Glioblastoma is one of the most angiogenic human tumors and characterized by microvascular proliferations.A better understanding of glioblastoma vasculature is needed to optimize anti-angiogenic therapy that has shown...Glioblastoma is one of the most angiogenic human tumors and characterized by microvascular proliferations.A better understanding of glioblastoma vasculature is needed to optimize anti-angiogenic therapy that has shown a promising but incomplete efficacy.The present study examined 48 glioblastomas by CD34 endothelial marker periodic acid-Schiff(PAS)dual staining and found non-endothelial cell-lined展开更多
【据BMC Medicine 2021年7月报道】题:慢性HBV感染母亲所分娩婴儿增加乙型肝炎疫苗剂量的母婴阻断效果及免疫应答情况:一项前瞻性、多中心、大样本队列研究(作者Zhang XH等)母婴传播是我国HBV最主要的传播途径之一,接种乙型肝炎疫苗是阻...【据BMC Medicine 2021年7月报道】题:慢性HBV感染母亲所分娩婴儿增加乙型肝炎疫苗剂量的母婴阻断效果及免疫应答情况:一项前瞻性、多中心、大样本队列研究(作者Zhang XH等)母婴传播是我国HBV最主要的传播途径之一,接种乙型肝炎疫苗是阻断HBV母婴传播和预防婴儿感染HBV的主要策略,婴儿联合注射乙型肝炎免疫球蛋白可进一步提高免疫效果。然而,即使出生后及时完成了乙型肝炎疫苗联合免疫球蛋白的主被动联合免疫,仍有约5%婴儿发生阻断失败,还有部分婴儿会表现为无(低)应答。既往研究发现乙型肝炎疫苗的剂量是影响阻断效果的主要因素之一(10μg重组酵母乙型肝炎疫苗的阻断效果显著优于5μg重组酵母乙型肝炎疫苗)。基于此,来自首都医科大学附属北京佑安医院人工肝治疗中心的Zhang等进行了首个前瞻性、多中心、大样本的队列研究,探讨增加婴儿接种乙型肝炎疫苗的剂量,是否影响乙型肝炎母婴阻断效果、免疫应答水平及疫苗的安全性。展开更多
Background: To determine if sinusitis is associated with arterial hypertension in the Canadian population. Methods: Complex survey design incorporating stratification, multiple stages of selection, and unequal probabi...Background: To determine if sinusitis is associated with arterial hypertension in the Canadian population. Methods: Complex survey design incorporating stratification, multiple stages of selection, and unequal probabilities of selection of respondents. Cross-sectional data from 52,992 subjects(25,324 males and 27,668 females) 20- 64 years of age who participated in the second cycle of the National Population Health Survey(NPHS), conducted in 1996- 1997. All these individuals were asked if they had certain chronic health conditions, that had lasted or were expected to last 6 months or more, including sinusitis and high blood pressure. Results: Overall,males with sinusitis were just over 2% more likely to have hypertension(9.3% vs. 7.1% ) whereas the difference was 4% for women(11.8% vs. 7.6% ). Adjusted for age, region, habitation, immigrant status, household size, number of bedrooms, income adequacy, education level, smoking status, alcohol consumption, regular exercise and body mass index, the adjusted odds ratio for females was 1.42(95% CI 1.04, 1.95). Conclusions: Reported sinusitis is associated with hypertension but only in women. Mechanisms linking upper respiratory disorders to hypertension merit investigation.展开更多
文摘Glioblastoma is one of the most angiogenic human tumors and characterized by microvascular proliferations.A better understanding of glioblastoma vasculature is needed to optimize anti-angiogenic therapy that has shown a promising but incomplete efficacy.The present study examined 48 glioblastomas by CD34 endothelial marker periodic acid-Schiff(PAS)dual staining and found non-endothelial cell-lined
文摘【据《Hepatol Int》2020年1月报道】题:相对骨骼肌质量与非酒精性脂肪性肝病的关系:一项系统评价和荟萃分析(作者Cai C等)非酒精性脂肪性肝病(NAFLD)已逐渐成为全世界最常见的慢性肝病之一。越来越多的证据表明,低骨骼肌质量指数(SMI)可能在NAFLD的发展中起作用。该研究目的是探讨量化SMI、肌少症与NAFLD发生和发展之间的关联。作者系统地检索了PubMed、Embase、Web of Science和Cochrane图书馆中相关的英语研究,时间截止至2018年12月20日。
文摘【据BMC Medicine 2021年7月报道】题:慢性HBV感染母亲所分娩婴儿增加乙型肝炎疫苗剂量的母婴阻断效果及免疫应答情况:一项前瞻性、多中心、大样本队列研究(作者Zhang XH等)母婴传播是我国HBV最主要的传播途径之一,接种乙型肝炎疫苗是阻断HBV母婴传播和预防婴儿感染HBV的主要策略,婴儿联合注射乙型肝炎免疫球蛋白可进一步提高免疫效果。然而,即使出生后及时完成了乙型肝炎疫苗联合免疫球蛋白的主被动联合免疫,仍有约5%婴儿发生阻断失败,还有部分婴儿会表现为无(低)应答。既往研究发现乙型肝炎疫苗的剂量是影响阻断效果的主要因素之一(10μg重组酵母乙型肝炎疫苗的阻断效果显著优于5μg重组酵母乙型肝炎疫苗)。基于此,来自首都医科大学附属北京佑安医院人工肝治疗中心的Zhang等进行了首个前瞻性、多中心、大样本的队列研究,探讨增加婴儿接种乙型肝炎疫苗的剂量,是否影响乙型肝炎母婴阻断效果、免疫应答水平及疫苗的安全性。
文摘Background: To determine if sinusitis is associated with arterial hypertension in the Canadian population. Methods: Complex survey design incorporating stratification, multiple stages of selection, and unequal probabilities of selection of respondents. Cross-sectional data from 52,992 subjects(25,324 males and 27,668 females) 20- 64 years of age who participated in the second cycle of the National Population Health Survey(NPHS), conducted in 1996- 1997. All these individuals were asked if they had certain chronic health conditions, that had lasted or were expected to last 6 months or more, including sinusitis and high blood pressure. Results: Overall,males with sinusitis were just over 2% more likely to have hypertension(9.3% vs. 7.1% ) whereas the difference was 4% for women(11.8% vs. 7.6% ). Adjusted for age, region, habitation, immigrant status, household size, number of bedrooms, income adequacy, education level, smoking status, alcohol consumption, regular exercise and body mass index, the adjusted odds ratio for females was 1.42(95% CI 1.04, 1.95). Conclusions: Reported sinusitis is associated with hypertension but only in women. Mechanisms linking upper respiratory disorders to hypertension merit investigation.
