目的:分析成人急性淋巴细胞白血病(ALL)患者的基因突变特征及其意义。方法:收集134例初治成人ALL患者的临床资料及16种基因突变的DNA测序结果,统计分析基因突变特征及其临床意义。结果:134例ALL患者中,31例(23.13%)检测到基因突变,其中...目的:分析成人急性淋巴细胞白血病(ALL)患者的基因突变特征及其意义。方法:收集134例初治成人ALL患者的临床资料及16种基因突变的DNA测序结果,统计分析基因突变特征及其临床意义。结果:134例ALL患者中,31例(23.13%)检测到基因突变,其中114例B-ALL患者中检测到19例(16.67%),19例T-ALL患者中检测到11例(57.89%)及1例T/B双表型ALL,T-ALL基因突变发生率显著高于B-ALL(χ^2=13.574,P<0.01)。共检测到12种基因突变,突变率从高到低依次为IL7R、NOTCH1、FLT3、TP53、FBXW7、PAX5、IKZF1、CREBBP、JAK3、JAK1、PHF6、PTEN。108例非移植可随访患者中,基因突变组(23例,21.30%)与无突变组(85例,78.70%)的1年总生存率(49.7%vs 67.4%)与中位无复发生存时间(214 d vs 260 d)差异均无统计学意义。NOTCH1基因突变组(4例,3.77%)与无突变组(102例,96.23%)的1年生存率差异有统计学意义(50.0%vs 65.8%,χ^2=9.840,P<0.01)。结论:成人ALL患者可能存在多种基因突变,其中IL7R、NOTCH1基因突变最常见,NOYCH1基因突变可能提示预后不良,基因突变检测有助于理解ALL发病机制及评估成人ALL患者的预后。展开更多
Objective: To observe the clinical efficacy and safety of cranial suture acupuncture plus paroxetine in treating depression, and to discuss the action mechanism of this acupuncture method. Methods: One hundred depre...Objective: To observe the clinical efficacy and safety of cranial suture acupuncture plus paroxetine in treating depression, and to discuss the action mechanism of this acupuncture method. Methods: One hundred depression patients were allocated to an observation group and a control group according to the random number table, with 50 cases in each group. The control group was intervened by oral administration of paroxetine tablets, 20 mg each time, once a day for successive 6 weeks; the observation group was additionally given cranial suture acupuncture, once a day for 6 weeks. They were scored by Hamilton depression scale-17 (HAMD-27) before the treatment and respectively after 1-week, 2-week, 4-week and 6-week treatment. The clinical efficacy and safety were also observed. Results: After 6-week treatment, the total effective rate was 94.0% in the observation group versus 78.0% in the control group, and the between-group difference was statistically significant (P〈0.01). The HAMD-17 scores respectively after 1-week, 2-week, 4-week and 6-week treatment were significantly lower than the score before the treatment in the observation group (all P〈0.05); the HAMD-17 scores respectively after 2-week, 4-week and 6-week treatment were significantly different from the score before the treatment in the control group (all P〈0.05). There were significant differences in the HAMD-17 score between the two groups respectively after 4-week and 6-week treatment (both P〈0.05). Conclusion: Cranial suture acupuncture plus paroxetine can ease the symptoms of depression, with faster onset and more significant therapeutic efficacy compared with paroxetine alone.展开更多
文摘目的:分析成人急性淋巴细胞白血病(ALL)患者的基因突变特征及其意义。方法:收集134例初治成人ALL患者的临床资料及16种基因突变的DNA测序结果,统计分析基因突变特征及其临床意义。结果:134例ALL患者中,31例(23.13%)检测到基因突变,其中114例B-ALL患者中检测到19例(16.67%),19例T-ALL患者中检测到11例(57.89%)及1例T/B双表型ALL,T-ALL基因突变发生率显著高于B-ALL(χ^2=13.574,P<0.01)。共检测到12种基因突变,突变率从高到低依次为IL7R、NOTCH1、FLT3、TP53、FBXW7、PAX5、IKZF1、CREBBP、JAK3、JAK1、PHF6、PTEN。108例非移植可随访患者中,基因突变组(23例,21.30%)与无突变组(85例,78.70%)的1年总生存率(49.7%vs 67.4%)与中位无复发生存时间(214 d vs 260 d)差异均无统计学意义。NOTCH1基因突变组(4例,3.77%)与无突变组(102例,96.23%)的1年生存率差异有统计学意义(50.0%vs 65.8%,χ^2=9.840,P<0.01)。结论:成人ALL患者可能存在多种基因突变,其中IL7R、NOTCH1基因突变最常见,NOYCH1基因突变可能提示预后不良,基因突变检测有助于理解ALL发病机制及评估成人ALL患者的预后。
文摘Objective: To observe the clinical efficacy and safety of cranial suture acupuncture plus paroxetine in treating depression, and to discuss the action mechanism of this acupuncture method. Methods: One hundred depression patients were allocated to an observation group and a control group according to the random number table, with 50 cases in each group. The control group was intervened by oral administration of paroxetine tablets, 20 mg each time, once a day for successive 6 weeks; the observation group was additionally given cranial suture acupuncture, once a day for 6 weeks. They were scored by Hamilton depression scale-17 (HAMD-27) before the treatment and respectively after 1-week, 2-week, 4-week and 6-week treatment. The clinical efficacy and safety were also observed. Results: After 6-week treatment, the total effective rate was 94.0% in the observation group versus 78.0% in the control group, and the between-group difference was statistically significant (P〈0.01). The HAMD-17 scores respectively after 1-week, 2-week, 4-week and 6-week treatment were significantly lower than the score before the treatment in the observation group (all P〈0.05); the HAMD-17 scores respectively after 2-week, 4-week and 6-week treatment were significantly different from the score before the treatment in the control group (all P〈0.05). There were significant differences in the HAMD-17 score between the two groups respectively after 4-week and 6-week treatment (both P〈0.05). Conclusion: Cranial suture acupuncture plus paroxetine can ease the symptoms of depression, with faster onset and more significant therapeutic efficacy compared with paroxetine alone.