve metabolisms through CYP450,the first-line antiepileptic drugs usually bypass CYP450,thus having less drug-drug interactions.In this review,we summarize the recent research progress on the above-mentioned widely discussed topics and make a prospect on future research direction.
