期刊文献+
共找到1篇文章
< 1 >
每页显示 20 50 100
Acrylamide induces HepG2 cell proliferation through upregulation of miR-21 expression
1
作者 Yuyu xu Pengqi Wang +2 位作者 chaoqi xu Xiaoyun Shan Qing Feng 《The Journal of Biomedical Research》 CAS CSCD 2019年第3期181-191,共11页
Acrylamide, a potential carcinogen, exists in carbohydrate-rich foods cooked at a high temperature. It has been reported that acrylamide can cause DNA damage and cytotoxicity. The present study aimed to investigate th... Acrylamide, a potential carcinogen, exists in carbohydrate-rich foods cooked at a high temperature. It has been reported that acrylamide can cause DNA damage and cytotoxicity. The present study aimed to investigate the potential mechanism of human hepatocarcinoma HepG2 cell proliferation induced by acrylamide and to explore the antagonistic effects of a natural polyphenol curcumin against acrylamide via miR-21. The results indicated that acrylamide(≤100μmol/L) significantly increased HepG2 cell proliferation and miR-21 expression. In addition, acrylamide reduced the PTEN expression in protein level, while induced the expressions of p-AKT, EGFR and cyclin D1. The PI3 K/AKT inhibitor decreased p-AKT protein expression and inhibited the proliferation of HepG2 cells. In addition, curcumin effectively reduced acrylamide-induced HepG2 cell proliferation and induced apoptosis through the expression of miR-21. In conclusion, the results showed that acrylamide increased HepG2 cell proliferation via upregulating miR-21 expression, which may be a new target for the treatment and prevention of cancer. 展开更多
关键词 ACRYLAMIDE PROLIFERATION MIR-21
下载PDF
上一页 1 下一页 到第
使用帮助 返回顶部