Total hip arthroplasty （THA） is one of the most clinically successful surgeries. Despite the prevalence of THA, the number of revisions for septic or aseptic reasons continues to increase.
Non-syndromic hearing loss(NSHL)is a common defect in humans.Variants of MARVELD2 at the DFNB49 locus have been shown to cause bilateral,moderate to profound NSHL.However,the role of MARVELD2 in NSHL susceptibility in...Non-syndromic hearing loss(NSHL)is a common defect in humans.Variants of MARVELD2 at the DFNB49 locus have been shown to cause bilateral,moderate to profound NSHL.However,the role of MARVELD2 in NSHL susceptibility in the Chinese population has not been studied.Here we conducted a case-control study in an eastern Chinese population to profile the spectrum and frequency of MARVELD2 variants,as well as the association of MARVELD2 gene variants with NSHL.Our results showed that variants identified in the Chinese population are significantly different from those reported in Slovak,Hungarian,and Czech Roma,as well as Pakistani families.We identified 11 variants in a cohort of 283 NSHL cases.展开更多
文摘Total hip arthroplasty （THA） is one of the most clinically successful surgeries. Despite the prevalence of THA, the number of revisions for septic or aseptic reasons continues to increase.
基金Project supported by the National Basic Research Priorities Program of China(Nos.2014CB541702 and 2014CB541704)the National Natural Science Foundation of China(Nos.8147068 5?yand 81600817)the Zhejiang Provincial Public Welfare Technology Applied Research Project(No.2016C33148),China
文摘Non-syndromic hearing loss(NSHL)is a common defect in humans.Variants of MARVELD2 at the DFNB49 locus have been shown to cause bilateral,moderate to profound NSHL.However,the role of MARVELD2 in NSHL susceptibility in the Chinese population has not been studied.Here we conducted a case-control study in an eastern Chinese population to profile the spectrum and frequency of MARVELD2 variants,as well as the association of MARVELD2 gene variants with NSHL.Our results showed that variants identified in the Chinese population are significantly different from those reported in Slovak,Hungarian,and Czech Roma,as well as Pakistani families.We identified 11 variants in a cohort of 283 NSHL cases.
