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Optimization of dewatering schemes for a deep foundation pit near the Yangtze River, China 被引量:3
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作者 yang You changhong yan +2 位作者 Baotian Xu Shi Liu Canhui Che 《Journal of Rock Mechanics and Geotechnical Engineering》 CSCD 2018年第3期555-566,共12页
A deep foundation pit constructed for an underground transportation hub was excavated near the Yangtze River. Among the strata, there are two confined aquifers, between which lies an aquiclude that is partially missin... A deep foundation pit constructed for an underground transportation hub was excavated near the Yangtze River. Among the strata, there are two confined aquifers, between which lies an aquiclude that is partially missing. To guarantee the safety of pit excavation, the piezometric head of the upper confined aquifer, where the pit bottom is located, should be 1 m below the pit bottom, while that of the lower confined aquifer should be dewatered down to a safe water level to avoid uplift problem. The Yangtze River levee is notably close to the pit, and its deformation caused by dewatering should be controlled. A pumping test was performed to obtain the hydraulic conductivity of the upper confined aquifer. The average value of the hydraulic conductivity obtained from analytical calculation is 20.45 m/d, which is larger than the values from numerical simulation(horizontal hydraulic conductivity K_H = 16 m/d and vertical hydraulic conductivity K_V = S m/d). The difference between K_H and K_V indicates the anisotropy of the aquifer. Two dewatering schemes were designed for the construction and simulated by the numerical models for comparison purposes. The results show that though the first scheme could meet the dewatering requirements, the largest accumulated settlement and differential settlement would be94.64 mm and 3.3‰, respectively, greatly exceeding the limited values. Meanwhile, the second scheme,in which the bottoms of the waterproof curtains in ramp B and the river side of ramp A are installed at a deeper elevation of-28 m above sea level, and 27 recharge wells are set along the levee, can control the deformation of the levee significantly. 展开更多
关键词 Deep foundation pit Parameter calculation Dewatering schemes Numerical simulation
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Experimental Study on the Compressive Strength of Concrete with Different Wheat Straw Treatment Techniques
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作者 Liang Wen changhong yan +3 位作者 Yehui Shi Zhenxiang Wang Gang Liu Wei Shi 《Journal of Renewable Materials》 EI 2023年第10期3681-3692,共12页
The treatment of wheat straw is very difficult,and its utilization rate is very low;accumulation causes air pollution and even fire.To make full use of wheat straw resources,we examined how using different physical an... The treatment of wheat straw is very difficult,and its utilization rate is very low;accumulation causes air pollution and even fire.To make full use of wheat straw resources,we examined how using different physical and chemical methods to treat the wheat straw which can improve its strength abilities,or enhance the activity of wheat straw ash.In terms of concrete additives,it can reduce the amount of cement used.In this paper,we found that alkali treatment can significantly improve the tensile strength of wheat straw fiber,but polyvinyl alcohol treatment has no obvious effect on the strength of wheat straw fiber after alkali treatment.At the same time,we analyzed the wheat straw fiber microstructure through scanning electron microscopy,and we also studied the wheat straw ash chemical composition after 600℃ high-temperature treatment.Through the compressive strength test,we found that the strength of concrete decreases with increasing of wheat straw fiber and wheat straw powder content,and the compressive strength of concrete with wheat straw ash instead of 5%cement decreases little,and the strength of the concrete also decreases with the increasing of wheat straw ash.Through the macroscopic observation of the failure form of concrete,we found that the failure form of concrete with wheat straw ash is similar to that of common concrete,while the failure degree of concrete with wheat straw fiber and wheat straw powder is weakened.Through the scanning electron microscope test of the concrete,it was found that wheat straw fiber has an effect on the cracking of concrete and the inner compactness of concrete can also be affected by adding wheat straw ash and wheat straw powder. 展开更多
关键词 Wheat straw ash tensile strength scanning electron microscope compressive strength CONCRETE
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玉屏风散治疗慢性肾小球肾炎的临床疗效评价及作用机制研究
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作者 李雅静 白雅雯 +5 位作者 杜宇 严长宏 麻春杰 孙丽宁 卜凤跃 严昊阳 《Journal of Chinese Pharmaceutical Sciences》 CAS CSCD 2023年第12期1006-1026,共21页
本研究通过meta分析评价玉屏风散(YPF)治疗慢性肾小球肾炎(CGN)的临床疗效,并利用网络药理学和分子对接探讨其作用机制。检索国内外数据库CNKI、维普、中国生物医学、万方、PubMed和Cochrane建库至2023年5月YPF治疗CGN临床随机对照试验... 本研究通过meta分析评价玉屏风散(YPF)治疗慢性肾小球肾炎(CGN)的临床疗效,并利用网络药理学和分子对接探讨其作用机制。检索国内外数据库CNKI、维普、中国生物医学、万方、PubMed和Cochrane建库至2023年5月YPF治疗CGN临床随机对照试验,根据纳入和排除标准,纳入研究。运用RevMan5.4软件进行质量评估和meta分析,使用TSABeta软件对主要结局指标进行序贯分析。通过TCMSP、GeneC ards、OMIM、TTD数据库检索YPF的有效成分及CGN靶点,利用Venny2.1.0获取两者交集靶点,运用DAVID数据库进行GO和KEGG富集分析。通过AutoDockVina1.5.6软件进行分子对接。共纳入14项研究,1072名患者。meta分析结果显示,YPF在治疗CGN的临床总有效率[OR=6.99,95%CI(4.68,10.44)],证候改善率[OR=3.16,95%CI(1.43,6.98)],降低24小时尿蛋白[SMD=–1.90,95%CI(–2.54,–1.25)]、血清肌酐[SMD=–0.38,95%CI(–0.57,–0.19)],尿素氮[SMD=–0.46,95%CI(–0.63,–0.30)],均具有统计学意义(P<0.05)。序贯分析结果表明,本次meta结果是可靠的,YPF治疗CGN的总有效率优于单纯西药治疗。网络药理学共筛选出槲皮素、山奈酚、汉黄芩素等45种有效成分,关键靶点有TNF、AKT1、IL-6和VEGF等,涉及AGE-RAGE、TNF、PI3K-AKT等信号通路。分子对接显示,槲皮素、山奈酚、汉黄芩素等与关键靶点可稳定结合,结合能均≤–6.0 kJ/mol。结果发现,YPF对CGN是一种积极的治疗措施,其作用机制可能与多种成分、多个靶点、多条信号通路产生的免疫调节、抗炎、抗氧化和抗纤维化有关。 展开更多
关键词 玉屏风散 慢性肾小球肾炎 Meta分析 TSA 网络药理学 分子对接
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