INDUCTION OF ETHOXYRESORUFIN-O-DEETHYLASE ACTIVITY IN HUMAN SQUAMOUS CARCINOMA CELLS BY 2,3,7,8-TETRACHLORODIBENZO-p-DIOXIN(TCDD)

Induction of the activity of ethoxyresorufin-o-deethylase(EROD),one of the isozymes ofmixed function oxidase,in human squamouscarcinoma cells of the tongue(SCC-15G andSCC-25)treated with TCDD was invistigated.

四氯二苯二氧芑对人舌鳞癌细胞增生机制的研究

应用人舌鳞癌细胞株SCC-15G和SCC-25,通过单层细胞生长的细胞数和~3H-TdR掺入DNA的观察,进一步阐明了2,3,7,8-四氯二苯二氧(艹己)(TCDD)诱导刺激上皮细胞增生是由于降低了高密度生长抑制的敏感性引起的。SCC-15G细胞可作为研究TCDD对上皮细胞作用机制的理想模型。SCC-25细胞对TCDD反应较弱且不稳定,不宜用于研究上皮细胞增生机制。