目的:探讨基于可变形图像配准(deformableregistration algorithms,DRA)算法的心肌形变分析在肥厚型心肌病(hypertrophic cardiomyopathy,HCM)中的诊断及预后预测价值。方法:回顾性收集本院确诊的HCM患者23例,另招募23名年龄性别匹配的...目的:探讨基于可变形图像配准(deformableregistration algorithms,DRA)算法的心肌形变分析在肥厚型心肌病(hypertrophic cardiomyopathy,HCM)中的诊断及预后预测价值。方法:回顾性收集本院确诊的HCM患者23例,另招募23名年龄性别匹配的健康志愿者(对照组),均行心脏MRI扫描。HCM组按有无心肌延迟强化(late gadolinium enhancement,LGE)分为LGE(+)组和LGE(-)组。采用基于DRA算法的TrufiStrain软件进行心肌形变分析,测量整体径向应变峰值(global peak radial strain, GPRS)、整体环向应变峰值(global peak circumferential strain, GPCS)和整体纵向应变峰值(global peak longitudinal strain, GPLS)以及心尖部、中部和基底部的径向应变峰值(peak radial strain, PRS)、环向应变峰值(peak circumferential strain, PCS)和纵向应变峰值(peak longitudinal strain,PLS),探讨心肌形变参数在HCM中的诊断效能及其与心室壁厚度、LGE间的关系。结果:除心尖部PCS外,HCM组的GPRS、GPCS、GPLS及基底部和中部PRS、PCS、PLS,以及心尖部的PRS、PLS均明显低于对照组(P<0.05),而HCM组的整体及各部分3个方向(环向、纵向、径向)的应变率比值均明显小于对照组(P<0.05),且LGE(-)组及对照组各部分的PRS、PCS、PLS及3个方向的舒张早期和晚期应变率比值[径向应变率比值(ratio of radial strain rate during early and late diastole,REL),环向应变率比值(ratio of circumferential strain rate during early and late diastole,CEL)和纵向应变率比值(ratio of longitudinal strain rate during early and late diastole,LEL)]均大于LGE(+)组(P<0.05)。GPRS、GPCS、GPLS、REL、CEL、LEL均与左心室心肌最大厚度明显相关(P<0.05)。GPRS、GPCS、GPLS、REL、CEL及LEL诊断HCM的曲线下面积分别为0.686、0.905、0.921、0.972、0.974及0.917,GPRS、GPCS、GPLS、REL、CEL及LEL预测HCM患者是否有LGE的曲线下面积均大于0.871。结论:基于DRA的心肌形变分析在诊断HCM、预测HCM患者发生LGE中具有重要价值,且与心肌厚度密切相关。展开更多
Tujia Language is an endangered language.Language endangerment is deteriorating under the background of globalization.The preservation of endangered languages is more urgent and important than before.The best preserva...Tujia Language is an endangered language.Language endangerment is deteriorating under the background of globalization.The preservation of endangered languages is more urgent and important than before.The best preservation of the endangered languages is to study them.The language ecology and preservation problem of Tujia Language will be investigated and discussed in this paper.展开更多
文摘目的:探讨基于可变形图像配准(deformableregistration algorithms,DRA)算法的心肌形变分析在肥厚型心肌病(hypertrophic cardiomyopathy,HCM)中的诊断及预后预测价值。方法:回顾性收集本院确诊的HCM患者23例,另招募23名年龄性别匹配的健康志愿者(对照组),均行心脏MRI扫描。HCM组按有无心肌延迟强化(late gadolinium enhancement,LGE)分为LGE(+)组和LGE(-)组。采用基于DRA算法的TrufiStrain软件进行心肌形变分析,测量整体径向应变峰值(global peak radial strain, GPRS)、整体环向应变峰值(global peak circumferential strain, GPCS)和整体纵向应变峰值(global peak longitudinal strain, GPLS)以及心尖部、中部和基底部的径向应变峰值(peak radial strain, PRS)、环向应变峰值(peak circumferential strain, PCS)和纵向应变峰值(peak longitudinal strain,PLS),探讨心肌形变参数在HCM中的诊断效能及其与心室壁厚度、LGE间的关系。结果:除心尖部PCS外,HCM组的GPRS、GPCS、GPLS及基底部和中部PRS、PCS、PLS,以及心尖部的PRS、PLS均明显低于对照组(P<0.05),而HCM组的整体及各部分3个方向(环向、纵向、径向)的应变率比值均明显小于对照组(P<0.05),且LGE(-)组及对照组各部分的PRS、PCS、PLS及3个方向的舒张早期和晚期应变率比值[径向应变率比值(ratio of radial strain rate during early and late diastole,REL),环向应变率比值(ratio of circumferential strain rate during early and late diastole,CEL)和纵向应变率比值(ratio of longitudinal strain rate during early and late diastole,LEL)]均大于LGE(+)组(P<0.05)。GPRS、GPCS、GPLS、REL、CEL、LEL均与左心室心肌最大厚度明显相关(P<0.05)。GPRS、GPCS、GPLS、REL、CEL及LEL诊断HCM的曲线下面积分别为0.686、0.905、0.921、0.972、0.974及0.917,GPRS、GPCS、GPLS、REL、CEL及LEL预测HCM患者是否有LGE的曲线下面积均大于0.871。结论:基于DRA的心肌形变分析在诊断HCM、预测HCM患者发生LGE中具有重要价值,且与心肌厚度密切相关。
基金the final achievement of the social science fund program of the Hubei Provincial Department of Education(15 Q145)
文摘Tujia Language is an endangered language.Language endangerment is deteriorating under the background of globalization.The preservation of endangered languages is more urgent and important than before.The best preservation of the endangered languages is to study them.The language ecology and preservation problem of Tujia Language will be investigated and discussed in this paper.