Normalization of ventral tegmental area structure following acupuncture in a rat model of heroin relapse

Drugs can cause obvious damage to the brain. To verify the relationship between acupuncture, neurotrophic factor expression and brain cell structural changes, this study established a rat model of heroin relapse using intramuscular injection of increasing amounts of heroin. During the detoxification period, rat models received acupuncture at Baihui （DU20） and Dazhui （DU14）. Electron microscopy demonstrated that the structure of the ventral tegmental area in heroin relapse rats gradually became normalized after acupuncture treatment. Immunohistochem- ical staining exhibited that the expression of brain-derived neurotrophic factor and glial cell line-derived neurotrophic factor increased in the ventral tegmental area following acupuncture. Moreover, the effects were similar to that of methadone, a type of medicine called an opioid. Results suggested that acupuncture at Baihui and Dazhui protected brain neurons against injury in rats with heroin relapse by promoting brain-derived neurotrophic factor and glial cell line-de-rived neurotrophic factor expression.

Adaptive augmentation of gain-scheduled controller for aerospace vehicles

This paper proposes an adaptive augmentation control design approach of the gain-scheduled controller.This extension is motivated by the need for augmentation of the baseline gainscheduled controller.The proposed approach can be utilized to design flight control systems for advanced aerospace vehicles with a large parameter variation.The flight dynamics within the flight envelope is described by a switched nonlinear system,which is essentially a switched polytopic system with uncertainties.The flight control system consists of a baseline gain-scheduled controller and a model reference adaptive augmentation controller,while the latter can recover the nominal performance of the gainscheduled controlled system under large uncertainties.By the multiple Lyapunov functions method,it is proved that the switched nonlinear system is uniformly ultimately bounded.To validate the effectiveness of the proposed approach,this approach is applied to a generic hypersonic vehicle,and the simulation results show that the system output tracks the command signal well even when large uncertainties exist.

Output Feedback Dynamic Surface Controller Design for Airbreathing Hypersonic Flight Vehicle

This paper addresses issues related to nonlinear robust output feedback controller design for a nonlinear model of airbreathing hypersonic vehicle. The control objective is to realize robust tracking of velocity and altitude in the presence of immeasurable states, uncertainties and varying flight conditions.A novel reduced order fuzzy observer is proposed to estimate the immeasurable states. Based on the information of observer and the measured states, a new robust output feedback controller combining dynamic surface theory and fuzzy logic system is proposed for airbreathing hypersonic vehicle. The closedloop system is proved to be semi-globally uniformly ultimately bounded(SUUB), and the tracking error can be made small enough by choosing proper gains of the controller, filter and observer. Simulation results from the full nonlinear vehicle model illustrate the effectiveness and good performance of the proposed control scheme.

Fault detection and optimization for networked control systems with uncertain time-varying delay

The observer-based robust fault detection filter design and optimization for networked control systems （NOSs） with uncer- tain time-varying delays are addressed. The NCSs with uncertain time-varying delays are modeled as parameter-uncertain systems by the matrix theory. Based on the model, an observer-based residual generator is constructed and the sufficient condition for the existence of the desired fault detection filter is derived in terms of the linear matrix inequality. Furthermore, a time domain opti- mization approach is proposed to improve the performance of the fault detection system. To prevent the false alarms, a new thresh- old function is established, and the solution of the optimization problem is given by using the singular value decomposition （SVD） of the matrix. A numerical example is provided to illustrate the effectiveness of the proposed approach.

Simultaneous anti-windup synthesis for linear systems subject to actuator saturation

A synthesis method for global stability and performance of input constrained linear systems, which uses a linear outputfeedback controller and a static anti-windup compensator is investigated. Different from the traditional two-step anti-windup design procedure, the proposed method synthesizes all controller parameters simultaneously. Sufficient conditions for global stability and minimizing the induced L2 gain are formulated and solved as a linear matrix inequalities（LMIs） optimization problem, which also provides an opportunity to search for a better performance tradeoff between the linear controller and the anti-windup compensator.The well-posedness of the close-loop system is also guaranteed.Simulation results show the effectiveness of the proposed method.

Asynchronous H_∞ Control for Unmanned Aerial Vehicles: Switched Polytopic System Approach

This study is concerned with the H∞control for the full-envelope unmanned aerial vehicles(UAVs) in the presence of missing measurements and external disturbances. With the dramatic parameter variations in large flight envelope and the locally overlapped switching laws in flight, the system dynamics is modeled as a locally overlapped switched polytopic system to reduce designing conservatism and solving complexity. Then,considering updating lags of controller s switching signals and the weighted coefficients of the polytopic subsystems induced by missing measurements, an asynchronous H∞control method is proposed such that the system is stable and a desired disturbance attenuation level is satisfied. Furthermore, the sufficient existing conditions of the desired switched parameter-dependent H∞controller are derived in the form of linear matrix inequality(LMIs) by combining the switched parameter-dependent Lyapunov function method and average dwell time method.Finally, a numerical example based on a highly maneuverable technology(Hi MAT) vehicle is given to verify the validity of the proposed method.

Active Disturbance Rejection Control for Uncertain Nonlinear Systems With Sporadic Measurements

This paper deals with the problem of active disturbance rejection control(ADRC)design for a class of uncertain nonlinear systems with sporadic measurements.A novel extended state observer(ESO)is designed in a cascade form consisting of a continuous time estimator,a continuous observation error predictor,and a reset compensator.The proposed ESO estimates not only the system state but also the total uncertainty,which may include the effects of the external perturbation,the parametric uncertainty,and the unknown nonlinear dynamics.Such a reset compensator,whose state is reset to zero whenever a new measurement arrives,is used to calibrate the predictor.Due to the cascade structure,the resulting error dynamics system is presented in a non-hybrid form,and accordingly,analyzed in a general sampled-data system framework.Based on the output of the ESO,a continuous ADRC law is then developed.The convergence of the resulting closed-loop system is proved under given conditions.Two numerical simulations demonstrate the effectiveness of the proposed control method.

Switched adaptive active disturbance rejection control of variable structure near space vehicles based on adaptive dynamic programming

Based on the switched nonlinear system, a switched adaptive Active Disturbance Rejection Control(ADRC) law is proposed for the Variable Structure Near Space Vehicle(VSNSV) with unknown uncertainties and external disturbances. The reduced-order Extended State Observers(ESOs) are constructed for the attitude angle system and the angular rate system to estimate the total disturbance in real time. With the extended state introduced to counteract the effects of uncertainties and disturbances, a systematic procedure is presented for the synthesis of the switched adaptive ADRC strategy. Rigorous proof shows that the estimation errors of the reduced-order ESOs would converge to a small neighborhood of zero in finite time, and that the output of the closedloop system can track a given signal stably for a class of switching signals with average dwell time via the proposed approach. The variable gain control strategy based on Adaptive Dynamic Programming(ADP) with the actor-critic structure is also designed to improve the dynamic performance of the system. Simulation results verify the effectiveness and advantage of the proposed control scheme.

Fully distributed time-varying formation tracking control for multiple quadrotor vehicles via finite-time convergent extended state observer

This paper investigates a time-varying anti-disturbance formation problem for a group of quadrotor aircrafts with time-varying uncertainties and a directed interaction topology.A novel Finite-Time Convergent Extended State Observer(FTCESO)based fully-distributed formation control scheme is proposed to enhance the disturbance rejection and the formation tracking performances for networked quadrotors.By adopting the hierarchical control strategy,the multiquadrotor system is separated into two subsystems:the outer-loop cooperative subsystem and the inner-loop attitude subsystem.In the outer-loop subsystem,with the estimation of disturbing forces and uncertain dynamics from FTCESOs,an adaptive consensus theory based cooperative controller is exploited to ensure the multiple quadrotors form and maintain a time-varying pattern relying only on the positions of the neighboring aircrafts.In the inner-loop subsystem,the desired attitude generated by the cooperative control law is stably tracked under a FTCESO-based attitude controller in a finite time.Based on a detailed algorithm to specify the cooperative control protocol,the feasibility condition to achieve the time-varying anti-disturbance formation tracking is derived and the rigorous analysis of the whole closed-loop multi-quadrotor system is given.Some numerical examples are conducted to intuitively demonstrate the effectiveness and the improvements of the proposed control framework.

Cross-Scale Synthesis of Organic High-k Semiconductors Based on Spiro-Gridized Nanopolymers

High dielectric constants in organic semiconductors have been identified as a central challenge for the improvement in not only piexoelectric,preolecric,and freeltric efcts but also photoclecric conversion eficiency in OPVs,carrier mobility in OFETS,and charge density in charge-trapping memories.Herein,we report an ultralong persistence length(≈41 nm)efet of spiro-fused organic nanopolymers on dielectric properties,together with excitonic and charge carrier behaviors.The state-of-the-art nanopolymers,namely,nanopolyspirogrids(NPSGs),are synthesized via the simple crossscale Friedel-Crafts polygridlization of AjB-type nanomonomers.The high dielectric constant(k=8.43)of NPSG is firstly achieved by locking spiro-polygridization efect that results in the enhancement of dipole polarization.When doping into a polystyrene-based dielectric layer,such a high-k feature of NPSG increases the feld-ffct carrier mobility from 0.20 to 0.90cm^(2)Vl s'in pentacene OFET devices.Meanwhile,amorphous NPSG film exhibits an ultralow energy disorder(<50 meV)for an exellent zero-field hole mobility of 3.94×10^(-1)cm^(2)V^(-1)s^(-1).surpassing most of the amorphousπconjugated polymers Onganic nanopolymers with high dielectric constants open a new way to break through the bottleneck of eficiency and multifunctionality in the blueprint of the fourth generation semiconductors.

Non-fragile switched H_∞ control for morphing aircraft with asynchronous switching

This paper deals with the problem of non-fragile linear parameter-varying（LPV） H_∞ control for morphing aircraft with asynchronous switching.The switched LPV model of morphing aircraft is established by Jacobian linearization approach according to the nonlinear model.The data missing is taken into account in the link from sensors to controllers and the link from controllers to actuators,which satisfies Bernoulli distribution.The non-fragile switched LPV controllers are constructed with consideration of the uncertainties of controllers and asynchronous switching phenomenon.The parameter-dependent Lyapunov functional method and mode-dependent average dwell time（MDADT） method are combined to guarantee the stability and prescribed performance of the system.The sufficient conditions on the solvability of the problem are derived in the form of linear matrix inequalities（LMI）.In order to achieve higher efficiency of the designing process,an algorithm is applied to divide the whole set into subsets automatically.Simulation results are provided to verify the effectiveness and superiority of the method in the paper.

Phase plane design based fast altitude tracking control for hypersonic flight vehicle with angle of attack constraint

In this paper, fast setpoint altitude tracking control for Hypersonic Flight Vehicle(HFV)satisfying Angle of Attack(AOA) constraint is studied with a two-loop structure controller, in the presence of parameter uncertainties and disturbances. For the outer loop, phase plane design is adopted for the simplified model under Bang-Bang controller to generate AOA command guaranteeing fast tracking performance. Modifications based on Feedback-Linearization(FL) technique are adopted to transform the phase trajectory into a sliding curve. Moreover, to resist mismatch between design model and actual model, Fast Exponential Reaching Law(FERL) is augmented with the baseline controller to maintain state on the sliding curve. The inner-loop controller is based on backstepping technique to track the AOA command generated by outer-loop controller. Barrier Lyapunov Function(BLF) design is employed to satisfy AOA requirement. Moreover, a novel auxiliary state is introduced to remove the restriction of BLF design on initial tracking errors. Dynamic Surface Control(DSC) is utilized to ease the computation burden. Rigorous stability proof is then given, and AOA is guaranteed to stay in predefined region theoretically. Simulations are conducted to verify the efficiency and superior performance of the proposed method.