目的:分析成人急性淋巴细胞白血病(ALL)患者的基因突变特征及其意义。方法:收集134例初治成人ALL患者的临床资料及16种基因突变的DNA测序结果,统计分析基因突变特征及其临床意义。结果:134例ALL患者中,31例(23.13%)检测到基因突变,其中...目的:分析成人急性淋巴细胞白血病(ALL)患者的基因突变特征及其意义。方法:收集134例初治成人ALL患者的临床资料及16种基因突变的DNA测序结果,统计分析基因突变特征及其临床意义。结果:134例ALL患者中,31例(23.13%)检测到基因突变,其中114例B-ALL患者中检测到19例(16.67%),19例T-ALL患者中检测到11例(57.89%)及1例T/B双表型ALL,T-ALL基因突变发生率显著高于B-ALL(χ^2=13.574,P<0.01)。共检测到12种基因突变,突变率从高到低依次为IL7R、NOTCH1、FLT3、TP53、FBXW7、PAX5、IKZF1、CREBBP、JAK3、JAK1、PHF6、PTEN。108例非移植可随访患者中,基因突变组(23例,21.30%)与无突变组(85例,78.70%)的1年总生存率(49.7%vs 67.4%)与中位无复发生存时间(214 d vs 260 d)差异均无统计学意义。NOTCH1基因突变组(4例,3.77%)与无突变组(102例,96.23%)的1年生存率差异有统计学意义(50.0%vs 65.8%,χ^2=9.840,P<0.01)。结论:成人ALL患者可能存在多种基因突变,其中IL7R、NOTCH1基因突变最常见,NOYCH1基因突变可能提示预后不良,基因突变检测有助于理解ALL发病机制及评估成人ALL患者的预后。展开更多
Objective： To observe the clinical efficacy and safety of cranial suture acupuncture plus paroxetine in treating depression, and to discuss the action mechanism of this acupuncture method. Methods： One hundred depre...Objective： To observe the clinical efficacy and safety of cranial suture acupuncture plus paroxetine in treating depression, and to discuss the action mechanism of this acupuncture method. Methods： One hundred depression patients were allocated to an observation group and a control group according to the random number table, with 50 cases in each group. The control group was intervened by oral administration of paroxetine tablets, 20 mg each time, once a day for successive 6 weeks; the observation group was additionally given cranial suture acupuncture, once a day for 6 weeks. They were scored by Hamilton depression scale-17 （HAMD-27） before the treatment and respectively after 1-week, 2-week, 4-week and 6-week treatment. The clinical efficacy and safety were also observed. Results： After 6-week treatment, the total effective rate was 94.0% in the observation group versus 78.0% in the control group, and the between-group difference was statistically significant （P〈0.01）. The HAMD-17 scores respectively after 1-week, 2-week, 4-week and 6-week treatment were significantly lower than the score before the treatment in the observation group （all P〈0.05）; the HAMD-17 scores respectively after 2-week, 4-week and 6-week treatment were significantly different from the score before the treatment in the control group （all P〈0.05）. There were significant differences in the HAMD-17 score between the two groups respectively after 4-week and 6-week treatment （both P〈0.05）. Conclusion： Cranial suture acupuncture plus paroxetine can ease the symptoms of depression, with faster onset and more significant therapeutic efficacy compared with paroxetine alone.展开更多
文摘目的:分析成人急性淋巴细胞白血病(ALL)患者的基因突变特征及其意义。方法:收集134例初治成人ALL患者的临床资料及16种基因突变的DNA测序结果,统计分析基因突变特征及其临床意义。结果:134例ALL患者中,31例(23.13%)检测到基因突变,其中114例B-ALL患者中检测到19例(16.67%),19例T-ALL患者中检测到11例(57.89%)及1例T/B双表型ALL,T-ALL基因突变发生率显著高于B-ALL(χ^2=13.574,P<0.01)。共检测到12种基因突变,突变率从高到低依次为IL7R、NOTCH1、FLT3、TP53、FBXW7、PAX5、IKZF1、CREBBP、JAK3、JAK1、PHF6、PTEN。108例非移植可随访患者中,基因突变组(23例,21.30%)与无突变组(85例,78.70%)的1年总生存率(49.7%vs 67.4%)与中位无复发生存时间(214 d vs 260 d)差异均无统计学意义。NOTCH1基因突变组(4例,3.77%)与无突变组(102例,96.23%)的1年生存率差异有统计学意义(50.0%vs 65.8%,χ^2=9.840,P<0.01)。结论:成人ALL患者可能存在多种基因突变,其中IL7R、NOTCH1基因突变最常见,NOYCH1基因突变可能提示预后不良,基因突变检测有助于理解ALL发病机制及评估成人ALL患者的预后。
文摘Objective： To observe the clinical efficacy and safety of cranial suture acupuncture plus paroxetine in treating depression, and to discuss the action mechanism of this acupuncture method. Methods： One hundred depression patients were allocated to an observation group and a control group according to the random number table, with 50 cases in each group. The control group was intervened by oral administration of paroxetine tablets, 20 mg each time, once a day for successive 6 weeks; the observation group was additionally given cranial suture acupuncture, once a day for 6 weeks. They were scored by Hamilton depression scale-17 （HAMD-27） before the treatment and respectively after 1-week, 2-week, 4-week and 6-week treatment. The clinical efficacy and safety were also observed. Results： After 6-week treatment, the total effective rate was 94.0% in the observation group versus 78.0% in the control group, and the between-group difference was statistically significant （P〈0.01）. The HAMD-17 scores respectively after 1-week, 2-week, 4-week and 6-week treatment were significantly lower than the score before the treatment in the observation group （all P〈0.05）; the HAMD-17 scores respectively after 2-week, 4-week and 6-week treatment were significantly different from the score before the treatment in the control group （all P〈0.05）. There were significant differences in the HAMD-17 score between the two groups respectively after 4-week and 6-week treatment （both P〈0.05）. Conclusion： Cranial suture acupuncture plus paroxetine can ease the symptoms of depression, with faster onset and more significant therapeutic efficacy compared with paroxetine alone.
