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NPM1 A型突变体对TGF-β1诱导K562细胞增殖及AKT磷酸化的影响 被引量:3
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作者 吴正财 王成艳 +2 位作者 吴香新 许昌声 林敏辉 《中国肿瘤临床》 CAS CSCD 北大核心 2019年第4期164-168,共5页
目的:观察核仁磷酸蛋白(nucleophosmin 1,NPM1)A型突变体过表达对TGF-β1诱导的K562细胞增殖及AKT磷酸化的影响。方法:腺病毒载体(Ad5-NPM1)转染髓系白血病K562细胞建立过表达NPM1蛋白细胞株;应用Western blot法及ELISA法分别检测细胞N... 目的:观察核仁磷酸蛋白(nucleophosmin 1,NPM1)A型突变体过表达对TGF-β1诱导的K562细胞增殖及AKT磷酸化的影响。方法:腺病毒载体(Ad5-NPM1)转染髓系白血病K562细胞建立过表达NPM1蛋白细胞株;应用Western blot法及ELISA法分别检测细胞NPM1蛋白表达及上清液含量,Westernblot法检测K562细胞NPM1、AKT和P-AKT蛋白表达,MTT法检测细胞增殖。结果:K562细胞NPM1蛋白表达水平呈Ad5-NPM1转染复数[(multiplicity of infection,MOI):30-200]依赖性增加,与空载组(Ad5-vector-100)相比,Ad5-NPM1-30、Ad5-NPM1-100组K562细胞及细胞上清液NPM1蛋白水平均显著增高(P<0.01)。TGF-β1(10ng/mL)能够诱导K562细胞AKT蛋白磷酸化,但对总AKT水平无明显影响。TGF-β1(10ng/mL)+Ad5-NPM1-100组K562细胞P-AKT水平显著高于TGF-β1处理组(P<0.05),各组总AKT水平无显著差别(P>0.05)。与空白对照组(CT)相比,TGF-β1(10ng/mL)处理可促进K562细胞增殖;但TGF-β1(10ng/mL)+Ad5-NPM1-100组细胞的增殖水平明显高于TGF-β1处理组(P<0.01)。结论:NPM1可促进TGF-β1诱导的K562细胞增殖。NPM1促进TGF-β1诱导的K562细胞可能与AKT磷酸化有关。 展开更多
关键词 核仁磷酸蛋白 K562细胞 TGF-Β1 P-AKT 细胞增殖
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LiZr_(2)(PO_(4))_(3)surface coating towards stable layer structure Li_(1.2)Mn_(0.54)Ni_(0.13)Co_(0.13)O_(2)cathode materials with long cycle performance
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作者 Hao Yang Jie Wang +4 位作者 changsheng xu Kewei Wu Fangfang Zou xuebu Hu Zhongli Hu 《Nano Research》 SCIE EI CSCD 2023年第2期2373-2382,共10页
Li-rich manganese-based materials are considered to be the mainstream cathode materials for next-generation lithium-ion batteries due to high discharge capacity and low cost,but poor cycle life and high temperature pe... Li-rich manganese-based materials are considered to be the mainstream cathode materials for next-generation lithium-ion batteries due to high discharge capacity and low cost,but poor cycle life and high temperature performance limit their development.Herein,LiZr_(2)(PO_(4))_(3)(LZPO)is coated on the surface of spherical Li_(1.2)Mn_(0.54)Ni_(0.13)Co_(0.13)O_(2)(LMNCO)material by a simple wet chemical method.The LZPO layer not only has the function of traditional coating layer to inhibit the occurrence of side reactions between electrolyte and LMNCO surface but also promotes the formation of spinel phase in the layered structure,increases the content of lattice oxygen,and reduces the content of absorbed oxygen.Thus,LZPO coated LMNCO has a more stable layered structure during cycling compared pure LMNCO,which improves effectively its long life and high temperature performance.The capacity loss rate of LZPO coated LMNCO is only 16.2%and 11.9%after 350 cycles at 25℃and 200 cycles at 50℃,respectively.Moreover,the capacity retention rate of the full cell composed of LZPO coated LMNCO and graphite is 70.7%after 200 cycles at 1.0 C.The coating layer toward stable surface structure can provide an idea for the modification of cathode materials,especially for Li-rich manganese-based materials. 展开更多
关键词 Li_(1.2)Mn_(0.54)Ni_(0.13)Co_(0.13)O_(2) LiZr_(2)(PO_(4))_(3) layered structure cycle life high temperature
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性别偏好、人力资本积累与企业信息化 被引量:7
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作者 李磊 徐长生 刘常青 《经济学(季刊)》 CSSCI 北大核心 2021年第1期181-200,共20页
本文基于第五次全国人口普查和2004年中国工业企业数据,利用Tobit模型考察了性别偏好对企业信息化的影响。研究发现,性别偏好越严重的地区,该地企业信息化水平越低。进一步的研究表明,性别偏好主要是通过人力资本水平这一渠道延缓了县... 本文基于第五次全国人口普查和2004年中国工业企业数据,利用Tobit模型考察了性别偏好对企业信息化的影响。研究发现,性别偏好越严重的地区,该地企业信息化水平越低。进一步的研究表明,性别偏好主要是通过人力资本水平这一渠道延缓了县区内企业信息化进程,具体而言,男孩偏好使得女性受教育水平降低,从而阻碍了整体人力资本水平的提升。此外,性别偏好的存在也导致了较低的教育投资效率。 展开更多
关键词 性别偏好 人力资本 资本技能互补
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Transformers in computational visual media:A survey 被引量:12
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作者 Yifan xu Huapeng Wei +7 位作者 Minxuan Lin Yingying Deng Kekai Sheng Mengdan Zhang Fan Tang Weiming Dong Feiyue Huang changsheng xu 《Computational Visual Media》 SCIE EI CSCD 2022年第1期33-62,共30页
Transformers,the dominant architecture for natural language processing,have also recently attracted much attention from computational visual media researchers due to their capacity for long-range representation and hi... Transformers,the dominant architecture for natural language processing,have also recently attracted much attention from computational visual media researchers due to their capacity for long-range representation and high performance.Transformers are sequence-to-sequence models,which use a selfattention mechanism rather than the RNN sequential structure.Thus,such models can be trained in parallel and can represent global information.This study comprehensively surveys recent visual transformer works.We categorize them according to task scenario:backbone design,high-level vision,low-level vision and generation,and multimodal learning.Their key ideas are also analyzed.Differing from previous surveys,we mainly focus on visual transformer methods in low-level vision and generation.The latest works on backbone design are also reviewed in detail.For ease of understanding,we precisely describe the main contributions of the latest works in the form of tables.As well as giving quantitative comparisons,we also present image results for low-level vision and generation tasks.Computational costs and source code links for various important works are also given in this survey to assist further development. 展开更多
关键词 visual transformer computational visual media(CVM) high-level vision low-level vision image generation multi-modal learning
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SiamCPN:Visual tracking with the Siamese center-prediction network 被引量:2
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作者 Dong Chen Fan Tang +2 位作者 Weiming Dong Hanxing Yao changsheng xu 《Computational Visual Media》 EI CSCD 2021年第2期253-265,共13页
Object detection is widely used in object tracking;anchor-free object tracking provides an end-to-end single-object-tracking approach.In this study,we propose a new anchor-free network,the Siamese center-prediction ne... Object detection is widely used in object tracking;anchor-free object tracking provides an end-to-end single-object-tracking approach.In this study,we propose a new anchor-free network,the Siamese center-prediction network(SiamCPN).Given the presence of referenced object features in the initial frame,we directly predict the center point and size of the object in subsequent frames in a Siamese-structure network without the need for perframe post-processing operations.Unlike other anchor-free tracking approaches that are based on semantic segmentation and achieve anchor-free tracking by pixel-level prediction,SiamCPN directly obtains all information required for tracking,greatly simplifying the model.A center-prediction sub-network is applied to multiple stages of the backbone to adaptively learn from the experience of different branches of the Siamese net.The model can accurately predict object location,implement appropriate corrections,and regress the size of the target bounding box.Compared to other leading Siamese networks,SiamCPN is simpler,faster,and more efficient as it uses fewer hyperparameters.Experiments demonstrate that our method outperforms other leading Siamese networks on GOT-10K and UAV123 benchmarks,and is comparable to other excellent trackers on LaSOT,VOT2016,and OTB-100 while improving inference speed 1.5 to 2 times. 展开更多
关键词 s Siamese network single object tracking anchor-free center point detection
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Efficacy and safety of systematic corticosteroids among severe COVID-19 patients:a systematic review and meta-analysis of randomized controlled trials 被引量:2
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作者 Shaolei Ma changsheng xu +5 位作者 Shijiang Liu Xiaodi Sun Renqi Li Mingjie Mao Shanwu Feng Xian Wang 《Signal Transduction and Targeted Therapy》 SCIE CSCD 2021年第3期756-762,共7页
The benefits and harms of corticosteroids for patients with severe coronavirus disease 2019(COVID-19)remain unclear.We systematically searched PubMed,Embase,and Cochrane Central Register of Controlled Trials from Dece... The benefits and harms of corticosteroids for patients with severe coronavirus disease 2019(COVID-19)remain unclear.We systematically searched PubMed,Embase,and Cochrane Central Register of Controlled Trials from December 31,2019 to October 1,2020 to identify randomized controlled trials(RCTs)that evaluated corticosteroids in severe COVID-19 patients.The primary outcome was all-cause mortality at the longest follow-up.Secondary outcomes included a composite disease progression(progression to intubation,ventilation,extracorporeal membrane oxygenation,ICU transfer,or death among those not ventilated at enrollment)and incidence of serious adverse events.A random-effects model was applied to calculate risk ratio(RR)with 95%confidence intervals(Cis).We used the Grading of Recommendations Assessment,Development,and Evaluation approach to evaluate the certainty of the evidence.Seven RCTs involving 6250 patients were included,of which the Randomized Evaluation of COVID-19 Therapy(RECOVERY)trial comprised nearly 78%of all included subjects.Results showed that corticosteroids were associated with a decreased all-cause mortality(27.3 vs.31.1%;RR:0.85;95%CI:0.73-0.99;P=0.04;low-certainty evidence).Trial sequential analysis suggested that more trials were still required to confirm the results.However,such survival benefit was absent if RECOVERY trial was excluded(RR:0.83;95%CI:0.65-1.06;P=0.13).Furthermore,corticosteroids decreased the occurrence of composite disease progression(30.6 vs.33.3%;RR:0.77;95%CI:0.64-0.92;P=0.005),but not increased the incidence of serious'adverse events(3.5 vs.3.4%;RR:1.16;95%CI:0.39-3.43;P=0.79). 展开更多
关键词 PATIENTS COR STEROIDS
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Non-dominated sorting based multi-page photo collage
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作者 Yu Song Fan Tang +1 位作者 Weiming Dong changsheng xu 《Computational Visual Media》 SCIE EI CSCD 2022年第2期199-212,共14页
The development of social networking services(SNSs)revealed a surge in image sharing.The sharing mode of multi-page photo collage(MPC),which posts several image collages at a time,can often be observed on many social ... The development of social networking services(SNSs)revealed a surge in image sharing.The sharing mode of multi-page photo collage(MPC),which posts several image collages at a time,can often be observed on many social network platforms,which enables uploading images and arrangement in a logical order.This study focuses on the construction of MPC for an image collection and its formulation as an issue of joint optimization,which involves not only the arrangement in a single collage but also the arrangement among different collages.Novel balance-aware measurements,which merge graphic features and psychological achievements,are introduced.Non-dominated sorting genetic algorithm is adopted to optimize the MPC guided by the measurements.Experiments demonstrate that the proposed method can lead to diverse,visually pleasant,and logically clear MPC results,which are comparable to manually designed MPC results. 展开更多
关键词 multi-page photo collage balance-aware measurements non-dominated sorting genetic algorithm
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Perspective:Societally connected multimedia across cultures
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作者 Zhongfei ZHANG Zhengyou ZHANG +14 位作者 Ramesh JAIN Yueting ZHUANG Noshir CONTRACTOR Alexander G. HAUPTMANN Alejandro (Alex) JAIMES Wanqing LI Alexander C. LOUI Tao MEI Nicu SEBE Yonghong TIAN Vincent S. TSENG Qing WANG changsheng xu Huimin YU Shiwen YU 《Journal of Zhejiang University-Science C(Computers and Electronics)》 SCIE EI 2012年第12期875-880,共6页
The advance of the Internet in the past decade has radically changed the way people communicate and col- laborate with each other. Physical distance is no more a barrier in online social networks, but cultural differe... The advance of the Internet in the past decade has radically changed the way people communicate and col- laborate with each other. Physical distance is no more a barrier in online social networks, but cultural differences (at the individual, community, as well as societal levels) still govern human-human interactions and must be con- sidered and leveraged in the online world. The rapid deployment of high-speed lnternet allows humans to interact using a rich set of multimedia data such as texts, pictures, and videos. This position paper proposes to define a new research area called 'connected multimedia', which is the study of a collection of research issues of the super-area social media that receive little attention in the literature. By connected multimedia, we mean the study of the social and technical interactions among users, multimedia data, and devices across cultures and explicitly exploiting the cultural differences. We justify why it is necessary to bring attention to this new research area and what benefits of this new research area may bring to the broader scientific research community and the humanity. 展开更多
关键词 Connected multimedia Social media Social-cultural constraint
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