Effect of laparoscopy on serum inflammatory factor, oxidative stress and immune function in patients with rectal cancer

Objective:To investigate the effect of laparoscopy on inflammatory factor, oxidative stress and immune function in patients with rectal cancer.Methods: According to random data table method, 80 cases of rectal cancer were randomly divided into the control group (n=40) and observation group (n=40), patients in the control group were given conventional open surgery and the observation group received laparoscopic surgery. The level of the serum inflammatory factor, oxidative stress and immune function before and after surgery were compared.Results:The levels of serum hs-CRP, IL-6, TNF-α, MDA, SOD, CD3+, CD4+, CD8+ and CD4+/CD8+ in the two groups before treatment were not statistically significant. The level of serum hs-CRP, IL-6 and TNF-α in the two groups were increased firstly and then decreased, which at 1 d and 3 d after operation were significantly higher than those in the same group before operation and the observation group levels were significantly higher than those in the control group at same time point. The level of serum MDA increased first and then decreased in both groups, and the level of SOD decreased firstly and then increased in two groups;the level of MDA in the two groups after 1 d and 3 d of operation were significantly higher than those before operation, and the observation group was significantly lower than the control group at the same time;the levels of SOD in the two groups after operation of 1 d and 3 d were significantly lower than those before operation, and the observation group was significantly higher than the control group at the same time. The levels of T lymphocyte: serum CD3+, CD4+ and CD4+/CD8+ in the two groups were decreased at first and then increased, which at 1 d, 3 d after operation were significantly lower than those in the same group before operation;the observation group level were significantly higher than those in the control group after 1 d and 3 d, there was statistical significant difference. The levels of serum CD8+ in the two groups were increased at first and decreased subsequently, which at 1 d and 3 d after operation were significantly higher than those in the same group before operation and the observation group levels were significantly lower than those in the control group at same time point, the difference was statistical significant.Conclusion: Compared with traditional open surgery, laparoscopic resection can reduce patient's inflammation, stress response and immune suppression, and the overall effect is better and with important clinical value.

The Melanin Biosynthesis Stimulating Compounds Isolated from the Fruiting Bodies of <i>Pleurotus citrinopileatus</i>

In the course to find a stimulating compound for melanin biosynthesis, which should be useful for a gray and a white hair-preventive agent or tanning agent, we evaluated the effects of the methanol extract from mushroom of Pleurotus citrinopileatus on melanin production in B16 melanoma cells without theophylline. Activity-guided fractionation led to isolate myo-inositol (3) and D-mannitol (4) as the stimulating compounds on melanin production in B16 melanoma cells. Also, ergosterol (1), uracil (2), and D-glucose (5) have been isolated from the methanol extract of P. citrinopileatus and showed no effect on melanin production in B16 melanoma cells. These results indicated that myo-inositol (3) and D-mannitol (4) are potential candidates that could be useful such as a gray and a white hair-preventive agent or tanning agent.

新九针火针为主治疗带状疱疹的临证体会

带状疱疹是皮肤科常见的疾病之一,该病是由于水痘-带状疱疹病毒感染所致的疱疹性皮肤病。发病时疼痛剧烈,易留有后遗神经痛等并发症,给患者带来极大痛苦,严重影响生活质量。目前临床治疗本病方法多样,然而整体疗效不太理想。笔者通过临床跟师学习发现新九针火针为主治疗本病,不仅能缩短疗程,还可降低带状疱疹后遗神经痛的发生率,提高患者生活质量,以期为带状疱疹的综合治疗提供新的思路和方法。