目的探究祛风宣窍、清肺化痰法治疗小儿过敏性鼻炎风痰蕴肺证的临床疗效。方法选取医院2017年1月—2019年2月115例小儿过敏性鼻炎患儿作为研究对象,按照随机数字表法分为观察组(58例)、对照组(57例)。对照组给予西医常规治疗,观察组在...目的探究祛风宣窍、清肺化痰法治疗小儿过敏性鼻炎风痰蕴肺证的临床疗效。方法选取医院2017年1月—2019年2月115例小儿过敏性鼻炎患儿作为研究对象,按照随机数字表法分为观察组(58例)、对照组(57例)。对照组给予西医常规治疗,观察组在对照组基础上给予祛风宣窍、清肺化痰法治疗。治疗1个月后,比较两组疗效、治疗前后中医证候积分、鼻腔灌洗液嗜酸性粒细胞(EOS)、嗜酸性粒细胞阳离子蛋白(ECP)、免疫抑制因子[白细胞介素-10(IL-10)、转化生长因子β(TGF-β)]水平及不良反应发生情况,并随访6个月,比较两组复发率。结果观察组治疗总有效率[94.83%(55/58) vs 78.95%(45/57)]高于对照组,随访6个月复发率[5.45%(3/55) vs 18.18%(10/55)]低于对照组(P<0.05);治疗1个月后,观察组鼻痒、鼻塞、流涕、喷嚏积分低于对照组(P<0.05);观察组鼻腔灌洗液EOS、ECP水平低于对照组,IL-10、TGF-β水平高于对照组(P<0.05);观察组不良反应发生率[12.07%(7/58) vs 8.77%(5/57)]与对照组相比,差异无统计学意义(P>0.05)。结论祛风宣窍、清肺化痰法治疗小儿过敏性鼻炎,可明显缓解患者临床症状,降低EOS、ECP水平,提高IL-10、TGF-β水平,减少复发,效果较为显著,且安全性高。展开更多
Mauremys mutica(Cantor,1842)is an endangered species in China.Main phenotypic variations inbody color,body weight,body shape,clutch size,egg size,and hatchling size were revealed betweenthe southern and northern popul...Mauremys mutica(Cantor,1842)is an endangered species in China.Main phenotypic variations inbody color,body weight,body shape,clutch size,egg size,and hatchling size were revealed betweenthe southern and northern populations.Both populations have the phenomenon of'larger male'sexualsize dimorphism(SSD),especially in the southern population.Furthermore,genetic variations betweenthe two populations were analyzed by RAPD band patterns of 30 random individuals in each population.The average genetic distance was 0.299±0.108 among the samples of two populations.The average ge-netic distance between southern and northern populations was 0.305±0.046.Cluster analysis indicatedthat all the individuals from the southern and northern populations were clustered among themselves toform two distinct clades.A total of 20 population-specific RAPD fragments were scored from 16 primers,and could be used as RAPD markers for distinguishing the southern and the northern population.Basedon the nucleotide sequences of two RAPD markers,two pairs of SCAR primers(SC1-S and SC2-S)weredesigned,which could be used as SCAR markers for the southern population.According to the significantphenotypic and genetic variations,we suggested that the northern population and southern populationmight be considered as two separate taxa,the'northern taxon'and the'southern taxon',and the con-servation should be respectively conducted on the two taxa.展开更多
由于缺少PlanetLab等公共地标平台,高精度IP定位技术仍然面临着巨大的挑战。为解决这一问题,提出一种基于大规模兴趣点(Point of Interest,POI)地标与路径相似度的IP定位算法,爬取和去噪数字地图上的POI数据并跟踪地标探测路径来收集地...由于缺少PlanetLab等公共地标平台,高精度IP定位技术仍然面临着巨大的挑战。为解决这一问题,提出一种基于大规模兴趣点(Point of Interest,POI)地标与路径相似度的IP定位算法,爬取和去噪数字地图上的POI数据并跟踪地标探测路径来收集地标信息。进一步设计了加权二维字符串子序列内核算法挖掘路由路径相似性特征,以及基于半径领域的离群点检测聚类算法来定位目标节点。该算法挖掘了北京市和上海市的2038个和1429个可用地标。实验表明,该算法显著提高了IP定位技术的稳定性与准确性,实现了5.7 km的平均定位误差。展开更多
文摘目的探究祛风宣窍、清肺化痰法治疗小儿过敏性鼻炎风痰蕴肺证的临床疗效。方法选取医院2017年1月—2019年2月115例小儿过敏性鼻炎患儿作为研究对象,按照随机数字表法分为观察组(58例)、对照组(57例)。对照组给予西医常规治疗,观察组在对照组基础上给予祛风宣窍、清肺化痰法治疗。治疗1个月后,比较两组疗效、治疗前后中医证候积分、鼻腔灌洗液嗜酸性粒细胞(EOS)、嗜酸性粒细胞阳离子蛋白(ECP)、免疫抑制因子[白细胞介素-10(IL-10)、转化生长因子β(TGF-β)]水平及不良反应发生情况,并随访6个月,比较两组复发率。结果观察组治疗总有效率[94.83%(55/58) vs 78.95%(45/57)]高于对照组,随访6个月复发率[5.45%(3/55) vs 18.18%(10/55)]低于对照组(P<0.05);治疗1个月后,观察组鼻痒、鼻塞、流涕、喷嚏积分低于对照组(P<0.05);观察组鼻腔灌洗液EOS、ECP水平低于对照组,IL-10、TGF-β水平高于对照组(P<0.05);观察组不良反应发生率[12.07%(7/58) vs 8.77%(5/57)]与对照组相比,差异无统计学意义(P>0.05)。结论祛风宣窍、清肺化痰法治疗小儿过敏性鼻炎,可明显缓解患者临床症状,降低EOS、ECP水平,提高IL-10、TGF-β水平,减少复发,效果较为显著,且安全性高。
基金the National Basic Research Program of China(No.2004CB117405)the Key Research Program of Ocean and Fishery Bureau of Guangdong province(No.2001A09)
文摘Mauremys mutica(Cantor,1842)is an endangered species in China.Main phenotypic variations inbody color,body weight,body shape,clutch size,egg size,and hatchling size were revealed betweenthe southern and northern populations.Both populations have the phenomenon of'larger male'sexualsize dimorphism(SSD),especially in the southern population.Furthermore,genetic variations betweenthe two populations were analyzed by RAPD band patterns of 30 random individuals in each population.The average genetic distance was 0.299±0.108 among the samples of two populations.The average ge-netic distance between southern and northern populations was 0.305±0.046.Cluster analysis indicatedthat all the individuals from the southern and northern populations were clustered among themselves toform two distinct clades.A total of 20 population-specific RAPD fragments were scored from 16 primers,and could be used as RAPD markers for distinguishing the southern and the northern population.Basedon the nucleotide sequences of two RAPD markers,two pairs of SCAR primers(SC1-S and SC2-S)weredesigned,which could be used as SCAR markers for the southern population.According to the significantphenotypic and genetic variations,we suggested that the northern population and southern populationmight be considered as two separate taxa,the'northern taxon'and the'southern taxon',and the con-servation should be respectively conducted on the two taxa.
文摘由于缺少PlanetLab等公共地标平台,高精度IP定位技术仍然面临着巨大的挑战。为解决这一问题,提出一种基于大规模兴趣点(Point of Interest,POI)地标与路径相似度的IP定位算法,爬取和去噪数字地图上的POI数据并跟踪地标探测路径来收集地标信息。进一步设计了加权二维字符串子序列内核算法挖掘路由路径相似性特征,以及基于半径领域的离群点检测聚类算法来定位目标节点。该算法挖掘了北京市和上海市的2038个和1429个可用地标。实验表明,该算法显著提高了IP定位技术的稳定性与准确性,实现了5.7 km的平均定位误差。
