Amphiphilic copolymers can self-assemble into nano-objects in aqueous solution.However,the selfassembly process is usually performed in a diluted solution(<1 wt%),which greatly limits scale-up production and furthe...Amphiphilic copolymers can self-assemble into nano-objects in aqueous solution.However,the selfassembly process is usually performed in a diluted solution(<1 wt%),which greatly limits scale-up production and further biomedical applications.With recent development of controlled polymerization techniques,polymerization-induced self-assembly(PISA)has emerged as an efficient approach for facile fabrication of nano-sized structures with a high concentration as high as 50 wt%.In this review,after the introduction,various polymerization method-mediated PISAs that include nitroxide-mediated polymerization-mediated PISA(NMP-PISA),reversible addition-fragmentation chain transfer polymerizationmediated PISA(RAFT-PISA),atom transfer radical polymerization-mediated PISA(ATRP-PISA),and ringopening polymerization-mediated PISA(ROP-PISA)are discussed carefully.Afterward,recent biomedical applications of PISA are illustrated from the following aspects,i.e.,bioimaging,disease treatment,biocatalysis,and antimicrobial.In the end,current achievements and future perspectives of PISA are given.It is envisioned that PISA strategy can bring great chance for future design and construction of functional nano-vehicles.展开更多
基金This work was financially supported from the Natural Science Foundation of Jiangsu Province(no.BK20200709)the Natural Science Foundation of China(no.62288102)+1 种基金the Natural Science Foundation of the Jiangsu Higher Education Institutes(no.20KJB430031)the startup fund from Nanjing Tech University.
文摘Amphiphilic copolymers can self-assemble into nano-objects in aqueous solution.However,the selfassembly process is usually performed in a diluted solution(<1 wt%),which greatly limits scale-up production and further biomedical applications.With recent development of controlled polymerization techniques,polymerization-induced self-assembly(PISA)has emerged as an efficient approach for facile fabrication of nano-sized structures with a high concentration as high as 50 wt%.In this review,after the introduction,various polymerization method-mediated PISAs that include nitroxide-mediated polymerization-mediated PISA(NMP-PISA),reversible addition-fragmentation chain transfer polymerizationmediated PISA(RAFT-PISA),atom transfer radical polymerization-mediated PISA(ATRP-PISA),and ringopening polymerization-mediated PISA(ROP-PISA)are discussed carefully.Afterward,recent biomedical applications of PISA are illustrated from the following aspects,i.e.,bioimaging,disease treatment,biocatalysis,and antimicrobial.In the end,current achievements and future perspectives of PISA are given.It is envisioned that PISA strategy can bring great chance for future design and construction of functional nano-vehicles.
