Protein tyrosine phosphatase 1 B （PTP1 B） has received considerable attention from the drug industry as a potential treatment for diabetes mellitus. Mangiferin has been reported to possess significant antidiabetic a...Protein tyrosine phosphatase 1 B （PTP1 B） has received considerable attention from the drug industry as a potential treatment for diabetes mellitus. Mangiferin has been reported to possess significant antidiabetic activity. Based on the previous study, eight new mangiferin derivates were synthesized and evaluated for their PTP1B inhibitory activity. Some of them displayed good inhibitory activity on PTP1B.展开更多
Based on the active site of Candida albicans lanosterol 14α-demethylase (CACYP51), novel triazole compounds structurally different from the current triazole drugs were designed and synthesized. In vitro antifungal ac...Based on the active site of Candida albicans lanosterol 14α-demethylase (CACYP51), novel triazole compounds structurally different from the current triazole drugs were designed and synthesized. In vitro antifungal activities showed that compounds 10, 11, 16 and 20 exhibited strong activities. In addition, compounds 10, 11 and 16 also displayed certain activities against fluconazole-resistant fungi.展开更多
In this paper we prove that the boundedness and compactness of Toeplitz operator with a BMOα1 symbol on the weighted Bergman space Aα2（Bn） of the unit ball is completely determined by the behavior of its Berezin t...In this paper we prove that the boundedness and compactness of Toeplitz operator with a BMOα1 symbol on the weighted Bergman space Aα2（Bn） of the unit ball is completely determined by the behavior of its Berezin transform, where ≥ -1 and n 〉 1.展开更多
文摘Protein tyrosine phosphatase 1 B （PTP1 B） has received considerable attention from the drug industry as a potential treatment for diabetes mellitus. Mangiferin has been reported to possess significant antidiabetic activity. Based on the previous study, eight new mangiferin derivates were synthesized and evaluated for their PTP1B inhibitory activity. Some of them displayed good inhibitory activity on PTP1B.
文摘Based on the active site of Candida albicans lanosterol 14α-demethylase (CACYP51), novel triazole compounds structurally different from the current triazole drugs were designed and synthesized. In vitro antifungal activities showed that compounds 10, 11, 16 and 20 exhibited strong activities. In addition, compounds 10, 11 and 16 also displayed certain activities against fluconazole-resistant fungi.
基金Supported by National Natural Science Foundation of China （Grant Nos. 10671028, 10971020）
文摘In this paper we prove that the boundedness and compactness of Toeplitz operator with a BMOα1 symbol on the weighted Bergman space Aα2（Bn） of the unit ball is completely determined by the behavior of its Berezin transform, where ≥ -1 and n 〉 1.
