Named Entity Recognition(NER)stands as a fundamental task within the field of biomedical text mining,aiming to extract specific types of entities such as genes,proteins,and diseases from complex biomedical texts and c...Named Entity Recognition(NER)stands as a fundamental task within the field of biomedical text mining,aiming to extract specific types of entities such as genes,proteins,and diseases from complex biomedical texts and categorize them into predefined entity types.This process can provide basic support for the automatic construction of knowledge bases.In contrast to general texts,biomedical texts frequently contain numerous nested entities and local dependencies among these entities,presenting significant challenges to prevailing NER models.To address these issues,we propose a novel Chinese nested biomedical NER model based on RoBERTa and Global Pointer(RoBGP).Our model initially utilizes the RoBERTa-wwm-ext-large pretrained language model to dynamically generate word-level initial vectors.It then incorporates a Bidirectional Long Short-Term Memory network for capturing bidirectional semantic information,effectively addressing the issue of long-distance dependencies.Furthermore,the Global Pointer model is employed to comprehensively recognize all nested entities in the text.We conduct extensive experiments on the Chinese medical dataset CMeEE and the results demonstrate the superior performance of RoBGP over several baseline models.This research confirms the effectiveness of RoBGP in Chinese biomedical NER,providing reliable technical support for biomedical information extraction and knowledge base construction.展开更多
Although 9.4 T magnetic resonance imaging(MRI) has been tested in healthy volunteers,its safety in diabetic patients is unclear.Furthermore,the effects of high static magnetic fields(SMFs),especially gradient vs.unifo...Although 9.4 T magnetic resonance imaging(MRI) has been tested in healthy volunteers,its safety in diabetic patients is unclear.Furthermore,the effects of high static magnetic fields(SMFs),especially gradient vs.uniform fields,have not been investigated in diabetics.Here,we investigated the consequences of exposure to 1.0-9.4 T high SMFs of different gradients(>10 T/m vs.0-10 T/m)on type 1 diabetic(T1D) and type 2 diabetic(T2D) mice.We found that 14 h of prolonged treatment of gradient(as high as 55.5 T/m) high SMFs(1.0-8.6 T) had negative effects on T1D and T2D mice,including spleen,hepatic,and renal tissue impairment and elevated glycosylated serum protein,blood glucose,inflammation,and anxiety,while 9.4 T quasi-uniform SMFs at 0-10 T/m did not induce the same effects.In regular T1D mice(blood glucose>16.7 mmol/L),the>10 T/m gradient high SMFs increased malondialdehyde(P<0.01) and decreased superoxide dismutase(P<0.05).However,in the severe T1D mice(blood glucose≥30.0 mmol/L),the>10 T/m gradient high SMFs significantly increased tissue damage and reduced survival rate.In vitro cellular studies showed that gradient high SMFs increased cellular reactive oxygen species and apoptosis and reduced MS-1 cell number and proliferation.Therefore,this study showed that prolonged exposure to high-field(1.0-8.6 T)>10 T/m gradient SMFs(35-1 380 times higher than that of current clinical MRI)can have negative effects on diabetic mice,especially mice with severe T1D,whereas 9.4 T high SMFs at 0-10T/m did not produce the same effects,providing important information for the future development and clinical application of SMFs,especially high-field MRI.展开更多
Heavy metal distribution in mining areas has always been a hot research topic due to the special environment of these areas. This study aims to explore the impact of heavy metal pollution on soils and crops in the stu...Heavy metal distribution in mining areas has always been a hot research topic due to the special environment of these areas. This study aims to explore the impact of heavy metal pollution on soils and crops in the study area, ensure the safety of local crops and the health of local residents, and provide a basis for the subsequent environmental restoration and the prevention and control of environmental pollution. Based on the analysis of the heavy metal concentrations in local soils and crops, the study investigated the spatial distribution, pollution degrees, and potential ecological risks of heavy metals in the farmland of a mining area in the southeastern Nanyang Basin, Henan province, China explored the sources of heavy metals and assessed the health risks caused by crop intake. The results of this study are as follows. The root soils of crops in the study area suffered heavy metal pollution to varying degrees. The degree of heavy metal pollution in maize fields is higher than that in wheat fields, and both types of fields suffer the most severe Cd pollution. Moreover, the root soils of different crops suffer compound pollution.The root soils in the maize fields suffer severe compound pollution at some sampling positions, whose distribution is similar to that of the mining area. Cd poses the highest potential ecological risks among all heavy metals, and the study area mainly suffers low and moderate comprehensive potential ecological risks. The principal component analysis(PCA) shows that the distribution of Zn, Cd, Pb, and As in soils of the study area is mainly affected by anthropogenic factors such as local mining activities;the distribution of Cr and Ni is primarily controlled by the local geological background;the distribution of Hg is mainly affected by local vehicle exhaust emissions, and the distribution of Cu is influenced by both human activities and the geological background. Different cereal crops in the study area are polluted with heavy metals dominated by Cd and Ni to varying degrees, especially wheat. As indicated by the health risk assessment results, the intake of maize in the study area does not pose significant human health risks;however, Cu has high risks to human health, and the compound heavy metal pollution caused by the intake of wheat in the study area poses risks to the health of both adults and children. Overall, the soils and crops in the study area suffer a high degree of heavy metal pollution, for which mining activities may be the main reason.展开更多
Relationship between sea level change and a single climate indicator has been widely discussed.However,few studies focused on the relationship between monthly mean sea level(MMSL)and several key impact factors,includi...Relationship between sea level change and a single climate indicator has been widely discussed.However,few studies focused on the relationship between monthly mean sea level(MMSL)and several key impact factors,including CO_(2) concentration,sea ice area,and sunspots,on various time scales.In addition,research on the independent relationship between climate factors and sea level on various time scales is lacking,especially when the dependence of climate factors on Nino 3.4 is excluded.Based on this,we use wavelet coherence(WC)and partial wavelet coherence(PWC)to establish a relationship between MMSL and its influencing factors.The WC results show that the influence of climate indices on MMSL has strong regional characteristics.The significant correlation between Southern Hemisphere sea ice area and MMSL is opposite to that between Northern Hemisphere sea ice area and MMSL.The PWC results show that after removing the influence of Nino 3.4,the significant coherent regions of the Pacific Decadal Oscillation(PDO),Dipole Mode Index(DMI),Atlantic Multidecadal Oscillation(AMO),and Southern Oscillation Index(SOI)decrease to varying degrees on different time scales in different regions,demonstrating the influence of Nino 3.4.Our work emphasizes the interrelationship and independent relationship between MMSL and its influencing factors on various time scales and the use of PWC and WC to describe this relationship.The study has an important reference significance for selecting the best predictors of sea level change or climate systems.展开更多
Non-Abelian anyons are exotic quasiparticle excitations hosted by certain topological phases of matter.They break the fermion-boson dichotomy and obey non-Abelian braiding statistics:their interchanges yield unitary o...Non-Abelian anyons are exotic quasiparticle excitations hosted by certain topological phases of matter.They break the fermion-boson dichotomy and obey non-Abelian braiding statistics:their interchanges yield unitary operations,rather than merely a phase factor,in a space spanned by topologically degenerate wavefunctions.They are the building blocks of topological quantum computing.However,experimental observation of non-Abelian anyons and their characterizing braiding statistics is notoriously challenging and has remained elusive hitherto,in spite of various theoretical proposals.Here,we report an experimental quantum digital simulation of projective non-Abelian anyons and their braiding statistics with up to 68 programmable superconducting qubits arranged on a two-dimensional lattice.By implementing the ground states of the toric-code model with twists through quantum circuits,we demonstrate that twists exchange electric and magnetic charges and behave as a particular type of non-Abelian anyons,i.e.,the Ising anyons.In particular,we show experimentally that these twists follow the fusion rules and non-Abelian braiding statistics of the Ising type,and can be explored to encode topological logical qubits.Furthermore,we demonstrate how to implement both single-and two-qubit logic gates through applying a sequence of elementary Pauli gates on the underlying physical qubits.Our results demonstrate a versatile quantum digital approach for simulating non-Abelian anyons,offering a new lens into the study of such peculiar quasiparticles.展开更多
BACKGROUND Postoperative liver failure is the most severe complication in cirrhotic patients with hepatocellular carcinoma(HCC) after major hepatectomy. Current available clinical indexes predicting postoperative resi...BACKGROUND Postoperative liver failure is the most severe complication in cirrhotic patients with hepatocellular carcinoma(HCC) after major hepatectomy. Current available clinical indexes predicting postoperative residual liver function are not sufficiently accurate.AIM To determine a radiomics model based on preoperative gadoxetic acid-enhanced magnetic resonance imaging for predicting liver failure in cirrhotic patients with HCC after major hepatectomy.METHODS For this retrospective study, a radiomics-based model was developed based on preoperative hepatobiliary phase gadoxetic acid-enhanced magnetic resonance images in 101 patients with HCC between June 2012 and June 2018. Sixty-one radiomic features were extracted from hepatobiliary phase images and selected by the least absolute shrinkage and selection operator method to construct a radiomics signature. A clinical prediction model, and radiomics-based model incorporating significant clinical indexes and radiomics signature were built using multivariable logistic regression analysis. The integrated radiomics-based model was presented as a radiomics nomogram. The performances of clinical prediction model, radiomics signature, and radiomics-based model for predicting post-operative liver failure were determined using receiver operating characteristics curve, calibration curve, and decision curve analyses.RESULTS Five radiomics features from hepatobiliary phase images were selected to construct the radiomics signature. The clinical prediction model, radiomics signature, and radiomics-based model incorporating indocyanine green clearance rate at 15 min and radiomics signature showed favorable performance for predicting postoperative liver failure(area under the curve: 0.809-0.894). The radiomics-based model achieved the highest performance for predicting liver failure(area under the curve: 0.894;95%CI: 0.823-0.964). The integrated discrimination improvement analysis showed a significant improvement in the accuracy of liver failure prediction when radiomics signature was added to the clinical prediction model(integrated discrimination improvement = 0.117, P =0.002). The calibration curve and an insignificant Hosmer-Lemeshow test statistic(P = 0.841) demonstrated good calibration of the radiomics-based model. The decision curve analysis showed that patients would benefit more from a radiomics-based prediction model than from a clinical prediction model and radiomics signature alone.CONCLUSION A radiomics-based model of preoperative gadoxetic acid–enhanced MRI can be used to predict liver failure in cirrhotic patients with HCC after major hepatectomy.展开更多
HZSM-11 zeolite supported Zn catalysts with different Zn contents(xZn/HZSM-11A) were prepared. In the alkylation of benzene with dimethyl ether(DME) in a fixed bed reactor, the catalyst with Zn content of 6 wt%(6Zn/HZ...HZSM-11 zeolite supported Zn catalysts with different Zn contents(xZn/HZSM-11A) were prepared. In the alkylation of benzene with dimethyl ether(DME) in a fixed bed reactor, the catalyst with Zn content of 6 wt%(6Zn/HZSM-11A) showed appropriate performance. Focus was put on the comparison between 6Zn/HZSM-5 and 6Zn/HZSM-11 with the same crystal size of 600–800 nm, and also with the similar BET surface area, micropore volume, Si/Al2 molar ratio, and acidity. In the alkylation of benzene with DME, the 6Zn/HZSM-11 showed better activity and stability, and especially enhanced the conversion of benzene and selectivities to xylene and trimethylbenzene, compared with the6Zn/HZSM-5. This was mainly related to the higher adsorption capacity and adsorption-desorption rates to the three adsorbates(benzene,m-xylene and 1,3,5-trimethylbenzene) over the 6Zn/HZSM-11 in comparison with the 6Zn/HZSM-5.展开更多
Directional motion of dust particles in a dusty plasma ratchet is observed experimentally.The dusty plasma ratchet consists of two concentric gears with asymmetric sawtooth.It is found that the sawtooth number affects...Directional motion of dust particles in a dusty plasma ratchet is observed experimentally.The dusty plasma ratchet consists of two concentric gears with asymmetric sawtooth.It is found that the sawtooth number affects the directional motion of dust particles along the saw channel.With the increase of the sawtooth number,the particle velocity increases firstly and then decreases,and there is an optimum number of the sawtooth which could induce fast rotation of dust particles.The velocities of dust particles change as they are flowing along the saw channel.We also explore the force acting on the dust particle experimentally.展开更多
In order to observe CO_2 characteristics in the unsaturated zone of loess tableland and further understand the carbon cycle,a series of tubes for gas monitoring and sampling were installed in an approximately 90-m dee...In order to observe CO_2 characteristics in the unsaturated zone of loess tableland and further understand the carbon cycle,a series of tubes for gas monitoring and sampling were installed in an approximately 90-m deep Qiushe loess section of Lingtai County,Northwestern China.The results show that the concentration of CO_2 was higher in loess than in the atmosphere,reaching a maximum of 6970 lmol·mol^(-1).CO_2 concentrations in loess were higher in summer than in winter.The CO_2 in loess was related to organic carbon decomposed by microbes,and to the CaCO_3–H_2O–CO_2 system in the interface between the saturated and unsaturated zones.展开更多
There is a steep increase in data encoded as symmetric positive definite(SPD)matrix in the past decade.The set of SPD matrices forms a Riemannian manifold that constitutes a half convex cone in the vector space of mat...There is a steep increase in data encoded as symmetric positive definite(SPD)matrix in the past decade.The set of SPD matrices forms a Riemannian manifold that constitutes a half convex cone in the vector space of matrices,which we sometimes call SPD manifold.One of the fundamental problems in the application of SPD manifold is to find the nearest neighbor of a queried SPD matrix.Hashing is a popular method that can be used for the nearest neighbor search.However,hashing cannot be directly applied to SPD manifold due to its non-Euclidean intrinsic geometry.Inspired by the idea of kernel trick,a new hashing scheme for SPD manifold by random projection and quantization in expanded data space is proposed in this paper.Experimental results in large scale nearduplicate image detection show the effectiveness and efficiency of the proposed method.展开更多
Introduction:Transcatheter aortic valve replacement(TAVR)can have some fatal complications during and after the operation.Until recently,pre-procedural imaging with cardiac computed tomography(CT),which is required to...Introduction:Transcatheter aortic valve replacement(TAVR)can have some fatal complications during and after the operation.Until recently,pre-procedural imaging with cardiac computed tomography(CT),which is required to evaluate for TAVR,had its own imperfections.We aimed to determine whether 3 D printed models can predict complications when other pre-procedural imaging techniques failed.Methods:Vascular center patients with aortic valve stenosis,who died after TAVR between June 2011 and June2016,were enrolled in this retrospective study.The CT datasets of the patients were imported into a threedimensional(3 D)construction software and then printed by flexible material.To predict complications during and after operations,we designed a release test using the non-valved stent mode that was consistent with the Edwards Sapien XT valve in size and radial support force.Result:The 3 D model predicted the coronary obstruction and annular rupture in the in vitro release process,which was consistent with what happened in the actual operation.Conclusion:Three-dimensional modeling facilitates pre-operative assessment of patients receiving TAVR,with accurate simulation of intraoperative status.展开更多
Fish populations have declined in many estuarine and freshwater ecosystems in part due to the loss of habitat in recent decades.Reconstructing lost habitat for larvae fish is a potential method for recovering larvae f...Fish populations have declined in many estuarine and freshwater ecosystems in part due to the loss of habitat in recent decades.Reconstructing lost habitat for larvae fish is a potential method for recovering larvae fish populations.Three-dimensional artificial floating wetlands(AFWs)on which Phragmites australis was planted were experimentally deployed to recover the lost habitat in the Changjiang(Yangtze)River estuary from May to July 2018.The AFW area was characterized by slow velocity,high transparency,low dissolved oxygen,and relatively constant water temperature.The total individuals of larvae fish in the AFW area(12122 in total)was higher than that in the non-AFW area(1250 in total),and the densities of most larvae fish species were higher in the AFW habitat than in the non-AFW area.The distributions of larvae fish species were positively influenced by habitat type because they were strongly related to the negative part of the first axis of the redundancy analysis,and Cyprinus carpio and Cyprinus auratus were inclined to habitat in the slow velocity and high transparency AFW habitat area.These results indicate that larvae fish species are inclined to inhabit the AFW habitat.The use of three-dimensional P.australis AFWs would be a potential method for enhancing the habitat of larvae fish in the degraded habitats along the estuary.展开更多
Rice-fish integrated farming( RFIF) can change the agricultural production pattern from mono-farming model to the co-farming model,and the stereoscopic and integrated farming system established by RFIF can change the ...Rice-fish integrated farming( RFIF) can change the agricultural production pattern from mono-farming model to the co-farming model,and the stereoscopic and integrated farming system established by RFIF can change the flat production to the stereoscopic production. Therefore,RFIF is the important development direction for agriculture to change pattern and adjust structure. In order to further promote development of the research and application of RFIF,the general development situation of RFIF in China was reviewed; the effects of RFIF on increasing farmer' income and enhancing agricultural efficiency were clarified. The technologies matched with RFIF,such as rice paddy engineering technology,safe plant protection technology,security fertilization technology,fish disease prevention and control technology and water quality management technology,were summarized,and the supporting role of RFIF for agriculture was pointed out. In addition,the development prospect of RFIF was proposed,as well as the key research direction of RFIF.展开更多
Soils of the Chinese Loess Plateau(CLP)contain substantial amounts of soil inorganic carbon(SIC),as well as recent and ancient soil organic carbon(SOC).With the advent of the Anthropocene,human perturbation,including ...Soils of the Chinese Loess Plateau(CLP)contain substantial amounts of soil inorganic carbon(SIC),as well as recent and ancient soil organic carbon(SOC).With the advent of the Anthropocene,human perturbation,including excavation,has increased soil CO_(2) emission from the huge loess carbon pool.This study aims to determine the potential of loess CO_(2) emission induced by excavation.Soil CO_(2) were continuously monitored for seven years on a newly-excavated profile in the central CLP and the stable C isotope compositions of soil CO_(2) and SOC were used to identify their sources.The results showed that the soil CO_(2) concentrations ranged from 830μL·L^(-1) to 11190μL·L^(-1) with an annually reducing trend after excavation,indicating that the human excavation can induce CO_(2) production in loess profile.Theδ^(13) C of CO_(2) ranged from–21.27‰to–19.22‰(mean:–20.11‰),with positive deviation from top to bottom.The range of δ^(13)CSOC was–24.0‰to–21.1‰with an average of–23.1‰.Theδ^(13) C-CO_(2) in this study has a positive relationship with the reversed CO_(2) concentration,and it is calculated that 80.22%of the soil CO_(2) in this profile is from the microbial decomposition of SOC and 19.78%from the degasification during carbonate precipitation.We conclude that the human excavation can significantly enhance the decomposition of the ancient OC in loess during the first two years after perturbation,producing and releasing soil CO_(2) to atmosphere.展开更多
Objective:To systematically review the effect of Sacubitril valsartan combined with Qiliqiangxincapsule on clinical effect,serological index,cardiac function,quality of live,and adverse reactions in patients with hear...Objective:To systematically review the effect of Sacubitril valsartan combined with Qiliqiangxincapsule on clinical effect,serological index,cardiac function,quality of live,and adverse reactions in patients with heart failure.Methods:Search the databases of CNKI,VIP,WanFang,CBM,DuXiu,ChiCTR,Web of science,The Cochrane Library,PubMed and Embase to collect the randomized controlled trial(RCT)of Sacubitril valsartan combined with Qiliqiangxin capsule in the treatment of patients with heart failure,The search time limit is from the establishment of the database to May 2021.After the literatures were screened,evaluated and extracted by two researchers independently,Meta analysis was carried out with Stata 16.1 software.Results:A total of 18 RCTs,were included,including 1613 patients.The results of the Meta-analysis showed that there was statistical significance in improving the effective rate(OR=2.60,95%CI[2.09,3.24],P<0.00001),N-terminal pro-brain natriuretic peptide(MD=-468.36,95%CI[-606.80,-329.92],P<0.00001),left ventricular ejection fraction(MD=5.41,95%CI[4.93,5.89],P<0.00001),left ventricular end-diastolic diameter(MD=-3.27,95%CI[-3.65,-2.90],P<0.00001),left ventricular end-systolic diameter(MD=-3.60,95%CI[-4.99,-2.21],P<0.00001),6-minute walking distance(MD=61.42,95%CI[50.04,72.80],P<0.00001),Minnesota living with heart failure questionnaire(MD=-11.39,95%CI[-14.50,-8.28],P<0.00001),and traditional Chinese medicine syndrome score scale(MD=-3.62,95%CI[-6.45,-0.80],P=0.01),but there was no significant difference in cardiac output(MD=0.26,95%CI[-0.02,0.54],P=0.07)and adverse reactions.Conclusion:The current evidence shows that Sacubitril Valsartan combined with Qiliqiangxin capsule can better improve cardiac function,TCM symptoms and quality of life in patients with heart failure than simple Sacubitril Valsartan.However,there was no significantdifference in improving cardiac output between the two groups.However,higher quality RCTs are needed to verify.展开更多
We carried out observations toward the giant molecular cloud W 37 with the J = 1- 0 transitions of^(12) CO,^(13)CO and C^(18)O using the 13.7 m single-dish telescope at the Delingha station of Purple Mountain Observat...We carried out observations toward the giant molecular cloud W 37 with the J = 1- 0 transitions of^(12) CO,^(13)CO and C^(18)O using the 13.7 m single-dish telescope at the Delingha station of Purple Mountain Observatory. Based on these CO lines, we calculated the column densities and cloud masses for molecular clouds with radial velocities around +20 km s^(-1). The gas mass of W 37, calculated from^(13)CO emission,is 1.7 × 10~5M⊙, above the criterion to be considered a giant molecular cloud. The dense ridge of W 37 is a dense filament, which is supercritical in terms of linear mass ratio. Dense clumps found by C^(18)O emission are aligned along the dense ridge at regular intervals of about 2.8 pc, similar to the clump separation caused by large-scale ‘sausage instability'. We confirm the identification of the giant molecular filament(GMF)G 18.0–16.8 and find a new giant filament, G 16.5–15.8, located ~ 0.7?to the west of G 18.0–16.8. Both GMFs are not gravitationally bound, as indicated by their low linear mass ratio(~ 80 Mpc^(-1)⊙). We compared the gas temperature map with the dust temperature map from Herschel images, and found similar structures. The spatial distributions of class I objects and the dense clumps are reminiscent of triggered star formation occurring in the northwestern part of W 37, which is close to NGC 6611.展开更多
We present an experiment of observing the geometric phase in a superconducting circuit where the resonator and the qutrit energy levels are dispersively coupled. The drive applied to the resonator displaces its state ...We present an experiment of observing the geometric phase in a superconducting circuit where the resonator and the qutrit energy levels are dispersively coupled. The drive applied to the resonator displaces its state components associated with the qutrit's ground state and first-excited state along different circular trajectories in phase space. We identify the resonator's phase-space trajectories by Wigner tomography using an ancilla qubit, following which we observe the difference between the geometric phases associated with these trajectories using Ramsey interferometry. This geometric phase is further used to construct the single-qubit π-phase gate with a process fidelity of 0.851 ± 0.001.展开更多
Cordierite(Mg2 Al4 Si5 O18) is known for its good thermal shock resistance and it is widely used to improve thermal shock properties of materials. We found that cordierite has good infrared heat dissipation performanc...Cordierite(Mg2 Al4 Si5 O18) is known for its good thermal shock resistance and it is widely used to improve thermal shock properties of materials. We found that cordierite has good infrared heat dissipation performance. This performance provides an additional means of heat dissipation to assist in the cooling of the metal surface. Spectroscopic tests show that cordierite reflects sunlight in the visible range and emits infrared in the far infrared range, making it potential candidate as an infrared radiative cooling material for daytime use.展开更多
基金supported by the Outstanding Youth Team Project of Central Universities(QNTD202308)the Ant Group through CCF-Ant Research Fund(CCF-AFSG 769498 RF20220214).
文摘Named Entity Recognition(NER)stands as a fundamental task within the field of biomedical text mining,aiming to extract specific types of entities such as genes,proteins,and diseases from complex biomedical texts and categorize them into predefined entity types.This process can provide basic support for the automatic construction of knowledge bases.In contrast to general texts,biomedical texts frequently contain numerous nested entities and local dependencies among these entities,presenting significant challenges to prevailing NER models.To address these issues,we propose a novel Chinese nested biomedical NER model based on RoBERTa and Global Pointer(RoBGP).Our model initially utilizes the RoBERTa-wwm-ext-large pretrained language model to dynamically generate word-level initial vectors.It then incorporates a Bidirectional Long Short-Term Memory network for capturing bidirectional semantic information,effectively addressing the issue of long-distance dependencies.Furthermore,the Global Pointer model is employed to comprehensively recognize all nested entities in the text.We conduct extensive experiments on the Chinese medical dataset CMeEE and the results demonstrate the superior performance of RoBGP over several baseline models.This research confirms the effectiveness of RoBGP in Chinese biomedical NER,providing reliable technical support for biomedical information extraction and knowledge base construction.
基金supported by the National Natural Science Foundation of China (U21A20148, 31900506, 52007185)International Partnership Program of the Chinese Academy of Sciences(116134KYSB20210052)+2 种基金Heye Health Technology Chong Ming Project(HYCMP2021010)CAS President’s International Fellowship Initiative Grant(2022VMA0009)CASHIPS Director’s Fund (BJPY2021A06,2021YZGH04, YZJJ2020QN26, YZJJZX202014, YZJJ2021QN32,YZJJ2023QN43)。
文摘Although 9.4 T magnetic resonance imaging(MRI) has been tested in healthy volunteers,its safety in diabetic patients is unclear.Furthermore,the effects of high static magnetic fields(SMFs),especially gradient vs.uniform fields,have not been investigated in diabetics.Here,we investigated the consequences of exposure to 1.0-9.4 T high SMFs of different gradients(>10 T/m vs.0-10 T/m)on type 1 diabetic(T1D) and type 2 diabetic(T2D) mice.We found that 14 h of prolonged treatment of gradient(as high as 55.5 T/m) high SMFs(1.0-8.6 T) had negative effects on T1D and T2D mice,including spleen,hepatic,and renal tissue impairment and elevated glycosylated serum protein,blood glucose,inflammation,and anxiety,while 9.4 T quasi-uniform SMFs at 0-10 T/m did not induce the same effects.In regular T1D mice(blood glucose>16.7 mmol/L),the>10 T/m gradient high SMFs increased malondialdehyde(P<0.01) and decreased superoxide dismutase(P<0.05).However,in the severe T1D mice(blood glucose≥30.0 mmol/L),the>10 T/m gradient high SMFs significantly increased tissue damage and reduced survival rate.In vitro cellular studies showed that gradient high SMFs increased cellular reactive oxygen species and apoptosis and reduced MS-1 cell number and proliferation.Therefore,this study showed that prolonged exposure to high-field(1.0-8.6 T)>10 T/m gradient SMFs(35-1 380 times higher than that of current clinical MRI)can have negative effects on diabetic mice,especially mice with severe T1D,whereas 9.4 T high SMFs at 0-10T/m did not produce the same effects,providing important information for the future development and clinical application of SMFs,especially high-field MRI.
基金jointly funded by National Natural Science Foundation of China (41877398)project of the China Geological Survey (DD20221773)。
文摘Heavy metal distribution in mining areas has always been a hot research topic due to the special environment of these areas. This study aims to explore the impact of heavy metal pollution on soils and crops in the study area, ensure the safety of local crops and the health of local residents, and provide a basis for the subsequent environmental restoration and the prevention and control of environmental pollution. Based on the analysis of the heavy metal concentrations in local soils and crops, the study investigated the spatial distribution, pollution degrees, and potential ecological risks of heavy metals in the farmland of a mining area in the southeastern Nanyang Basin, Henan province, China explored the sources of heavy metals and assessed the health risks caused by crop intake. The results of this study are as follows. The root soils of crops in the study area suffered heavy metal pollution to varying degrees. The degree of heavy metal pollution in maize fields is higher than that in wheat fields, and both types of fields suffer the most severe Cd pollution. Moreover, the root soils of different crops suffer compound pollution.The root soils in the maize fields suffer severe compound pollution at some sampling positions, whose distribution is similar to that of the mining area. Cd poses the highest potential ecological risks among all heavy metals, and the study area mainly suffers low and moderate comprehensive potential ecological risks. The principal component analysis(PCA) shows that the distribution of Zn, Cd, Pb, and As in soils of the study area is mainly affected by anthropogenic factors such as local mining activities;the distribution of Cr and Ni is primarily controlled by the local geological background;the distribution of Hg is mainly affected by local vehicle exhaust emissions, and the distribution of Cu is influenced by both human activities and the geological background. Different cereal crops in the study area are polluted with heavy metals dominated by Cd and Ni to varying degrees, especially wheat. As indicated by the health risk assessment results, the intake of maize in the study area does not pose significant human health risks;however, Cu has high risks to human health, and the compound heavy metal pollution caused by the intake of wheat in the study area poses risks to the health of both adults and children. Overall, the soils and crops in the study area suffer a high degree of heavy metal pollution, for which mining activities may be the main reason.
基金Supported by the National Key R&D Program of China (No.2021YFC3001000)the National Natural Science Foundation of China (Nos.U1911204,51861125203)。
文摘Relationship between sea level change and a single climate indicator has been widely discussed.However,few studies focused on the relationship between monthly mean sea level(MMSL)and several key impact factors,including CO_(2) concentration,sea ice area,and sunspots,on various time scales.In addition,research on the independent relationship between climate factors and sea level on various time scales is lacking,especially when the dependence of climate factors on Nino 3.4 is excluded.Based on this,we use wavelet coherence(WC)and partial wavelet coherence(PWC)to establish a relationship between MMSL and its influencing factors.The WC results show that the influence of climate indices on MMSL has strong regional characteristics.The significant correlation between Southern Hemisphere sea ice area and MMSL is opposite to that between Northern Hemisphere sea ice area and MMSL.The PWC results show that after removing the influence of Nino 3.4,the significant coherent regions of the Pacific Decadal Oscillation(PDO),Dipole Mode Index(DMI),Atlantic Multidecadal Oscillation(AMO),and Southern Oscillation Index(SOI)decrease to varying degrees on different time scales in different regions,demonstrating the influence of Nino 3.4.Our work emphasizes the interrelationship and independent relationship between MMSL and its influencing factors on various time scales and the use of PWC and WC to describe this relationship.The study has an important reference significance for selecting the best predictors of sea level change or climate systems.
基金the National Natural Science Foundation of China(Grants Nos.92065204,12075128,T2225008,12174342,12274368,12274367,U20A2076,and 11725419)the Innovation Program for Quantum Science and Technology(Grant No.2021ZD0300200)+2 种基金the Zhejiang Province Key Research and Development Program(Grant No.2020C01019)supported by Tsinghua Universitythe Shanghai Qi Zhi Institute。
文摘Non-Abelian anyons are exotic quasiparticle excitations hosted by certain topological phases of matter.They break the fermion-boson dichotomy and obey non-Abelian braiding statistics:their interchanges yield unitary operations,rather than merely a phase factor,in a space spanned by topologically degenerate wavefunctions.They are the building blocks of topological quantum computing.However,experimental observation of non-Abelian anyons and their characterizing braiding statistics is notoriously challenging and has remained elusive hitherto,in spite of various theoretical proposals.Here,we report an experimental quantum digital simulation of projective non-Abelian anyons and their braiding statistics with up to 68 programmable superconducting qubits arranged on a two-dimensional lattice.By implementing the ground states of the toric-code model with twists through quantum circuits,we demonstrate that twists exchange electric and magnetic charges and behave as a particular type of non-Abelian anyons,i.e.,the Ising anyons.In particular,we show experimentally that these twists follow the fusion rules and non-Abelian braiding statistics of the Ising type,and can be explored to encode topological logical qubits.Furthermore,we demonstrate how to implement both single-and two-qubit logic gates through applying a sequence of elementary Pauli gates on the underlying physical qubits.Our results demonstrate a versatile quantum digital approach for simulating non-Abelian anyons,offering a new lens into the study of such peculiar quasiparticles.
基金the Guangdong Province Universities and Colleges Pearl River Scholar Funded Scheme(2017)the Guangdong Natural Science Foundation,No.2017A030313777。
文摘BACKGROUND Postoperative liver failure is the most severe complication in cirrhotic patients with hepatocellular carcinoma(HCC) after major hepatectomy. Current available clinical indexes predicting postoperative residual liver function are not sufficiently accurate.AIM To determine a radiomics model based on preoperative gadoxetic acid-enhanced magnetic resonance imaging for predicting liver failure in cirrhotic patients with HCC after major hepatectomy.METHODS For this retrospective study, a radiomics-based model was developed based on preoperative hepatobiliary phase gadoxetic acid-enhanced magnetic resonance images in 101 patients with HCC between June 2012 and June 2018. Sixty-one radiomic features were extracted from hepatobiliary phase images and selected by the least absolute shrinkage and selection operator method to construct a radiomics signature. A clinical prediction model, and radiomics-based model incorporating significant clinical indexes and radiomics signature were built using multivariable logistic regression analysis. The integrated radiomics-based model was presented as a radiomics nomogram. The performances of clinical prediction model, radiomics signature, and radiomics-based model for predicting post-operative liver failure were determined using receiver operating characteristics curve, calibration curve, and decision curve analyses.RESULTS Five radiomics features from hepatobiliary phase images were selected to construct the radiomics signature. The clinical prediction model, radiomics signature, and radiomics-based model incorporating indocyanine green clearance rate at 15 min and radiomics signature showed favorable performance for predicting postoperative liver failure(area under the curve: 0.809-0.894). The radiomics-based model achieved the highest performance for predicting liver failure(area under the curve: 0.894;95%CI: 0.823-0.964). The integrated discrimination improvement analysis showed a significant improvement in the accuracy of liver failure prediction when radiomics signature was added to the clinical prediction model(integrated discrimination improvement = 0.117, P =0.002). The calibration curve and an insignificant Hosmer-Lemeshow test statistic(P = 0.841) demonstrated good calibration of the radiomics-based model. The decision curve analysis showed that patients would benefit more from a radiomics-based prediction model than from a clinical prediction model and radiomics signature alone.CONCLUSION A radiomics-based model of preoperative gadoxetic acid–enhanced MRI can be used to predict liver failure in cirrhotic patients with HCC after major hepatectomy.
基金supported by the National Basic Research Program of China(No.2009CB623501)
文摘HZSM-11 zeolite supported Zn catalysts with different Zn contents(xZn/HZSM-11A) were prepared. In the alkylation of benzene with dimethyl ether(DME) in a fixed bed reactor, the catalyst with Zn content of 6 wt%(6Zn/HZSM-11A) showed appropriate performance. Focus was put on the comparison between 6Zn/HZSM-5 and 6Zn/HZSM-11 with the same crystal size of 600–800 nm, and also with the similar BET surface area, micropore volume, Si/Al2 molar ratio, and acidity. In the alkylation of benzene with DME, the 6Zn/HZSM-11 showed better activity and stability, and especially enhanced the conversion of benzene and selectivities to xylene and trimethylbenzene, compared with the6Zn/HZSM-5. This was mainly related to the higher adsorption capacity and adsorption-desorption rates to the three adsorbates(benzene,m-xylene and 1,3,5-trimethylbenzene) over the 6Zn/HZSM-11 in comparison with the 6Zn/HZSM-5.
基金Project supported by the National Natural Science Foundation of China(Grant No.11975089)the Program for National Defense Science and Technology Innovation Special Zone of Chinathe Program for Young Top-Notch Talents of Hebei Province of China.
文摘Directional motion of dust particles in a dusty plasma ratchet is observed experimentally.The dusty plasma ratchet consists of two concentric gears with asymmetric sawtooth.It is found that the sawtooth number affects the directional motion of dust particles along the saw channel.With the increase of the sawtooth number,the particle velocity increases firstly and then decreases,and there is an optimum number of the sawtooth which could induce fast rotation of dust particles.The velocities of dust particles change as they are flowing along the saw channel.We also explore the force acting on the dust particle experimentally.
基金supported jointly by National Natural Science Foundation of China(41403107,41325010)the Basic Science Research Fund from the Institute of Hydrogeology and Environmental Geology(SK201208)and the China Geological Survey Projects(12120113005900)
文摘In order to observe CO_2 characteristics in the unsaturated zone of loess tableland and further understand the carbon cycle,a series of tubes for gas monitoring and sampling were installed in an approximately 90-m deep Qiushe loess section of Lingtai County,Northwestern China.The results show that the concentration of CO_2 was higher in loess than in the atmosphere,reaching a maximum of 6970 lmol·mol^(-1).CO_2 concentrations in loess were higher in summer than in winter.The CO_2 in loess was related to organic carbon decomposed by microbes,and to the CaCO_3–H_2O–CO_2 system in the interface between the saturated and unsaturated zones.
文摘There is a steep increase in data encoded as symmetric positive definite(SPD)matrix in the past decade.The set of SPD matrices forms a Riemannian manifold that constitutes a half convex cone in the vector space of matrices,which we sometimes call SPD manifold.One of the fundamental problems in the application of SPD manifold is to find the nearest neighbor of a queried SPD matrix.Hashing is a popular method that can be used for the nearest neighbor search.However,hashing cannot be directly applied to SPD manifold due to its non-Euclidean intrinsic geometry.Inspired by the idea of kernel trick,a new hashing scheme for SPD manifold by random projection and quantization in expanded data space is proposed in this paper.Experimental results in large scale nearduplicate image detection show the effectiveness and efficiency of the proposed method.
基金funded by "Shanghai Science and Technology Commission Research Project(15411960200)".
文摘Introduction:Transcatheter aortic valve replacement(TAVR)can have some fatal complications during and after the operation.Until recently,pre-procedural imaging with cardiac computed tomography(CT),which is required to evaluate for TAVR,had its own imperfections.We aimed to determine whether 3 D printed models can predict complications when other pre-procedural imaging techniques failed.Methods:Vascular center patients with aortic valve stenosis,who died after TAVR between June 2011 and June2016,were enrolled in this retrospective study.The CT datasets of the patients were imported into a threedimensional(3 D)construction software and then printed by flexible material.To predict complications during and after operations,we designed a release test using the non-valved stent mode that was consistent with the Edwards Sapien XT valve in size and radial support force.Result:The 3 D model predicted the coronary obstruction and annular rupture in the in vitro release process,which was consistent with what happened in the actual operation.Conclusion:Three-dimensional modeling facilitates pre-operative assessment of patients receiving TAVR,with accurate simulation of intraoperative status.
基金Supported by the National Key R&D Program of China(Nos.2019YFD0901202,2018YFD0900905)the China Postdoctoral Science Foundation(No.2018M632887)。
文摘Fish populations have declined in many estuarine and freshwater ecosystems in part due to the loss of habitat in recent decades.Reconstructing lost habitat for larvae fish is a potential method for recovering larvae fish populations.Three-dimensional artificial floating wetlands(AFWs)on which Phragmites australis was planted were experimentally deployed to recover the lost habitat in the Changjiang(Yangtze)River estuary from May to July 2018.The AFW area was characterized by slow velocity,high transparency,low dissolved oxygen,and relatively constant water temperature.The total individuals of larvae fish in the AFW area(12122 in total)was higher than that in the non-AFW area(1250 in total),and the densities of most larvae fish species were higher in the AFW habitat than in the non-AFW area.The distributions of larvae fish species were positively influenced by habitat type because they were strongly related to the negative part of the first axis of the redundancy analysis,and Cyprinus carpio and Cyprinus auratus were inclined to habitat in the slow velocity and high transparency AFW habitat area.These results indicate that larvae fish species are inclined to inhabit the AFW habitat.The use of three-dimensional P.australis AFWs would be a potential method for enhancing the habitat of larvae fish in the degraded habitats along the estuary.
基金Supported by the Fundamental Research Fund of the Chinese Academy of Fishery Sciences(2016HY-ZD0701)the National Science and Technology Support Program Project(2015BAD13B03)the Special Fund of China Agriculture Research System(CARS-49)
文摘Rice-fish integrated farming( RFIF) can change the agricultural production pattern from mono-farming model to the co-farming model,and the stereoscopic and integrated farming system established by RFIF can change the flat production to the stereoscopic production. Therefore,RFIF is the important development direction for agriculture to change pattern and adjust structure. In order to further promote development of the research and application of RFIF,the general development situation of RFIF in China was reviewed; the effects of RFIF on increasing farmer' income and enhancing agricultural efficiency were clarified. The technologies matched with RFIF,such as rice paddy engineering technology,safe plant protection technology,security fertilization technology,fish disease prevention and control technology and water quality management technology,were summarized,and the supporting role of RFIF for agriculture was pointed out. In addition,the development prospect of RFIF was proposed,as well as the key research direction of RFIF.
基金funded by National Natural Science Foundation of China(Grant No.41877398)the Basic Science Research Fund from the Institute of Chinese Academy of Geological Sciences(Grant No.SK201911)the Belt and Road Fund on Water and Sustainability(U2019NKMS01)。
文摘Soils of the Chinese Loess Plateau(CLP)contain substantial amounts of soil inorganic carbon(SIC),as well as recent and ancient soil organic carbon(SOC).With the advent of the Anthropocene,human perturbation,including excavation,has increased soil CO_(2) emission from the huge loess carbon pool.This study aims to determine the potential of loess CO_(2) emission induced by excavation.Soil CO_(2) were continuously monitored for seven years on a newly-excavated profile in the central CLP and the stable C isotope compositions of soil CO_(2) and SOC were used to identify their sources.The results showed that the soil CO_(2) concentrations ranged from 830μL·L^(-1) to 11190μL·L^(-1) with an annually reducing trend after excavation,indicating that the human excavation can induce CO_(2) production in loess profile.Theδ^(13) C of CO_(2) ranged from–21.27‰to–19.22‰(mean:–20.11‰),with positive deviation from top to bottom.The range of δ^(13)CSOC was–24.0‰to–21.1‰with an average of–23.1‰.Theδ^(13) C-CO_(2) in this study has a positive relationship with the reversed CO_(2) concentration,and it is calculated that 80.22%of the soil CO_(2) in this profile is from the microbial decomposition of SOC and 19.78%from the degasification during carbonate precipitation.We conclude that the human excavation can significantly enhance the decomposition of the ancient OC in loess during the first two years after perturbation,producing and releasing soil CO_(2) to atmosphere.
文摘Objective:To systematically review the effect of Sacubitril valsartan combined with Qiliqiangxincapsule on clinical effect,serological index,cardiac function,quality of live,and adverse reactions in patients with heart failure.Methods:Search the databases of CNKI,VIP,WanFang,CBM,DuXiu,ChiCTR,Web of science,The Cochrane Library,PubMed and Embase to collect the randomized controlled trial(RCT)of Sacubitril valsartan combined with Qiliqiangxin capsule in the treatment of patients with heart failure,The search time limit is from the establishment of the database to May 2021.After the literatures were screened,evaluated and extracted by two researchers independently,Meta analysis was carried out with Stata 16.1 software.Results:A total of 18 RCTs,were included,including 1613 patients.The results of the Meta-analysis showed that there was statistical significance in improving the effective rate(OR=2.60,95%CI[2.09,3.24],P<0.00001),N-terminal pro-brain natriuretic peptide(MD=-468.36,95%CI[-606.80,-329.92],P<0.00001),left ventricular ejection fraction(MD=5.41,95%CI[4.93,5.89],P<0.00001),left ventricular end-diastolic diameter(MD=-3.27,95%CI[-3.65,-2.90],P<0.00001),left ventricular end-systolic diameter(MD=-3.60,95%CI[-4.99,-2.21],P<0.00001),6-minute walking distance(MD=61.42,95%CI[50.04,72.80],P<0.00001),Minnesota living with heart failure questionnaire(MD=-11.39,95%CI[-14.50,-8.28],P<0.00001),and traditional Chinese medicine syndrome score scale(MD=-3.62,95%CI[-6.45,-0.80],P=0.01),but there was no significant difference in cardiac output(MD=0.26,95%CI[-0.02,0.54],P=0.07)and adverse reactions.Conclusion:The current evidence shows that Sacubitril Valsartan combined with Qiliqiangxin capsule can better improve cardiac function,TCM symptoms and quality of life in patients with heart failure than simple Sacubitril Valsartan.However,there was no significantdifference in improving cardiac output between the two groups.However,higher quality RCTs are needed to verify.
基金supported by the Strategic Priority Research Program ‘The Emergence of Cosmological Structure’ of the Chinese Academy of Sciences (Grant No. XDB09000000)the Millimeter Wave Radio Astronomy Database, and the Key Laboratory for Radio Astronomy, CAS. Z.J. acknowledges the support by the National Natural Science Foundation of China (Grant No. 11233007)a joint project of the University of California, Los Angeles, and the Jet Propulsion Laboratory/California Institute of Technology, funded by the National Aeronautics and Space Administration
文摘We carried out observations toward the giant molecular cloud W 37 with the J = 1- 0 transitions of^(12) CO,^(13)CO and C^(18)O using the 13.7 m single-dish telescope at the Delingha station of Purple Mountain Observatory. Based on these CO lines, we calculated the column densities and cloud masses for molecular clouds with radial velocities around +20 km s^(-1). The gas mass of W 37, calculated from^(13)CO emission,is 1.7 × 10~5M⊙, above the criterion to be considered a giant molecular cloud. The dense ridge of W 37 is a dense filament, which is supercritical in terms of linear mass ratio. Dense clumps found by C^(18)O emission are aligned along the dense ridge at regular intervals of about 2.8 pc, similar to the clump separation caused by large-scale ‘sausage instability'. We confirm the identification of the giant molecular filament(GMF)G 18.0–16.8 and find a new giant filament, G 16.5–15.8, located ~ 0.7?to the west of G 18.0–16.8. Both GMFs are not gravitationally bound, as indicated by their low linear mass ratio(~ 80 Mpc^(-1)⊙). We compared the gas temperature map with the dust temperature map from Herschel images, and found similar structures. The spatial distributions of class I objects and the dense clumps are reminiscent of triggered star formation occurring in the northwestern part of W 37, which is close to NGC 6611.
基金Project supported by the National Basic Research Program of China(Grant No.2014CB921201)the National Natural Science Foundation of China(Grant Nos.11434008 and 11574380)
文摘We present an experiment of observing the geometric phase in a superconducting circuit where the resonator and the qutrit energy levels are dispersively coupled. The drive applied to the resonator displaces its state components associated with the qutrit's ground state and first-excited state along different circular trajectories in phase space. We identify the resonator's phase-space trajectories by Wigner tomography using an ancilla qubit, following which we observe the difference between the geometric phases associated with these trajectories using Ramsey interferometry. This geometric phase is further used to construct the single-qubit π-phase gate with a process fidelity of 0.851 ± 0.001.
基金Project supported by the National Natural Science Foundation of China(Grant Nos.51673103 and 11774189)the Shandong Provincial Key Research and Development Plan,China(Grant No.2016GGX102011)the Postdoctoral Scientific Research Foundation of Qingdao City,China(Grant No.2016014)
文摘Cordierite(Mg2 Al4 Si5 O18) is known for its good thermal shock resistance and it is widely used to improve thermal shock properties of materials. We found that cordierite has good infrared heat dissipation performance. This performance provides an additional means of heat dissipation to assist in the cooling of the metal surface. Spectroscopic tests show that cordierite reflects sunlight in the visible range and emits infrared in the far infrared range, making it potential candidate as an infrared radiative cooling material for daytime use.