Objective： To evaluate the effects of botulinum toxin type A （BTX-A） on mandible skeletal development by inducing muscle hypofunction. Methods： Four-week-old Sprague-Dawley rats （n=60） were divided into three gr...Objective： To evaluate the effects of botulinum toxin type A （BTX-A） on mandible skeletal development by inducing muscle hypofunction. Methods： Four-week-old Sprague-Dawley rats （n=60） were divided into three groups： Group 1 animals served as controls and were injected with saline; Group 2 animals were injected unilaterally with BTX-A （the contralateral side was injected with saline）; and Group 3 animals were injected bilaterally with BTX-A. In Group 2, the saline-injected side was designated the control side （Group 2-1）, whereas the BTX-A-injected side was designated the experimental side （Group 2-2）. After four weeks, the animals were sacrificed, dry skulls were prepared, and mandibles were measured. Results： In the unilateral group, the experimental side （Group 2-2） had reduced di- mensions for all mandible measurements compared with the control side （Group 2-1）, suggesting a local effect of BTX-A on mandible growth, likely due to muscle reduction. Conclusions： Localized BTX-A injection induced a change in craniofacial growth, and the skeletal effect was unilateral despite both sides of the mandible functioning as one unit.展开更多
基金supported by the Samsung Biomedical Research Institute Grant(No.CA53061),Korea
文摘Objective： To evaluate the effects of botulinum toxin type A （BTX-A） on mandible skeletal development by inducing muscle hypofunction. Methods： Four-week-old Sprague-Dawley rats （n=60） were divided into three groups： Group 1 animals served as controls and were injected with saline; Group 2 animals were injected unilaterally with BTX-A （the contralateral side was injected with saline）; and Group 3 animals were injected bilaterally with BTX-A. In Group 2, the saline-injected side was designated the control side （Group 2-1）, whereas the BTX-A-injected side was designated the experimental side （Group 2-2）. After four weeks, the animals were sacrificed, dry skulls were prepared, and mandibles were measured. Results： In the unilateral group, the experimental side （Group 2-2） had reduced di- mensions for all mandible measurements compared with the control side （Group 2-1）, suggesting a local effect of BTX-A on mandible growth, likely due to muscle reduction. Conclusions： Localized BTX-A injection induced a change in craniofacial growth, and the skeletal effect was unilateral despite both sides of the mandible functioning as one unit.
