Parkinson’s disease(PD)is characterized by motor symptoms and non-motor symptoms chiefly attributed to the loss of dopaminergic neurons in the substantia nigra pars compacta[1].Approximately 3 million PD patients suf...Parkinson’s disease(PD)is characterized by motor symptoms and non-motor symptoms chiefly attributed to the loss of dopaminergic neurons in the substantia nigra pars compacta[1].Approximately 3 million PD patients suffer from motor deficits including tremors,muscle rigidity,bradykinesia and psychological abnormality[2].The main pathological change of PD is the degeneration and death of dopaminergic neurons in the substantia nigra pars compacta,which leads to a significant decrease in dopamine content in the striatum.The pathogenesis of PD is fairly complex.Genetic factors,environmental factors,aging,oxidative stress,and inflammation may be related to the degeneration and death of PD dopaminergic neurons[3].展开更多
基金This study was financially supported by Henan Youth Science Foundation of Henan Province(No.232300421310)Postdoctoral Foundation of China(No.2022M711080)+4 种基金The National Natural Science Foundation of China(No.82274612)Program for Science&Technology Innovation Talents in Universities of Henan Province(No.23HASTIT044)Innovative Research Team(in Science and Technology)in University of Henan Province(21IRTSTHN026)Henan Province Traditional Chinese Medicine Scientific Research Special Project(No.2022ZYZD21)Joint Research Fund of Science and Technology R&D Plan of Henan Province(NO.222301420068).
文摘Parkinson’s disease(PD)is characterized by motor symptoms and non-motor symptoms chiefly attributed to the loss of dopaminergic neurons in the substantia nigra pars compacta[1].Approximately 3 million PD patients suffer from motor deficits including tremors,muscle rigidity,bradykinesia and psychological abnormality[2].The main pathological change of PD is the degeneration and death of dopaminergic neurons in the substantia nigra pars compacta,which leads to a significant decrease in dopamine content in the striatum.The pathogenesis of PD is fairly complex.Genetic factors,environmental factors,aging,oxidative stress,and inflammation may be related to the degeneration and death of PD dopaminergic neurons[3].
