Endoplasmic reticulum(ER)stress is a procedure that results from increased protein release or improper ER protein folding,which is emerging as a possible driver of pathological conditions such as cancer,cardiometaboli...Endoplasmic reticulum(ER)stress is a procedure that results from increased protein release or improper ER protein folding,which is emerging as a possible driver of pathological conditions such as cancer,cardiometabolic diseases,rheumatic disease,and neurodegenerative diseases.f,2 Activating transcription factor 4(ATF4),which is considered the primary controller of the cellular reaction when subjected to external stress,3 plays a vital role in amino acid metabolism,differentiation,metastasis,angiogenesis,and stress-related oxidative resistance.展开更多
Dear Editor,Colorectal cancer(CRC)is among the most commonly diagnosed cancer and the leading cause of cancer-related death worldwide[1].Most CRCs develop from adenomas.Laterally spreading tumors(LSTs)are non-polypoid...Dear Editor,Colorectal cancer(CRC)is among the most commonly diagnosed cancer and the leading cause of cancer-related death worldwide[1].Most CRCs develop from adenomas.Laterally spreading tumors(LSTs)are non-polypoid superficial colorectal neoplasms(CRNs)that are larger than 1 cm and typically extend laterally along the luminal wall.Based on surface morphology,it can be classified into a granular or nongranular type.The pathological morphology of LST manifests only as adenoma or with cancer.Recent studies have characterized 45-79%of LSTs as high-grade intraepithelial neoplasia(HGIN)or submucosal invasion;and the risk of submucosal invasion increases with lesion size[2].Hence,LST is considered a precancerous CRC lesion.Patients with LSTs are usually asymptomatic and diagnosis typically occurs during physical examinations or screening colonoscopy.展开更多
基金supported by the China Postdoctoral Science Foundation (No.2021M691469,2022M721526)the Guangdong Basic and Applied Basic Research Foundation (China) (No.2020A1515110872,2021A1515111220,2022A1515110165)+4 种基金the Guangzhou Science and Technology Plan Project (Guangdong,China) (No.202201011554)the National Natural Science Foundation of China (No.82102925,82303366)the Key-Area Research and Development Program of Guangdong Province,China (No.2022B0303020003)the President Foundation of Nanfang Hospital,Southern Medical University (No.2020C007)the College Students'Innovative Entrepreneurial Training Plan Program (No.S202312121115).
文摘Endoplasmic reticulum(ER)stress is a procedure that results from increased protein release or improper ER protein folding,which is emerging as a possible driver of pathological conditions such as cancer,cardiometabolic diseases,rheumatic disease,and neurodegenerative diseases.f,2 Activating transcription factor 4(ATF4),which is considered the primary controller of the cellular reaction when subjected to external stress,3 plays a vital role in amino acid metabolism,differentiation,metastasis,angiogenesis,and stress-related oxidative resistance.
基金This research was mainly supported by grants from the National Nature Science Funds of China(grant no.81772964),the Special Scientific Research Fund of Public Welfare Profession of National Health and Family Plan-ning Commission(grant no.201502026)and the Guang-dong Gastrointestinal Disease Research Center(grant no.2017B020209003).
文摘Dear Editor,Colorectal cancer(CRC)is among the most commonly diagnosed cancer and the leading cause of cancer-related death worldwide[1].Most CRCs develop from adenomas.Laterally spreading tumors(LSTs)are non-polypoid superficial colorectal neoplasms(CRNs)that are larger than 1 cm and typically extend laterally along the luminal wall.Based on surface morphology,it can be classified into a granular or nongranular type.The pathological morphology of LST manifests only as adenoma or with cancer.Recent studies have characterized 45-79%of LSTs as high-grade intraepithelial neoplasia(HGIN)or submucosal invasion;and the risk of submucosal invasion increases with lesion size[2].Hence,LST is considered a precancerous CRC lesion.Patients with LSTs are usually asymptomatic and diagnosis typically occurs during physical examinations or screening colonoscopy.
