BI-D1870 Causes the Rats’ Learning and Memory Acquisition Ability Impairment

Aim: To observe the rats’ learning and memory acquisition ability disturbance induced by BI-D1870. Methods: Male SD rats were randomly divided into control group, solvent control group and BI-D1870 group. The rats in the control group were intraperitoneally injected with saline, while those in the solvent control group were intraperitoneally injected with DMSO + sulfobutyl-β-cyclodextrin solvent, and those in the BI-D1870 group were intraperitoneally injected with BI-D1870. All the rats’ appearance and behavior were daily observed, and body weight was recorded on the day 15, 30, 45, 60, 75 and 82 of BI-D1870 injected. Morris water maze was used to screen the rats’ learning and memory acquisition ability on the day 22 - 25, 52 - 55, and 82 - 85 of training by BI-D1870 treated. The successful rates of the rats’ memory impairment were respectively calculated for three times screening. Results: During the whole experiment, there was no obvious difference in appearance and fur color in all rats. The rats’ agitation began to appear on the day 10th of BI-D1870 given. The agitation rats’ number and rats’ body weight gradually increased along with BI-D1870 treated (P P Conclusion: Intraperitoneal injection of BI-D1870 can induce the rats’ learning and memory acquisition ability disorder.

Adaptive median threshold algorithm used in FDIS of DSSS receivers

For direct sequence spread spectrum （DSSS） receivers, the capability of rejecting narrow-band interference can be significantly improved by a process of frequency-domain interference suppression （FDIS）. The key issue of this process is how to determine a threshold to eliminate interference in the frequency domain, which has been extensively studied. However, these previous methods are tedious or very complex. A simple and ef- ficient algorithm based on medians is proposed. The elimination threshold is only related to the median by a scale factor, which can be obtained by the numerical analysis. Simulation results show that the algorithm provides excellent narrow-band interfer- ence suppression while only slightly degrading the signal-to-noise ratio （SNR）. A one-pass algorithm using logarithmic segmentation is further derived to estimate medians with low computational complexity. Finally, the FDIS is implemented in a field programmable gate array （FPGA） of Xilinx. Experiments are carried out by connecting the FDIS FPGA to a DSSS receiver, and the results show that the receiver has an effective countermeasure for a 60 dB interference-to-signal ratio （ISR）.

Method of adaptive PLL bandwidth adjustment without phase slipping

In a system based on the phase lock loop（PLL）, a trade-off must be made between the tracking precision and the dynamic performance if constant parameters are adopted. To overcome this drawback, a new method called no phase slipping adaptive bandwidth（NPS-AB） is proposed, which can adjust the loop bandwidth adaptively for different working conditions. As a result, both the tracking precision and the dynamic performance can be achieved concurrently. NPS-AB has two features to keep the loop stable： one is the capability of quick response to dynamics; the other is a series of additional constraints when the bandwidth is switched. Compared with other methods, there is no phase slipping during the adjustment process for NPS-AB. The phase integer ambiguity can be avoided and the phase value is kept valid. It is meaningful for carrier ranging systems. Simulation results show that NPS-AB can deal with sudden dynamics and keep the pseudo-range value stable in the entire dynamic process.

Application and improvement of wavelet packet de-noising in satellite transponder

The satellite transponder is a widely used module in satellite missions, and the most concerned issue is to reduce the noise of the transferred signal. Otherwise, the telemetry signal will be polluted by the noise contained in the transferred signal, and the additional power will be consumed. Therefore, a method based on wavelet packet de-noising （WPD） is introduced. Compared with other techniques, there are two features making WPD more suit- able to be applied to satellite transponders： one is the capability to deal with time-varying signals without any priori information of the input signals; the other is the capability to reduce the noise in band, even if the noise overlaps with signals in the frequency domain, which provides a great de-noising performance especially for wideband signals. Besides, an oscillation detector and an av- eraging filter are added to decrease the partial oscillation caused by the thresholding process of WPD. Simulation results show that the proposed algorithm can reduce more noises and make less distortions of the signals than other techniques. In addition, up to 12 dB additional power consumption can be reduced at -10 dB signal-to-noise ratio （SNR）.

Waste activated sludge hydrolysis and acidification： A comparison between sodium hydroxide and steel slag addition

Alkaline treatment with steel slag and NaOH addition were investigated under different pH conditions for the fermentation of waste activated sludge. Better performance was achieved in steel slag addition scenarios for both sludge hydrolysis and acidification. More solubilization of organic matters and much production of higher VFA （volatile fatty acid） in a shorter time can be achieved at pH 10 when adjusted by steel slag. Higher enzyme activities were also observed in steel slag addition scenarios under the same pH conditions. Phosphorus concentration in the supematant increased with fermentation time and pH in NaOH addition scenarios, while in contrast most phosphorus was released and captured by steel slag simultaneously in steel slag addition scenarios. These results suggest that steel slag can be used as a substitute for NaOH in sludge alkaline treatment.

The key mediator of diabetic kidney disease:Potassium channel dysfunction

Diabetic kidney disease is a leading cause of end-stage renal disease,making it a global public health concern.The molecular mechanisms underlying diabetic kidney disease have not been elucidated due to its complex pathogenesis.Thus,exploring these mechanisms from new perspectives is the current focus of research concerning diabetic kidney disease.lon channels are important proteins that maintain the physiological functions of cells and organs.Among ion channels,potassium channels stand out,because they are the most common and important channels on eukaryotic cell surfaces and function as the basis for cell excitability.Certain potassium channel abnormalities have been found to be closely related to diabetic kid-ney disease progression and genetic susceptibility,such as KATp,Kca,Kir,and Kv.In this review,we summarized the roles of different types of potassium channels in the occurrence and devel-opment of diabetic kidney disease to discuss whether the development of DKD is due to potas-sium channel dysfunction and present new ideas for the treatment of DKD.