欧洲和北美是当前绅士化研究的主要阵地。从城市芝加哥学派到马克思主义范式,再到多元研究视角,绅士化理论的发展与欧美城市研究的发展趋势基本一致,这表明绅士化与更广泛的城市空间重构紧密联系。随着比较城市研究范式的兴起,绅士化在...欧洲和北美是当前绅士化研究的主要阵地。从城市芝加哥学派到马克思主义范式,再到多元研究视角,绅士化理论的发展与欧美城市研究的发展趋势基本一致,这表明绅士化与更广泛的城市空间重构紧密联系。随着比较城市研究范式的兴起,绅士化在全球范围的普适性引发了诸多争议。本文以Web of Science数据库收集的1716篇文献为基础,通过可视化分析和文献综述,总结了近15年来国内外绅士化研究的演进、共识和争议。与欧美发达经济体相比,中国在政府与市场作用、国家主导地位、公众参与程度、产权制度等方面都呈现一种截然不同的绅士化过程,需正确认识我国经济转型过程中绅士化的形成机制,避免负面的社会空间效应,为我国新一轮城市化注入活力。展开更多
OBJECTIVE:To explore biomarkers of Pien Tze Huang(片仔癀)that ameliorated the symptoms of hepatic fibrosis.METHODS:Two groups of carbon tetrachloride-induced hepatic fibrosis(HF)mice model were constructed in our stud...OBJECTIVE:To explore biomarkers of Pien Tze Huang(片仔癀)that ameliorated the symptoms of hepatic fibrosis.METHODS:Two groups of carbon tetrachloride-induced hepatic fibrosis(HF)mice model were constructed in our study:one group received PZH treatment and another group received no treatment.We performed this study to investigate the role of PZH in the regulation process of hepatic fibrosis.RESULTS:We identified 31 down-regulated and 39 upregulated mi RNAs using small RNA-seq analysis.Combining RNA-Seq data analysis,our study revealed 7 significant target genes(Sp4,Slc2 a6,Tln2,Hmga2,Ank3,Pax9,Fgf9).The results of real-time quantitative polymerase chain reaction analysis suggested that the expression level of 6 genes(Sp4,Tln2,Hmga2,Ank3,Pax9,Fgf9)were down-regulated compared to control group.On the other hand,the expression level of Slc2 a6 appeared to be up-regulated.The protein mass spectrometry showed that PZH group had lower protein expression of Tln2 compared to control group.CONCLUSION:We identified 7 genes that were significantly related to PZH response in HF mice using multiple conjoint analysis methods.These genes could participate in underlying regulation mechanism of hepatic fibrosis during PZH treatment.展开更多
Schizophrenia is a life-long,complex mental illness that still lacks satisfactory treatments.In recent years,increasing numbers of candidate biomarkers of schizophrenia occurrences and drug responses to schizophrenia ...Schizophrenia is a life-long,complex mental illness that still lacks satisfactory treatments.In recent years,increasing numbers of candidate biomarkers of schizophrenia occurrences and drug responses to schizophrenia therapies have been successfully identified by many omics studies.This review discusses the latest discoveries regarding effective drug targets and relevant drug classifications in schizophrenia.It also assesses our understanding of biomarkers for drug efficacy and adverse drug reactions in current schizophrenia treatments using omics technologies.Future applications in clinical practice have been proposed based on these new findings,and are now considered highly promising strategies to better treat schizophrenia.Finally,we explore several novel approaches that aim to reveal additional genetic signatures of schizophrenia using multi-omics data,which are hoped to improve the diagnosis and treatment of this illness in the future.展开更多
文摘欧洲和北美是当前绅士化研究的主要阵地。从城市芝加哥学派到马克思主义范式,再到多元研究视角,绅士化理论的发展与欧美城市研究的发展趋势基本一致,这表明绅士化与更广泛的城市空间重构紧密联系。随着比较城市研究范式的兴起,绅士化在全球范围的普适性引发了诸多争议。本文以Web of Science数据库收集的1716篇文献为基础,通过可视化分析和文献综述,总结了近15年来国内外绅士化研究的演进、共识和争议。与欧美发达经济体相比,中国在政府与市场作用、国家主导地位、公众参与程度、产权制度等方面都呈现一种截然不同的绅士化过程,需正确认识我国经济转型过程中绅士化的形成机制,避免负面的社会空间效应,为我国新一轮城市化注入活力。
基金Supported by the 863 program(2012AA02A515,2012AA021802)the National Nature Science Foundation of China(81773818,81273596,30900799,81671326)+6 种基金National Key Research and Development Program(2017YFC0909303,2016YFC0905000,2016YFC0905002,2016YFC1200200,2016YFC0906400)the 4th Three-year Action Plan for Public Health of Shanghai(Project No.15GWZK0101)Shanghai Pujiang Program(17PJD020)Shanghai Key Laboratory of Psychotic Disorders(13dz2260500)Natural Science Foundation of Fujian Province(2016J05210)the Anhui Medical University for Scientific Research of BSKY(XJ201607)Anhui Medical University for Scientific Research(2017xkj006)
文摘OBJECTIVE:To explore biomarkers of Pien Tze Huang(片仔癀)that ameliorated the symptoms of hepatic fibrosis.METHODS:Two groups of carbon tetrachloride-induced hepatic fibrosis(HF)mice model were constructed in our study:one group received PZH treatment and another group received no treatment.We performed this study to investigate the role of PZH in the regulation process of hepatic fibrosis.RESULTS:We identified 31 down-regulated and 39 upregulated mi RNAs using small RNA-seq analysis.Combining RNA-Seq data analysis,our study revealed 7 significant target genes(Sp4,Slc2 a6,Tln2,Hmga2,Ank3,Pax9,Fgf9).The results of real-time quantitative polymerase chain reaction analysis suggested that the expression level of 6 genes(Sp4,Tln2,Hmga2,Ank3,Pax9,Fgf9)were down-regulated compared to control group.On the other hand,the expression level of Slc2 a6 appeared to be up-regulated.The protein mass spectrometry showed that PZH group had lower protein expression of Tln2 compared to control group.CONCLUSION:We identified 7 genes that were significantly related to PZH response in HF mice using multiple conjoint analysis methods.These genes could participate in underlying regulation mechanism of hepatic fibrosis during PZH treatment.
基金This work was supported by grants from the 863 Program(No.2012AA02A515,2012AA021802)the National Natural Science Foundation of China(No.81773818,81273596,30900799,81671326)+3 种基金the National Key Research and Development Program of China(No.2017YFC0909303,2016YFC0905000,2016YFC0905002,2016YFC1200200,2016YFC0906400)the 4th Three-year Action Plan for Public Health of Shanghai,China(No.15GWZK0101)Shanghai Pujiang Program,China(No.17PJD020)Shanghai Key Laboratory of Psychotic Disorders,China(No.13dz2260500).
文摘Schizophrenia is a life-long,complex mental illness that still lacks satisfactory treatments.In recent years,increasing numbers of candidate biomarkers of schizophrenia occurrences and drug responses to schizophrenia therapies have been successfully identified by many omics studies.This review discusses the latest discoveries regarding effective drug targets and relevant drug classifications in schizophrenia.It also assesses our understanding of biomarkers for drug efficacy and adverse drug reactions in current schizophrenia treatments using omics technologies.Future applications in clinical practice have been proposed based on these new findings,and are now considered highly promising strategies to better treat schizophrenia.Finally,we explore several novel approaches that aim to reveal additional genetic signatures of schizophrenia using multi-omics data,which are hoped to improve the diagnosis and treatment of this illness in the future.