In a high relative humidity(RH)environment,it is challenging for ethanol sensors to maintain a high response and excellent selectivity.Herein,tetragonal rutile SnO_(2)nanosheets decorated with NiO nanoparticles were s...In a high relative humidity(RH)environment,it is challenging for ethanol sensors to maintain a high response and excellent selectivity.Herein,tetragonal rutile SnO_(2)nanosheets decorated with NiO nanoparticles were synthesized by a two-step hydrothermal process.The NiO-decorated SnO_(2)nanosheet-based sensors displayed a significantly improved sensitivity and excellent selectivity to ethanol gas.For example,the 3 mol%NiO-decorated SnO_(2)(SnO_(2)-3Ni)sensor reached its highest response(153 at 100 ppm)at an operating temperature of 260℃.Moreover,the SnO_(2)-3Ni sensor had substantially improved moisture resistance.The excellent properties of the sensors can be attributed to the uniform dispersion of the NiO nanoparticles on the surface of the SnO_(2)nanosheets and the formation of NiO-SnO_(2)p–n heterojunctions.Considering the long-term stability and reproducibility of these sensors,our study suggests that the NiO nanoparticle-decorated SnO_(2)nanosheets are a promising material for highly efficient detection of ethanol.展开更多
Exhaled acetone is one of the representative biomarkers for the noninvasive diagnosis of type-1 diabetes.In this work,we have applied a facile two-step chemical bath deposition method for acetone sensors based onα-Fe...Exhaled acetone is one of the representative biomarkers for the noninvasive diagnosis of type-1 diabetes.In this work,we have applied a facile two-step chemical bath deposition method for acetone sensors based onα-Fe_(2)O_(3)/SnO_(2) hybrid nanoarrays(HNAs),where one-dimensional(1D)FeOOH nanorods are in situ grown on the prefabricated 2D SnO_(2) nanosheets for on-chip construction of 1D/2D HNAs.After annealing in air,ultrafineα-Fe_(2)O_(3) nanorods are homogenously distributed on the surface of SnO_(2) nanosheet arrays(NSAs).Gas sensing results show that theα-Fe_(2)O_(3)/SnO_(2) HNAs exhibit a greatly enhanced response to acetone(3.25 at 0.4 ppm)at a sub-ppm level compared with those based on pure SnO_(2) NSAs(1.16 at 0.4 ppm)and pureα-Fe_(2)O_(3) nanorods(1.03 at 0.4 ppm),at an operating temperature of 340℃.The enhanced acetone sensing performance may be attributed to the formation ofα-Fe_(2)O_(3)-SnO_(2) n-n heterostructure with 1D/2D hybrid architectures.Moreover,theα-Fe_(2)O_(3)/SnO_(2) HNAs also possess good reproducibility and selectivity toward acetone vapor,suggesting its potential application in breath acetone analysis.展开更多
Lactoferrin(LF)shows good anticancer biological activity.Lactoferrin can combine with chlorogenic acid(CGA)in dairy drinks like milk coffee and milk tea.However,the nature and functional changes of LF after binding of...Lactoferrin(LF)shows good anticancer biological activity.Lactoferrin can combine with chlorogenic acid(CGA)in dairy drinks like milk coffee and milk tea.However,the nature and functional changes of LF after binding of CGA are not clear.The stability and binding properties of CGA on LF and its antiproliferative effect on colorectal cancer SW480 cells were investigated by spectroscopic and cell experiments.The results showed that CGA could stabilize LF solution by reducing particle size(below 90 nm)and increasing zeta potential(over 14 in the absolute value).With addition of CGA,the UV absorption peak of LF solution changed(from 287 nm shifted to 290 nm)and fluorescence quenching occurred at the same time.By molecular dynamics calculation,the binding site number of CGA to LF was between 2 and 3 sites.Negative Gibbs free energy of(△G=-25.75±0.84)indicated that the interaction between LF and CGA can occur spontaneously and effectively.Cell viability and apoptosis test showed that CGA and LF inhibited the growth of colorectal cancer SW480 cells in a synergistic way.Most of cells were arrested at G0/G1 phase by the CGA-LF complex.We conclude that CGA can bind to LF to form a relatively stable complex under natural conditions,which increases their antiproliferative function on colorectal cancer cells.展开更多
基金This work was supported in part by the Shenzhen Science and Technology Innovation Committee under Grants JCYJ20170412154426330in part by the Guangdong Natural Science Funds under Grants 2016A030306042 and 2018A050506001in part by the Guangdong Special Support Program under Grant 2015TQ01X555.
文摘In a high relative humidity(RH)environment,it is challenging for ethanol sensors to maintain a high response and excellent selectivity.Herein,tetragonal rutile SnO_(2)nanosheets decorated with NiO nanoparticles were synthesized by a two-step hydrothermal process.The NiO-decorated SnO_(2)nanosheet-based sensors displayed a significantly improved sensitivity and excellent selectivity to ethanol gas.For example,the 3 mol%NiO-decorated SnO_(2)(SnO_(2)-3Ni)sensor reached its highest response(153 at 100 ppm)at an operating temperature of 260℃.Moreover,the SnO_(2)-3Ni sensor had substantially improved moisture resistance.The excellent properties of the sensors can be attributed to the uniform dispersion of the NiO nanoparticles on the surface of the SnO_(2)nanosheets and the formation of NiO-SnO_(2)p–n heterojunctions.Considering the long-term stability and reproducibility of these sensors,our study suggests that the NiO nanoparticle-decorated SnO_(2)nanosheets are a promising material for highly efficient detection of ethanol.
基金This work was supported in part by the Shenzhen Science and Technology Innovation Committee under Grant JCYJ20170412154426330the Foundation for Distinguished Young Talents in Higher Edu-cation of Guangdong,China,under Grant 2018KQNX226Guangdong Natural Science Funds under Grants 2016A030306042 and 2018A050506001。
文摘Exhaled acetone is one of the representative biomarkers for the noninvasive diagnosis of type-1 diabetes.In this work,we have applied a facile two-step chemical bath deposition method for acetone sensors based onα-Fe_(2)O_(3)/SnO_(2) hybrid nanoarrays(HNAs),where one-dimensional(1D)FeOOH nanorods are in situ grown on the prefabricated 2D SnO_(2) nanosheets for on-chip construction of 1D/2D HNAs.After annealing in air,ultrafineα-Fe_(2)O_(3) nanorods are homogenously distributed on the surface of SnO_(2) nanosheet arrays(NSAs).Gas sensing results show that theα-Fe_(2)O_(3)/SnO_(2) HNAs exhibit a greatly enhanced response to acetone(3.25 at 0.4 ppm)at a sub-ppm level compared with those based on pure SnO_(2) NSAs(1.16 at 0.4 ppm)and pureα-Fe_(2)O_(3) nanorods(1.03 at 0.4 ppm),at an operating temperature of 340℃.The enhanced acetone sensing performance may be attributed to the formation ofα-Fe_(2)O_(3)-SnO_(2) n-n heterostructure with 1D/2D hybrid architectures.Moreover,theα-Fe_(2)O_(3)/SnO_(2) HNAs also possess good reproducibility and selectivity toward acetone vapor,suggesting its potential application in breath acetone analysis.
文摘Lactoferrin(LF)shows good anticancer biological activity.Lactoferrin can combine with chlorogenic acid(CGA)in dairy drinks like milk coffee and milk tea.However,the nature and functional changes of LF after binding of CGA are not clear.The stability and binding properties of CGA on LF and its antiproliferative effect on colorectal cancer SW480 cells were investigated by spectroscopic and cell experiments.The results showed that CGA could stabilize LF solution by reducing particle size(below 90 nm)and increasing zeta potential(over 14 in the absolute value).With addition of CGA,the UV absorption peak of LF solution changed(from 287 nm shifted to 290 nm)and fluorescence quenching occurred at the same time.By molecular dynamics calculation,the binding site number of CGA to LF was between 2 and 3 sites.Negative Gibbs free energy of(△G=-25.75±0.84)indicated that the interaction between LF and CGA can occur spontaneously and effectively.Cell viability and apoptosis test showed that CGA and LF inhibited the growth of colorectal cancer SW480 cells in a synergistic way.Most of cells were arrested at G0/G1 phase by the CGA-LF complex.We conclude that CGA can bind to LF to form a relatively stable complex under natural conditions,which increases their antiproliferative function on colorectal cancer cells.
