Objective To summarize the acupoint selection rule for chronic gastritis treated with acupuncture and moxibustion so as to provide a certain evidence for clinical practice and scientific research.Methods By searching ...Objective To summarize the acupoint selection rule for chronic gastritis treated with acupuncture and moxibustion so as to provide a certain evidence for clinical practice and scientific research.Methods By searching journal literature on chronic gastritis treated with acupuncture and moxibustion in recent 10 years,with data mining,the acupoints screened from literature were analyzed.Results A total of 803 articles were included finally.Conception vessel,stomach meridian and bladder meridian were mostly selected,the acupoints were selected from the abdomen,the thigh/crus,the back and the arms.The top 5 aucpoints with high frequency were Zúsānǐ(足三里ST36),Zhōngwǎn(中脘CV12),Wèishū(胃俞BL21)(332),Píshū(脾俞BL20)and Nèiguān(内关PC6).The top 5 acupoint combinations with high frequency included CV12 combined with ST36,BL21 with CV12,BL21 with ST35 and BL20 with CV12.The mostly used specific points were front-mu point,he-sea point,crossing point and back-shu point.Conclusion In treatment of chronic gastritis with acupuncture and moxibustion,conception vessel,stomach meridian and bladder meridian are particularly selected in combination and the specific points with duplicate effect are mostly selected,especially focusing on the application of front-mu point.展开更多
Objective:To explore whether there is a specific clinical effect of acupuncture in the treatment of chronic prostatitis.Methods:A total of 52 patients with chronic prostatitis were randomly divided into an acupuncture...Objective:To explore whether there is a specific clinical effect of acupuncture in the treatment of chronic prostatitis.Methods:A total of 52 patients with chronic prostatitis were randomly divided into an acupuncture group(24 cases) and a placebo acupuncture group(28 cases).During the treatment,1 case was dropped out in the placebo acupuncture group and 51 patients accomplished the clinical trial finally in two groups.In the acupuncture group,Shènshū(肾俞BL23),Zhōngliáo(中髎BL33),Huìyáng(会阳BL35) and Sānyīnjiāo(三阴交SP6) were selected.In the placebo acupuncture group,the non-meridian points located lateral to BL23,BL33,BL35 and SP6 were selected,respectively.The duration of treatment was 8 weeks in each group.In the first 4 weeks of treatment,the treatment was given once every two days,three times weekly.In the last 4 weeks of treatment,the treatment was given once every three days,twice a week.Totally,20 acupuncture treatments were required in the whole trial.Before treatment,in week 4 and 8 of treatment and in follow-up,National Institutes of Health Chronic Prostatitis Symptom Index(NIH-CPSI) score and the comprehensive effect were evaluated in the two groups successively.Results:In week 4 and 8 of treatment,NIH-CPSI score in the acupuncture group was lower than that before treatment,respectively(both P <0.05).In week 8 of treatment,NIH-CPSI score in the placebo acupuncture group was lower than that before treatment(P <0.05).NIH-CPSI score in the acupuncture group was lower than the placebo acupuncture group in week 8 of treatment(P <0.05).In followup,NIH-CPSI score of the two groups all decreased as compared with the score before treatment(both P <0.05),and the score in the acupuncture group was lower than the placebo acupuncture group(P <0.05).In the comparison of comprehensive effect,the total effective rate was 91.7% in the acupuncture group and was 74.1% in the placebo acupuncture group.The therapeutic effect in the acupuncture group was better than that of the placebo acupuncture group(P <0.05).Conclusion:Acupuncture relieves pelvic pain and urination symptoms and has a certain of long-term effect in patients with chronic prostatitis.展开更多
Objective:To observe the clinical effect of combined acupuncture and kinesiotherapy on upper cross syndrome(UCS) by a parallel randomized clinical trial.Methods:A total of 45 patients with UCS were recruited from the ...Objective:To observe the clinical effect of combined acupuncture and kinesiotherapy on upper cross syndrome(UCS) by a parallel randomized clinical trial.Methods:A total of 45 patients with UCS were recruited from the outpatients of AcupunctureMoxibustion,Tuina and Rehabilitation Department of the First Affiliated Hospital of Hunan University of Chinese Medicine,the students of Hunan University of Chinese Medicine and the patients from the nearby communities in accordance with the inclusion criteria.Using the random number table method,they were divided into a combined treatment group(acupuncture plus kinesiotherapy,23 cases) and a simple kinesiotherapy group(22 patients).Treatment for 4 weeks was one course,and two consecutive courses were required.The visual analog scale(VAS) score,the score of the assessment scale for cervical spondylosis,the value of surface electromyography(root mean square,RMS),and the cervical curvature value were used in the evaluation.The allocation scheme was concealed from the outcome assessors.Results:The data from 23 cases of the combined treatment group and 22 cases of the simple kinesiotherapy group were analyzed.Before treatment,the differences were not statistically significant in the general conditions,VAS score,assessment score of cervical spondylosis,cervical curvature value,and RMS in UCS patients between the two groups(all P> 0.05).After treatment,the VAS score was reduced compared with that before treatment in both groups(all P <0.05).In two courses of treatment,the VAS score decreased as compared with that in one course of treatment in both groups(both P <0.05),and the VAS score in the combined treatment group decreased more obviously after each course of treatment(both P <0.05).The RMS decreased compared with that before treatment in each group(both P <0.05),and the decrease in the combined treatment group was more obvious(P <0.05).After treatment of each course,the assessment score was all increased as compared with that before treatment in two groups(all P <0.05).In two courses of treatment,the assessment score was increased as compared with that in one course of treatment in both groups(both P <0.05),and the score in the combined treatment group was increased more obviously in the two courses of treatment(P <0.05).Regarding either the intra-group comparison or the inter-group comparison before and after treatment,the differences were not statistically significant(all P> 0.05),suggesting no obvious improvement of cervical curvature in the two courses of treatment in patients with UCS.However,cervical curvature tended to improve in the combined treatment group.The total effective rate was significantly different between the two groups(P <0.05),indicating that the total effective rate in the combined treatment group was better than that in the simple kinesiotherapy group.No any adverse reactions occurred.Conclusion:Combined treatment with acupuncture,kinesiotherapy,and kinesiotherapy alleviated pain,relieved the symptoms and physical signs,and improved the daily movement of the patients.However,the combined treatment of acupuncture and kinesiotherapy had a much better effect on UCS.展开更多
Molecules with long preserved magnetic moments are perceived as the smallest units for storing bytes,which could bring a new revolution for information technology.However,the rational design of such molecules remains ...Molecules with long preserved magnetic moments are perceived as the smallest units for storing bytes,which could bring a new revolution for information technology.However,the rational design of such molecules remains challenging.Here two rigid adamantanol ligand based dysprosium(III)complexes([Dy(1-AdO)_(2)(py)_(5)]BPh_(4)-1 and[Dy(2-AdO)_(2)(py)_(5)]BPh_(4)-2)with pentagonal-bipyramidal coordination geometry and local D5h symmetry were successfully prepared,which display excellent single-molecule magnet(SMM)behavior(U_(eff)≈1835 K,T_(B)_(ZFC)≈24 K,T_(B)^(100s)≈17 K and T_(B)^(H)=23 K for 1;U_(eff)≈1756 K,T_(B)^(ZFC)≈20 K,T_(B)^(100s)≈16 K and T_(B)^(H)=23 K for 2)due to the much weakened vibration in low energy regimes.Remarkably,the large energy barriers and high blocking temperatures for these two complexes in solid states are well preserved in solution.This is never observed in previous studies of SMMs,indicating that the adamantanol is rigid and can be introduced to make the composed molecules stable enough to maintain the solid state magnetic property in solution.展开更多
Background:Vessels with different microcirculation patterns are required for glioblastoma(GBM)growth.However,details of the microcirculation patterns in GBM remain unclear.Here,we examined the microcirculation pattern...Background:Vessels with different microcirculation patterns are required for glioblastoma(GBM)growth.However,details of the microcirculation patterns in GBM remain unclear.Here,we examined the microcirculation patterns of GBM and analyzed their roles in patient prognosis together with two well-known GMB prognosis factors(O^(6)-methylguanine DNA methyltransferase[MGMT]promoter methylation status and isocitrate dehydrogenase[IDH]mutations).Methods:Eighty GBM clinical specimens were collected from patients diagnosed between January 2000 and December 2012.The microcirculation patterns,including endothelium-dependent vessels(EDVs),extracellular matrix-dependent vessels(ECMDVs),GBM cell-derived vessels(GDVs),and mosaic vessels(MVs),were evaluated by immunohistochemistry(IHC)and immunofluorescence(IF)staining in both GBM clinical specimens and xenograft tissues.Vascular density assessments and three-dimensional reconstruction were performed.MGMT promoter methylation status was determined by methylation-specific PCR,and IDH1/2 mutations were detected by Sanger sequencing.The relationship between the microcirculation patterns and patient prognosis was analyzed by Kaplan-Meier method.Results:All 4 microcirculation patterns were observed in both GBM clinical specimens and xenograft tissues.EDVs were detected in all tissue samples,while the other three patterns were observed in a small number of tissue samples(ECMDVs in 27.5%,GDVs in 43.8%,and MVs in 52.5%tissue samples).GDV-positive patients had a median survival of 9.56 months versus 13.60 months for GDV-negative patients(P=0.015).In MGMT promoter-methylated cohort,GDV-positive patients had a median survival of 6.76 months versus 14.23 months for GDV-negative patients(P=0.022).Conclusion:GDVs might be a negative predictor for the survival of GBM patients,even in those with MGMT promoter methylation.展开更多
基金Supported by National Basic Research Program of China(973):2015CB554502Graduate Candidate Innovation Project of Hunan University of Chinese Medicine:2020CX67。
文摘Objective To summarize the acupoint selection rule for chronic gastritis treated with acupuncture and moxibustion so as to provide a certain evidence for clinical practice and scientific research.Methods By searching journal literature on chronic gastritis treated with acupuncture and moxibustion in recent 10 years,with data mining,the acupoints screened from literature were analyzed.Results A total of 803 articles were included finally.Conception vessel,stomach meridian and bladder meridian were mostly selected,the acupoints were selected from the abdomen,the thigh/crus,the back and the arms.The top 5 aucpoints with high frequency were Zúsānǐ(足三里ST36),Zhōngwǎn(中脘CV12),Wèishū(胃俞BL21)(332),Píshū(脾俞BL20)and Nèiguān(内关PC6).The top 5 acupoint combinations with high frequency included CV12 combined with ST36,BL21 with CV12,BL21 with ST35 and BL20 with CV12.The mostly used specific points were front-mu point,he-sea point,crossing point and back-shu point.Conclusion In treatment of chronic gastritis with acupuncture and moxibustion,conception vessel,stomach meridian and bladder meridian are particularly selected in combination and the specific points with duplicate effect are mostly selected,especially focusing on the application of front-mu point.
基金Supported by Special Funded Project for Basic Scientific Research Operation Expenses of Central Public Welfare Scientific Research Institutes:No.49916。
文摘Objective:To explore whether there is a specific clinical effect of acupuncture in the treatment of chronic prostatitis.Methods:A total of 52 patients with chronic prostatitis were randomly divided into an acupuncture group(24 cases) and a placebo acupuncture group(28 cases).During the treatment,1 case was dropped out in the placebo acupuncture group and 51 patients accomplished the clinical trial finally in two groups.In the acupuncture group,Shènshū(肾俞BL23),Zhōngliáo(中髎BL33),Huìyáng(会阳BL35) and Sānyīnjiāo(三阴交SP6) were selected.In the placebo acupuncture group,the non-meridian points located lateral to BL23,BL33,BL35 and SP6 were selected,respectively.The duration of treatment was 8 weeks in each group.In the first 4 weeks of treatment,the treatment was given once every two days,three times weekly.In the last 4 weeks of treatment,the treatment was given once every three days,twice a week.Totally,20 acupuncture treatments were required in the whole trial.Before treatment,in week 4 and 8 of treatment and in follow-up,National Institutes of Health Chronic Prostatitis Symptom Index(NIH-CPSI) score and the comprehensive effect were evaluated in the two groups successively.Results:In week 4 and 8 of treatment,NIH-CPSI score in the acupuncture group was lower than that before treatment,respectively(both P <0.05).In week 8 of treatment,NIH-CPSI score in the placebo acupuncture group was lower than that before treatment(P <0.05).NIH-CPSI score in the acupuncture group was lower than the placebo acupuncture group in week 8 of treatment(P <0.05).In followup,NIH-CPSI score of the two groups all decreased as compared with the score before treatment(both P <0.05),and the score in the acupuncture group was lower than the placebo acupuncture group(P <0.05).In the comparison of comprehensive effect,the total effective rate was 91.7% in the acupuncture group and was 74.1% in the placebo acupuncture group.The therapeutic effect in the acupuncture group was better than that of the placebo acupuncture group(P <0.05).Conclusion:Acupuncture relieves pelvic pain and urination symptoms and has a certain of long-term effect in patients with chronic prostatitis.
基金Supported by Leading Talents Training Program of Hunan Province High-Level Health Talents 225 Project (Hunan Health-20N9-N9S)。
文摘Objective:To observe the clinical effect of combined acupuncture and kinesiotherapy on upper cross syndrome(UCS) by a parallel randomized clinical trial.Methods:A total of 45 patients with UCS were recruited from the outpatients of AcupunctureMoxibustion,Tuina and Rehabilitation Department of the First Affiliated Hospital of Hunan University of Chinese Medicine,the students of Hunan University of Chinese Medicine and the patients from the nearby communities in accordance with the inclusion criteria.Using the random number table method,they were divided into a combined treatment group(acupuncture plus kinesiotherapy,23 cases) and a simple kinesiotherapy group(22 patients).Treatment for 4 weeks was one course,and two consecutive courses were required.The visual analog scale(VAS) score,the score of the assessment scale for cervical spondylosis,the value of surface electromyography(root mean square,RMS),and the cervical curvature value were used in the evaluation.The allocation scheme was concealed from the outcome assessors.Results:The data from 23 cases of the combined treatment group and 22 cases of the simple kinesiotherapy group were analyzed.Before treatment,the differences were not statistically significant in the general conditions,VAS score,assessment score of cervical spondylosis,cervical curvature value,and RMS in UCS patients between the two groups(all P> 0.05).After treatment,the VAS score was reduced compared with that before treatment in both groups(all P <0.05).In two courses of treatment,the VAS score decreased as compared with that in one course of treatment in both groups(both P <0.05),and the VAS score in the combined treatment group decreased more obviously after each course of treatment(both P <0.05).The RMS decreased compared with that before treatment in each group(both P <0.05),and the decrease in the combined treatment group was more obvious(P <0.05).After treatment of each course,the assessment score was all increased as compared with that before treatment in two groups(all P <0.05).In two courses of treatment,the assessment score was increased as compared with that in one course of treatment in both groups(both P <0.05),and the score in the combined treatment group was increased more obviously in the two courses of treatment(P <0.05).Regarding either the intra-group comparison or the inter-group comparison before and after treatment,the differences were not statistically significant(all P> 0.05),suggesting no obvious improvement of cervical curvature in the two courses of treatment in patients with UCS.However,cervical curvature tended to improve in the combined treatment group.The total effective rate was significantly different between the two groups(P <0.05),indicating that the total effective rate in the combined treatment group was better than that in the simple kinesiotherapy group.No any adverse reactions occurred.Conclusion:Combined treatment with acupuncture,kinesiotherapy,and kinesiotherapy alleviated pain,relieved the symptoms and physical signs,and improved the daily movement of the patients.However,the combined treatment of acupuncture and kinesiotherapy had a much better effect on UCS.
基金This work was supported by the National Natural Science Foundation of China(Nos.21773130,21871219 and 21971203)the Key Laboratory Construction Program of Xi'an Municipal Bu-reau of Science and Technology(No.201805056ZD7CG40)+1 种基金the Key Scientific and Technological Innovation Team of Shaanxi Province(No.2020TD-001)the Fundamental Research Funds for Central Universities。
文摘Molecules with long preserved magnetic moments are perceived as the smallest units for storing bytes,which could bring a new revolution for information technology.However,the rational design of such molecules remains challenging.Here two rigid adamantanol ligand based dysprosium(III)complexes([Dy(1-AdO)_(2)(py)_(5)]BPh_(4)-1 and[Dy(2-AdO)_(2)(py)_(5)]BPh_(4)-2)with pentagonal-bipyramidal coordination geometry and local D5h symmetry were successfully prepared,which display excellent single-molecule magnet(SMM)behavior(U_(eff)≈1835 K,T_(B)_(ZFC)≈24 K,T_(B)^(100s)≈17 K and T_(B)^(H)=23 K for 1;U_(eff)≈1756 K,T_(B)^(ZFC)≈20 K,T_(B)^(100s)≈16 K and T_(B)^(H)=23 K for 2)due to the much weakened vibration in low energy regimes.Remarkably,the large energy barriers and high blocking temperatures for these two complexes in solid states are well preserved in solution.This is never observed in previous studies of SMMs,indicating that the adamantanol is rigid and can be introduced to make the composed molecules stable enough to maintain the solid state magnetic property in solution.
基金National Basic Research Program of China,Grant/Award Number:2015CB755505National Natural Science Foundation of China,Grant/Award Numbers:30973478,81372685,81572479,81672484+4 种基金Guangzhou Science Technology Project,Grant/Award Numbers:201508020125,201803010056Science and Technology Planning Project of Guangdong Province,Grant/Award Number:2016A020213004Natural Science Foundation of Guangdong Province,Grant/Award Number:S2013040012894Shenzhen Innovation Project of Scientific and Technology,Grant/Award Number:JCYJ20140416094330210We sincerely appreciate the generous help from the core facility in the Department of Experimental Research,Sun Yat-sen University Cancer Center.
文摘Background:Vessels with different microcirculation patterns are required for glioblastoma(GBM)growth.However,details of the microcirculation patterns in GBM remain unclear.Here,we examined the microcirculation patterns of GBM and analyzed their roles in patient prognosis together with two well-known GMB prognosis factors(O^(6)-methylguanine DNA methyltransferase[MGMT]promoter methylation status and isocitrate dehydrogenase[IDH]mutations).Methods:Eighty GBM clinical specimens were collected from patients diagnosed between January 2000 and December 2012.The microcirculation patterns,including endothelium-dependent vessels(EDVs),extracellular matrix-dependent vessels(ECMDVs),GBM cell-derived vessels(GDVs),and mosaic vessels(MVs),were evaluated by immunohistochemistry(IHC)and immunofluorescence(IF)staining in both GBM clinical specimens and xenograft tissues.Vascular density assessments and three-dimensional reconstruction were performed.MGMT promoter methylation status was determined by methylation-specific PCR,and IDH1/2 mutations were detected by Sanger sequencing.The relationship between the microcirculation patterns and patient prognosis was analyzed by Kaplan-Meier method.Results:All 4 microcirculation patterns were observed in both GBM clinical specimens and xenograft tissues.EDVs were detected in all tissue samples,while the other three patterns were observed in a small number of tissue samples(ECMDVs in 27.5%,GDVs in 43.8%,and MVs in 52.5%tissue samples).GDV-positive patients had a median survival of 9.56 months versus 13.60 months for GDV-negative patients(P=0.015).In MGMT promoter-methylated cohort,GDV-positive patients had a median survival of 6.76 months versus 14.23 months for GDV-negative patients(P=0.022).Conclusion:GDVs might be a negative predictor for the survival of GBM patients,even in those with MGMT promoter methylation.
