The next generation of very long baseline interferometry(VLBI)is stepping into the era of microarcsecond(μas)astronomy,and pushing astronomy,especially astrometry,to new heights.VLBI with the Square Kilometre Array(S...The next generation of very long baseline interferometry(VLBI)is stepping into the era of microarcsecond(μas)astronomy,and pushing astronomy,especially astrometry,to new heights.VLBI with the Square Kilometre Array(SKA),SKA-VLBI,will increase current sensitivity by an order of magnitude,and reach astrometric precision routinely below 10μas,even challenging 1μas.This advancement allows precise parallax and proper motion measurements of various celestial objects.Such improvements can be used to study objects(including isolated objects,and binary or multiple systems)in different stellar stages(such as star formation,main-sequence stars,asymptotic giant branch stars,pulsars,black holes,white dwarfs,etc.),unveil the structure and evolution of complex systems(such as the Milky Way),benchmark the international celestial reference frame,and reveal cosmic expansion.Furthermore,the theory of general relativity can also be tested with SKA-VLBI using precise measurements of light deflection under the gravitational fields of different solar system objects and the perihelion precession of solar system objects.展开更多
Androgenetic alopecia(AGA)is a chronic and progressive form of hair loss characterized by vascular degeneration in the perifollicular microenvironment,leading to cell apoptosis and eventual loss of hair follicles(HFs)...Androgenetic alopecia(AGA)is a chronic and progressive form of hair loss characterized by vascular degeneration in the perifollicular microenvironment,leading to cell apoptosis and eventual loss of hair follicles(HFs).Traditional therapeutic formulations,such as Minoxidil(MXD)tincture,have limitations in reshaping the perifollicular microenvironment and exhibit limited effectiveness.Here,we report a multi-synergistic therapeutic platform for high-performance hair regeneration therapy.The platform combines microneedle(MN)patches loaded with MXD-encapsulated nanostructured lipid carriers(MXD-NLC-MNs)and cold atmospheric plasma(CAP).The MNs’mechanical strength enables efficient transdermal delivery of MXD to the targeted dermal papilla cells,promoting cell proliferation.Furthermore,in collaboration with MXD,the mechanical stimulation exerted by MN application synergistically upregulates the expression of vascular endothelial growth factor,leading to neoangiogenesis.Meanwhile,the transient microchannels in the skin created by MNs facilitate the transdermal delivery of CAPgenerated nitric oxide(NO)to the sites of HF lesions,whereby the synergistic interaction between MXD and NO boosts perifollicular vasodilation.Consequently,the perifollicular microenvironment can be effectively reshaped to accelerate hair regeneration in AGA murine models.This multi-synergistic combination therapy strategy would hold great promise for effectively treating AGA and promoting hair regrowth.展开更多
基金funded by the National Natural Science Foundation of China(NSFC,Grant Nos.12203104 and 11933011)the Natural Science Foundation of Jiangsu Province(grants No.BK20210999)+2 种基金the National SKA Program of China(grant No.2022SKA0120103)the Entrepreneurship and Innovation Program of Jiangsu Provincethe Key Laboratory for Radio Astronomy,CAS。
文摘The next generation of very long baseline interferometry(VLBI)is stepping into the era of microarcsecond(μas)astronomy,and pushing astronomy,especially astrometry,to new heights.VLBI with the Square Kilometre Array(SKA),SKA-VLBI,will increase current sensitivity by an order of magnitude,and reach astrometric precision routinely below 10μas,even challenging 1μas.This advancement allows precise parallax and proper motion measurements of various celestial objects.Such improvements can be used to study objects(including isolated objects,and binary or multiple systems)in different stellar stages(such as star formation,main-sequence stars,asymptotic giant branch stars,pulsars,black holes,white dwarfs,etc.),unveil the structure and evolution of complex systems(such as the Milky Way),benchmark the international celestial reference frame,and reveal cosmic expansion.Furthermore,the theory of general relativity can also be tested with SKA-VLBI using precise measurements of light deflection under the gravitational fields of different solar system objects and the perihelion precession of solar system objects.
基金supported by the National Key Research and Development Program of China(Nos.2022YFE0126000(Z.T.C.),and 2020YFA0210800(Z.W.C.))the National Natural Science Foundation of China(Nos.22277011(Z.W.C.),and 22107019(Z.W.C.))+1 种基金the Major Project of Science and Technology of Fujian Province(No.2020HZ06006(Z.W.C.))the Guangdong Basic and Applied Basic Research Foundation(No.2022A1515011129((Z.T.C.)).
文摘Androgenetic alopecia(AGA)is a chronic and progressive form of hair loss characterized by vascular degeneration in the perifollicular microenvironment,leading to cell apoptosis and eventual loss of hair follicles(HFs).Traditional therapeutic formulations,such as Minoxidil(MXD)tincture,have limitations in reshaping the perifollicular microenvironment and exhibit limited effectiveness.Here,we report a multi-synergistic therapeutic platform for high-performance hair regeneration therapy.The platform combines microneedle(MN)patches loaded with MXD-encapsulated nanostructured lipid carriers(MXD-NLC-MNs)and cold atmospheric plasma(CAP).The MNs’mechanical strength enables efficient transdermal delivery of MXD to the targeted dermal papilla cells,promoting cell proliferation.Furthermore,in collaboration with MXD,the mechanical stimulation exerted by MN application synergistically upregulates the expression of vascular endothelial growth factor,leading to neoangiogenesis.Meanwhile,the transient microchannels in the skin created by MNs facilitate the transdermal delivery of CAPgenerated nitric oxide(NO)to the sites of HF lesions,whereby the synergistic interaction between MXD and NO boosts perifollicular vasodilation.Consequently,the perifollicular microenvironment can be effectively reshaped to accelerate hair regeneration in AGA murine models.This multi-synergistic combination therapy strategy would hold great promise for effectively treating AGA and promoting hair regrowth.