It is desirable to develop a free radical generator that is neither dependent on hydrogen peroxide nor external stimuli-triggered to achieve effective tumor treatment.Herein,the free radical genera-tor MNPs-mCPBA was ...It is desirable to develop a free radical generator that is neither dependent on hydrogen peroxide nor external stimuli-triggered to achieve effective tumor treatment.Herein,the free radical genera-tor MNPs-mCPBA was constructed with Zn_(0.4)Co_(0.6)F_(e2)O_(4)@Zn_(0.4)Mn_(0.6)Fe_(2)O_(4)nanoparticles(MNPs)and 3-chloroperbenzoic acid(mCPBA).We believe that the iron(Ⅱ)on the surface of MNPs-mCPBA maybe represent high reactive activity and promote the generation of a large number of organic free radicals(C_(6)H_(4)ClCOOO)in an acidic tumor microenvironment,which realizes the acid-dependent tumor treat-ment strategy independent on the H_(2)O_(2)level in tumors.In addition,the generated organic free radicals(C_(6)H_(4)ClCOOO)effectively induced immunogenic cell death(ICD)and increased T cell infiltration.Un-der the synergetic treatment with an anti-PD-L1 antibody(α-PD-L1),a favorable anti-tumor effect was achieved.展开更多
基金supported by the National Natural Sci-ence Foundation of China(No.21877080)the Shanghai En-gineering Research Center of Green Energy Chemical Engineering(No.18DZ2254200).
文摘It is desirable to develop a free radical generator that is neither dependent on hydrogen peroxide nor external stimuli-triggered to achieve effective tumor treatment.Herein,the free radical genera-tor MNPs-mCPBA was constructed with Zn_(0.4)Co_(0.6)F_(e2)O_(4)@Zn_(0.4)Mn_(0.6)Fe_(2)O_(4)nanoparticles(MNPs)and 3-chloroperbenzoic acid(mCPBA).We believe that the iron(Ⅱ)on the surface of MNPs-mCPBA maybe represent high reactive activity and promote the generation of a large number of organic free radicals(C_(6)H_(4)ClCOOO)in an acidic tumor microenvironment,which realizes the acid-dependent tumor treat-ment strategy independent on the H_(2)O_(2)level in tumors.In addition,the generated organic free radicals(C_(6)H_(4)ClCOOO)effectively induced immunogenic cell death(ICD)and increased T cell infiltration.Un-der the synergetic treatment with an anti-PD-L1 antibody(α-PD-L1),a favorable anti-tumor effect was achieved.
