In this paper, the effects of hyperthermia on cells and immune system are introduced briefly. The mechanism of action of hyperthermia on human papilloma virus （HPV）-infected skin diseases was elaborated as an exampl...In this paper, the effects of hyperthermia on cells and immune system are introduced briefly. The mechanism of action of hyperthermia on human papilloma virus （HPV）-infected skin diseases was elaborated as an example in this paper. Many studies have proved that hyperthermia affects a number of cellular and molecu- lar constitutes in the skin immune system, involving both innate and adaptive immune responses; the efficacy of hyperthermia in treating some infectious and cancerous conditions has been validated and applied in clinics, while molecular mechanisms of hyperthermia affecting the immunereaction is still unclear.展开更多
目的探讨DnaJA4对咪喹莫特诱导小鼠银屑病样皮肤炎症的影响。方法4组小鼠(每组8只),即应用咪喹莫特(imiquimod,IMQ)诱导银屑病样皮炎的DnaJA4敲除(knockout,KO-IMQ)组小鼠及野生型(wild-type,WT-IMQ)小鼠,涂以等量凡士林的DnaJA4敲除(kn...目的探讨DnaJA4对咪喹莫特诱导小鼠银屑病样皮肤炎症的影响。方法4组小鼠(每组8只),即应用咪喹莫特(imiquimod,IMQ)诱导银屑病样皮炎的DnaJA4敲除(knockout,KO-IMQ)组小鼠及野生型(wild-type,WT-IMQ)小鼠,涂以等量凡士林的DnaJA4敲除(knockout,KO-blank)组小鼠及野生型(wild-type,WT-blank)小鼠。银屑病皮损面积及严重程度指数(psoriasis area and severity index,PASI)评价IMQ诱导的小鼠银屑病样皮损表现。HE染色观察皮损病理特征。免疫组织化学染色观察小鼠皮损表皮IL-6、IL-17、IL-27、C-X-C型趋化因子配体1(C-X-C motif ligand 1,CXCL1)阳性程度及银屑病患者与正常对照皮肤组织内DnaJA4表达情况。结果IMQ诱导的银屑病样皮炎小鼠模型中,DnaJA4-KO小鼠出现更严重的红斑,皮肤增厚更明显,累积PASI评分在第3~5天明显高于WT小鼠,并较WT小鼠真皮更早出现炎症细胞,浸润细胞数更多,且在应用IMQ的第4天见更大面积的Munro's微脓肿。IMQ诱导的DnaJA4-KO小鼠银屑病样皮损表皮内IL-6、IL-17、CXCL1均较WT小鼠呈上调表达;DnaJA4未见于银屑病患者皮损组织,但在正常皮肤组织表皮基底细胞阳性表达。结论DnaJA4敲除通过上调表皮内促炎细胞因子及趋化因子表达加重IMQ诱导的小鼠银屑病样皮肤炎症,并影响Munro's微脓肿形成。展开更多
Suppressor of cytokine signaling 3 （SOCS3） proteins, a Pmember of SOCS family, are predominantly expressed in Th2 cells, and it has an important role in regulating the onset and maintenance of Th2-mediated allergic ...Suppressor of cytokine signaling 3 （SOCS3） proteins, a Pmember of SOCS family, are predominantly expressed in Th2 cells, and it has an important role in regulating the onset and maintenance of Th2-mediated allergic immune disease.1 SOCS can translocate from cytoplasm to nucleus when the level in cytoplasm increases, and localize to cell membrane where it binds to receptors. However, to our knowledge, there has been no documentation whether SOCS can transport to the intercellular space or circulating body fluids, let alone the subsequent biological significance. Signal transducer and activator of transcription （STAT） proteins, a group of transcription factor, are critical for mediating signals during Thl, Th2,展开更多
Oracle bone inscriptions,the earliestform of Chinese writings,were used from the Shang dynasty to the Western Zhou dynasty （1 600 BC 1 000 BC）.These inscriptions were carved on turtle shells and animal bones,which w...Oracle bone inscriptions,the earliestform of Chinese writings,were used from the Shang dynasty to the Western Zhou dynasty （1 600 BC 1 000 BC）.These inscriptions were carved on turtle shells and animal bones,which were primarily used for divination at that time.Among over 150 000 oracle bone pieces excavated,41 956pieces were collected in the book named Jia Gu Wen He Ji in Chinese （Collection and Analyses of Oracle Bone Inscriptions）.So far about 4 500 oracle bone inscriptions have been interpreted and about 2 600 have been decoded.Among those,about 1 056 oracle bone inscriptions have been widely accepted by authorities in China and abroad.1 Here we scrutinized the well-interpreted oracle bone inscriptions and selected 95 characters related to medicine and dermatology for discussion.展开更多
文摘In this paper, the effects of hyperthermia on cells and immune system are introduced briefly. The mechanism of action of hyperthermia on human papilloma virus （HPV）-infected skin diseases was elaborated as an example in this paper. Many studies have proved that hyperthermia affects a number of cellular and molecu- lar constitutes in the skin immune system, involving both innate and adaptive immune responses; the efficacy of hyperthermia in treating some infectious and cancerous conditions has been validated and applied in clinics, while molecular mechanisms of hyperthermia affecting the immunereaction is still unclear.
文摘目的探讨DnaJA4对咪喹莫特诱导小鼠银屑病样皮肤炎症的影响。方法4组小鼠(每组8只),即应用咪喹莫特(imiquimod,IMQ)诱导银屑病样皮炎的DnaJA4敲除(knockout,KO-IMQ)组小鼠及野生型(wild-type,WT-IMQ)小鼠,涂以等量凡士林的DnaJA4敲除(knockout,KO-blank)组小鼠及野生型(wild-type,WT-blank)小鼠。银屑病皮损面积及严重程度指数(psoriasis area and severity index,PASI)评价IMQ诱导的小鼠银屑病样皮损表现。HE染色观察皮损病理特征。免疫组织化学染色观察小鼠皮损表皮IL-6、IL-17、IL-27、C-X-C型趋化因子配体1(C-X-C motif ligand 1,CXCL1)阳性程度及银屑病患者与正常对照皮肤组织内DnaJA4表达情况。结果IMQ诱导的银屑病样皮炎小鼠模型中,DnaJA4-KO小鼠出现更严重的红斑,皮肤增厚更明显,累积PASI评分在第3~5天明显高于WT小鼠,并较WT小鼠真皮更早出现炎症细胞,浸润细胞数更多,且在应用IMQ的第4天见更大面积的Munro's微脓肿。IMQ诱导的DnaJA4-KO小鼠银屑病样皮损表皮内IL-6、IL-17、CXCL1均较WT小鼠呈上调表达;DnaJA4未见于银屑病患者皮损组织,但在正常皮肤组织表皮基底细胞阳性表达。结论DnaJA4敲除通过上调表皮内促炎细胞因子及趋化因子表达加重IMQ诱导的小鼠银屑病样皮肤炎症,并影响Munro's微脓肿形成。
文摘Suppressor of cytokine signaling 3 （SOCS3） proteins, a Pmember of SOCS family, are predominantly expressed in Th2 cells, and it has an important role in regulating the onset and maintenance of Th2-mediated allergic immune disease.1 SOCS can translocate from cytoplasm to nucleus when the level in cytoplasm increases, and localize to cell membrane where it binds to receptors. However, to our knowledge, there has been no documentation whether SOCS can transport to the intercellular space or circulating body fluids, let alone the subsequent biological significance. Signal transducer and activator of transcription （STAT） proteins, a group of transcription factor, are critical for mediating signals during Thl, Th2,
文摘Oracle bone inscriptions,the earliestform of Chinese writings,were used from the Shang dynasty to the Western Zhou dynasty （1 600 BC 1 000 BC）.These inscriptions were carved on turtle shells and animal bones,which were primarily used for divination at that time.Among over 150 000 oracle bone pieces excavated,41 956pieces were collected in the book named Jia Gu Wen He Ji in Chinese （Collection and Analyses of Oracle Bone Inscriptions）.So far about 4 500 oracle bone inscriptions have been interpreted and about 2 600 have been decoded.Among those,about 1 056 oracle bone inscriptions have been widely accepted by authorities in China and abroad.1 Here we scrutinized the well-interpreted oracle bone inscriptions and selected 95 characters related to medicine and dermatology for discussion.
