The advent of synthetic biology has ushered in new applications of cell-free transcription-translation systems. These cell-free systems are reconstituted using cellular proteins, and are amenable to modular control of...The advent of synthetic biology has ushered in new applications of cell-free transcription-translation systems. These cell-free systems are reconstituted using cellular proteins, and are amenable to modular control of their composition. Here, we discuss the historical advance- ment of cell-free systems, as well as their new applications in the rapid design of synthetic genetic circuits and components, directed evolution ofbiomolecules, diagnosis of infectious diseases, and synthesis of vaccines. Finally, we present our vision on the future direction of cell-free synthetic biology.展开更多
Over the past 15 years, the field of synthetic biology has seen a rapid rise in research activities and innovation, as evident by the increase of publications that quote the term ＂synthetic biology＂ from one in 2002...Over the past 15 years, the field of synthetic biology has seen a rapid rise in research activities and innovation, as evident by the increase of publications that quote the term ＂synthetic biology＂ from one in 2002 to -1400 in 2016 （from PubMed）.展开更多
文摘The advent of synthetic biology has ushered in new applications of cell-free transcription-translation systems. These cell-free systems are reconstituted using cellular proteins, and are amenable to modular control of their composition. Here, we discuss the historical advance- ment of cell-free systems, as well as their new applications in the rapid design of synthetic genetic circuits and components, directed evolution ofbiomolecules, diagnosis of infectious diseases, and synthesis of vaccines. Finally, we present our vision on the future direction of cell-free synthetic biology.
文摘Over the past 15 years, the field of synthetic biology has seen a rapid rise in research activities and innovation, as evident by the increase of publications that quote the term ＂synthetic biology＂ from one in 2002 to -1400 in 2016 （from PubMed）.
