Traditional Chinese Medicine in colorectal cancer treatment:a bibliometrics study and visualization analysis via CiteSpace

Objective:To evaluate the current state of research and areas of interest for traditional Chinese medicine(TCM)in the field of colorectal cancer treatment.Methods:Related papers published between January 1,2012,and November 27,2021,were found using the Web of Science Core Collection Science Citation Index Expanded.Using CiteSpace's network map generation capability,we then determined the top writers,organizations,countries,keywords,co-cited writers,journals,references,and research trends.Results:This investigation yielded a total of 336 relevant papers.China is the most productive country.Shanghai University of Traditional Chinese Medicine is the leading institution.The journal with the most popularity and publishing volume is Evidence-based Complementary and Alternative Medicine.The author with the most citations and centrality is Lin JM.The terms"epithelial-mesenchymal transition,""cell cycle arrest,""apoptosis,"and"autophagy"are highly frequent and have a high betweenness centrality.Conclusion:According to the results,research on natural products,traditional Chinese medicine(TCM)extracts,and the molecular mechanisms of TCM chemical constituents constitutes the primary focus within TCM cancer treatment investigations.In recent years,there has been a surge of interest in exploring the role of gut microbiota in TCM chemical constituents research,particularly in its ability to induce apoptosis and autophagy in tumor cells,thereby suppressing tumor cell proliferation,metastasis,and invasion.However,due to the intricate composition of TCM and existing technical limitations,the underlying principles guiding TCM's efficacy in treating colorectal cancer remain unclear and warrant further investigation.

Monitoring ground temperature and deformation of the cast-in-place footings in permafrost regions on the Qinghai-Tibet Plateau

The long-term stability of the cast-in-place footings in permafrost regions has received much attention due to its climate sensitivity.The current research lacks long-term data validation,especially in the context of climate change.Based on the 13-year(2011-2023)temperature and deformation monitoring data from the Qinghai-Tibet Power Transmission Line,this study investigates the characteristics of permafrost variation and its impact on the stability of tower footings under the cooling effect from thermosyphons.The results reveal that the thermosyphons effectively reduce the ground temperature around the footings.After the first freeze-thaw cycle,the soil around the tower footings completed refreezing and maintained a frozen state.In the following 13 years,the ground temperature continued to decrease due to the cooling effect of thermosyphons.The duration notably exceeded the previously predicted 5 years.The temperature reduction at the base of the footings cor-responded well with the frost jacking of the tower footings and could be divided into three distinct phases.In phase 1,the ground temperature around the footings rapidly reduced,approaching that of the natural field,while the footings experienced pronounced deformation.In phase 2,the ground temperature decreased at a faster rate,and the deformation rate of the footings slowed down.In phase 3,the frost jacking of the footings gradually retarded with the decrease in base temperature.Additionally,the ground temperature differences of over 1 C were observed among different tower footings,which may lead to the differential deformation among the tower footings.The ground temperature differen-tiation is attributed to the difference in solar radiation intensity,which is shaded by the tower structure from different directions.This study provides theoretical support and empirical accumulation for the construction and maintenance of tower footings in permafrost regions.