Focal dermal hypoplasia (Goltz) syndrome is a rare genetic disorder characterized by cutaneous, ectodermal and meso dermal defects. We present a case in which painful, exophytic granulation tissue has been the main sy...Focal dermal hypoplasia (Goltz) syndrome is a rare genetic disorder characterized by cutaneous, ectodermal and meso dermal defects. We present a case in which painful, exophytic granulation tissue has been the main symptom over the past 15 years. After unsatisfactory results with a number of treatment modalities including topical steroids, silver-nitrate applications, cryotherapy, curettage, excision and pulsed-dye laser, we achieved significant benefit with curettage in combination with photodynamic therapy. Although impaired wound healing has been described in focal dermal hypoplasia, this is, to our knowledge, the first time that pyogenic granuloma-like lesions have been reported.展开更多
Subacute cutaneous lupus erythematosus (SCLE) is characterized by clinical, laboratory and immunological features different from those of systemic lupus erythematosus (SLE). We describe the case of a patient with a 2-...Subacute cutaneous lupus erythematosus (SCLE) is characterized by clinical, laboratory and immunological features different from those of systemic lupus erythematosus (SLE). We describe the case of a patient with a 2- year history of SCLE that demonstrated a close temporal relationship with a squamous cell malignancy of the head and neck. This association has not been previously reported. We also review the evidence for SCLE as a ‘ paraneoplastic dermatosis’ and discuss the criteria for diagnosis and possible pathogenesis.展开更多
Lichen sclerosus(LS)is a chronic cutaneous disorder of uncertain aetiology seen predominantly in females.It is characterized by white atrophic macules and plaques with a predilection for involvement of the genitalia a...Lichen sclerosus(LS)is a chronic cutaneous disorder of uncertain aetiology seen predominantly in females.It is characterized by white atrophic macules and plaques with a predilection for involvement of the genitalia and perianal skin.Gender-identity disorder(transsexualism)is a descriptive term for individual shaving the genetic,somatic and hormonal basis of one sex but who identify sexually with the opposite sex.Surgical gender reassignment is a fundamental step in the management of these complex patients and is driven by the individual’s belief of being the opposite sex ’trapped’in the wrong body.We report a case of genital lichen sclerosus in hair-bearing skin originally from the scrotum,in an individual who had undergone maleto-female gender reassignment.To our knowledge,no similar cases have been reported to date.展开更多
文摘Focal dermal hypoplasia (Goltz) syndrome is a rare genetic disorder characterized by cutaneous, ectodermal and meso dermal defects. We present a case in which painful, exophytic granulation tissue has been the main symptom over the past 15 years. After unsatisfactory results with a number of treatment modalities including topical steroids, silver-nitrate applications, cryotherapy, curettage, excision and pulsed-dye laser, we achieved significant benefit with curettage in combination with photodynamic therapy. Although impaired wound healing has been described in focal dermal hypoplasia, this is, to our knowledge, the first time that pyogenic granuloma-like lesions have been reported.
文摘Subacute cutaneous lupus erythematosus (SCLE) is characterized by clinical, laboratory and immunological features different from those of systemic lupus erythematosus (SLE). We describe the case of a patient with a 2- year history of SCLE that demonstrated a close temporal relationship with a squamous cell malignancy of the head and neck. This association has not been previously reported. We also review the evidence for SCLE as a ‘ paraneoplastic dermatosis’ and discuss the criteria for diagnosis and possible pathogenesis.
文摘Lichen sclerosus(LS)is a chronic cutaneous disorder of uncertain aetiology seen predominantly in females.It is characterized by white atrophic macules and plaques with a predilection for involvement of the genitalia and perianal skin.Gender-identity disorder(transsexualism)is a descriptive term for individual shaving the genetic,somatic and hormonal basis of one sex but who identify sexually with the opposite sex.Surgical gender reassignment is a fundamental step in the management of these complex patients and is driven by the individual’s belief of being the opposite sex ’trapped’in the wrong body.We report a case of genital lichen sclerosus in hair-bearing skin originally from the scrotum,in an individual who had undergone maleto-female gender reassignment.To our knowledge,no similar cases have been reported to date.
